A systematic screen reveals new elements acting at the G2/M cell cycle control

Genome Biology

Volumn 13, Issue 5, 2012, Pages

  Navarro, Francisco J ^a   Nurse, Paul ^a,b,c  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b ROCKEFELLER UNIVERSITY   (United States)

^c THE FRANCIS CRICK INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; CELL CYCLE PROTEIN; CYCLINE; TYROSINE;

ARTICLE; CELL CYCLE REGULATION; CELL SIZE; CELLULAR STRESS RESPONSE; CLP1 GENE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; GENE; GENE CONTROL; GENE DELETION; GENE EXPRESSION PROFILING; GENE FUNCTION; GENETIC PROCEDURES; GENETIC SCREENING; GIT3 GENE; GIT5 GENE; GPA2 GENE; M PHASE CELL CYCLE CHECKPOINT; MITOSIS RATE; MOLECULAR DYNAMICS; NIF1 GENE; NONHUMAN; PAB2 GENE; PHASE TRANSITION; PKA1 GENE; POM1 GENE; PPA2 GENE; PYP1 GENE; SCHIZOSACCHAROMYCES POMBE; SGF73 GENE; SIGNAL TRANSDUCTION; SKI3 GENE; SNF5 GENE; SOL1 GENE; WEE1 GENE; WESTERN BLOTTING; WT GENE; ZFS1 GENE; FUNGAL GENOME; GENETICS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SCHIZOSACCHAROMYCES;

EUKARYOTA; SCHIZOSACCHAROMYCES POMBE; SCHIZOSACCHAROMYCETACEAE;

CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASES; CYCLINS; G2 PHASE CELL CYCLE CHECKPOINTS; GENOME, FUNGAL; PHOSPHORYLATION; SCHIZOSACCHAROMYCES; TYROSINE;

EID: 84861335714     PISSN: None     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/gb-2012-13-5-r36     Document Type: Article

References (46)

1. Mitchison JM, Novak B, Sveiczer A. Size control in the cell cycle. Cell Biol Int 1997, 21:461-463. 10.1006/cbir.1997.0187, 9451802.
2. Jorgensen P, Tyers M. How cells coordinate growth and division. Curr Biol 2004, 14:1014-1027.
3. Nurse P. Genetic control of cell size at cell division in yeast. Nature 1975, 256:547-551. 10.1038/256547a0, 1165770.
4. Carter BLA, Sudbery PE. Small-size mutants of Saccharomyces cerevisiae. Genetics 1980, 96:561-566. 1214361, 7021310.
5. Russell P, Nurse P. Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog. Cell 1987, 49:559-567. 10.1016/0092-8674(87)90458-2, 3032459.
6. Parker LL, Atherton-Fessler S, Piwnica-Worms H. p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15. Proc Natl Acad Sci USA 1992, 89:2917-2921. 10.1073/pnas.89.7.2917, 48774, 1372994.
7. Russell P, Nurse P. cdc25+ functions as an inducer in the mitotic control of fission yeast. Cell 1986, 45:145-153. 10.1016/0092-8674(86)90546-5, 3955656.
8. Gould KL, Nurse P. Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis. Nature 1989, 342:39-45. 10.1038/342039a0, 2682257.
9. Moreno S, Hayles J, Nurse P. Regulation of p34cdc2 protein kinase during mitosis. Cell 1989, 58:361-372. 10.1016/0092-8674(89)90850-7, 2665944.
10. Millar JB, Buck V, Wilkinson MG. Pyp1 and Pyp2 PTPases dephosphorylate an osmosensing MAP kinase controlling cell size at division in fission yeast. Genes Dev 1995, 9:2117-2130. 10.1101/gad.9.17.2117, 7657164.
11. Shiozaki K, Shiozaki M, Russell P. Heat stress activates fission yeast Spc1/StyI MAPK by a MEKK-independent mechanism. Mol Biol Cell 1998, 9:1339-1349. 25354, 9614178.
12. Russell P, Nurse P. The mitotic inducer nim1+ functions in a regulatory network of protein kinase homologs controlling the initiation of mitosis. Cell 1987, 49:569-576. 10.1016/0092-8674(87)90459-4, 3453113.
13. Martin SG, Berthelot-Grosjean M. Polar gradients of the DYRK-family kinase Pom1 couple cell length with the cell cycle. Nature 2009, 459:852-856. 10.1038/nature08054, 19474792.
14. Moseley JB, Mayeux A, Paoletti A, Nurse P. A spatial gradient coordinates cell size and mitotic entry in fission yeast. Nature 2009, 459:857-860. 10.1038/nature08074, 19474789.
15. Petersen J, Nurse P. TOR signalling regulates mitotic commitment through the stress MAP kinase pathway and the Polo and Cdc2 kinases. Nat Cell Biol 2007, 9:1263-1272. 10.1038/ncb1646, 17952063.
16. Petersen J, Hagan IM. Polo kinase links the stress pathway to cell cycle control and tip growth in fission yeast. Nature 2005, 435:507-512. 10.1038/nature03590, 15917811.
17. Hachet O, Berthelot-Grosjean M, Kokkoris K, Vincenzetti V, Moosbrugger J, Martin Sophie G. A phosphorylation cycle shapes gradients of the DYRK family kinase Pom1 at the plasma membrane. Cell 2011, 145:1116-1128. 10.1016/j.cell.2011.05.014, 21703453.
18. Coudreuse D, Nurse P. Driving the cell cycle with a minimal CDK control network. Nature 2010, 468:1074-1079. 10.1038/nature09543, 21179163.
19. Kim D-U, Hayles J, Kim D, Wood V, Park H-O, Won M, Yoo H-S, Duhig T, Nam M, Palmer G, Han S, Jeffery L, Baek S-T, Lee H, Shim YS, Lee M, Kim L, Heo K-S, Noh EJ, Lee A-R, Jang Y-J, Chung K-S, Choi S-J, Park J-Y, Park Y, Kim HM, Park S-K, Park H-J, Kang E-J, Kim HB, Kang H-S, et al. Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe. Nat Biotechnol 2010, 28:617-623. 10.1038/nbt.1628, 20473289.
20. Fantes P, Nurse P. Control of cell size at division in fission yeast by a growth-modulated size control over nuclear division. Exp Cell Res 1977, 107:377-386. 10.1016/0014-4827(77)90359-7, 872891.
21. Fantes PA, Nurse P. Control of the timing of cell division in fission yeast: cell size mutants reveal a second control pathway. Exp Cell Res 1978, 115:317-329. 10.1016/0014-4827(78)90286-0, 689088.
22. Jorgensen P, Nishikawa JL, Breitkreutz BJ, Tyers M. Systematic identification of pathways that couple cell growth and division in yeast. Science 2002, 297:395-400. 10.1126/science.1070850, 12089449.
23. Zhang J, Schneider C, Ottmers L, Rodriguez R, Day A, Markwardt J, Schneider BL. Genomic scale mutant hunt identifies cell size homeostasis genes in S. cerevisiae. Curr Biol 2002, 12:1992-2001. 10.1016/S0960-9822(02)01305-2, 12477387.
24. Tallada VA, Daga RR, Palomeque C, Garzún A, Jimenez J. Genome-wide search of Schizosaccharomyces pombe genes causing overexpression-mediated cell cycle defects. Yeast 2002, 19:1139-1151. 10.1002/yea.902, 12237855.
25. Kinoshita N, Yamano H, Niwa H, Yoshida T, Yanagida M. Negative regulation of mitosis by the fission yeast protein phosphatase ppa2. Genes Dev 1993, 7:1059-1071. 10.1101/gad.7.6.1059, 8389306.
26. Ottilie S, Chernoff J, Hannig G, Hoffman CS, Erikson RL. The fission yeast genes pyp1+ and pyp2+ encode protein tyrosine phosphatases that negatively regulate mitosis. Mol Cell Biol 1992, 12:5571-5580. 360496, 1448087.
27. Trautmann S, Wolfe BA, Jorgensen P, Tyers M, Gould KL, McCollum D. Fission yeast Clp1p phosphatase regulates G2/M transition and coordination of cytokinesis with cell cycle progression. Curr Biol 2001, 11:931-940. 10.1016/S0960-9822(01)00268-8, 11448769.
28. Wu L, Russell P. Nif1, a novel mitotic inhibitor in Schizosaccharomyces pombe. EMBO J 1997, 16:1342-1350. 10.1093/emboj/16.6.1342, 1169731, 9135149.
29. Stettler S, Warbrick E, Prochnik S, Mackie S, Fantes P. The wis1 signal transduction pathway is required for expression of cAMP-repressed genes in fission yeast. J Cell Sci 1996, 109:1927-1935.
30. Kishimoto N, Yamashita I. Cyclic AMP regulates cell size of Schizosaccharomyces pombe through Cdc25 mitotic inducer. Yeast 2000, 16:523-529. 10.1002/(SICI)1097-0061(200004)16:6<523::AID-YEA546>3.0.CO;2-5, 10790689.
31. Zuin A, Carmona M, Morales-Ivorra I, Gabrielli N, Vivancos AP, Ayte J, Hidalgo E. Lifespan extension by calorie restriction relies on the Sty1 MAP kinase stress pathway. EMBO J 2010, 29:981-991. 10.1038/emboj.2009.407, 2837171, 20075862.
32. Monahan BJ, Villen J, Marguerat S, Bahler J, Gygi SP, Winston F. Fission yeast SWI/SNF and RSC complexes show compositional and functional differences from budding yeast. Nat Struct Mol Biol 2008, 15:873-880. 10.1038/nsmb.1452, 2559950, 18622392.
33. Esteban V, Blanco M, Cueille N, Simanis V, Moreno S, Bueno A. A role for the Cdc14-family phosphatase Flp1p at the end of the cell cycle in controlling the rapid degradation of the mitotic inducer Cdc25p in fission yeast. J Cell Sci 2004, 117:2461-2468. 10.1242/jcs.01107, 15128870.
34. Wolfe BA, Gould KL. Fission yeast Clp1p phosphatase affects G2/M transition and mitotic exit through Cdc25p inactivation. EMBO J 2004, 23:919-929. 10.1038/sj.emboj.7600103, 381010, 14765109.
35. Hayles J, Fisher D, Woollard A, Nurse P. Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex. Cell 1994, 78:813-822. 10.1016/S0092-8674(94)90542-8, 8087848.
36. Moreno S, Nurse P. Regulation of progression through the G1 phase of the cell cycle by the rum1+ gene. Nature 1994, 367:236-242. 10.1038/367236a0, 8121488.
37. Correa-Bordes J, Nurse P. p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase. Cell 1995, 83:1001-1009. 10.1016/0092-8674(95)90215-5, 8521500.
38. Den Haese GJ, Walworth N, Carr AM, Gould KL. The Wee1 protein kinase regulates T14 phosphorylation of fission yeast Cdc2. Mol Biol Cell 1995, 6:371-385. 301198, 7626804.
39. Mochida S, Ikeo S, Gannon J, Hunt T. Regulated activity of PP2A-B55δ is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts. EMBO J 2009, 28:2777-2785. 10.1038/emboj.2009.238, 2750019, 19696736.
40. Visintin R, Craig K, Hwang ES, Prinz S, Tyers M, Amon A. The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation. Mol Cell 1998, 2:709-718. 10.1016/S1097-2765(00)80286-5, 9885559.
41. Moreno S, Klar A, Nurse P. Molecular genetic analysis of fission yeast Schizosaccharomyces pombe. Methods Enzymol 1991, 194:795-823.
42. PomBase. , http://www.pombase.org
43. Bähler J, Wu J-Q, Longtine MS, Shah NG, III AM, Steever AB, Wach A, Philippsen P, Pringle JR. Heterologous modules for efficient and versatile PCR-based gene targeting in Schizosaccharomyces pombe. Yeast 1998, 14:943-951. 10.1002/(SICI)1097-0061(199807)14:10<943::AID-YEA292>3.0.CO;2-Y, 9717240.
44. Bähler Lab Resources. , http://www.bahlerlab.info/resources/
45. Forsburg SL. Comparison of Schizosaccharomyces pombe expression systems. Nucleic Acids Res 1993, 21:2955-2956. 10.1093/nar/21.12.2955, 309706, 8332516.
46. Woods A, Sherwin T, Sasse R, MacRae TH, Baines AJ, Gull K. Definition of individual components within the cytoskeleton of Trypanosoma brucei by a library of monoclonal antibodies. J Cell Sci 1989, 93:491-500.