Psychopharmacology of schizophrenia: The future looks bleak

Mens Sana Monographs

Volumn 10, Issue 1, 2012, Pages 4-12

  Andrade, Chittaranjan ^a   Radhakrishnan, Rajiv ^b   Fernandes, Praveen P ^c  

^a NATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES   (India)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Pharmacotherapy; Primary prevention; Schizophrenia; Secondary prevention; Tertiary prevention

Indexed keywords

EID: 84861325843     PISSN: 09731229     EISSN: 19984014     Source Type: Journal    
DOI: 10.4103/0973-1229.91293     Document Type: Review

References (39)

1. AbdelMalik P, Husted J, Chow EW, Bassett AS. Childhood head injury and expression of schizophrenia in multiply affected families. Arch Gen Psychiatry 2003;60:231-6. PMID: 12622655. (Pubitemid 36307433)
2. Andrade C. Psychopharmacology. In: Bhugra D, Ranjith G, Chaturvedi SK, editors. Handbook of Psychiatry: A South Asian Perspective. 2nd ed. New Delhi: Byword Viva; 2012.
3. Andreasen NC, Pierson R. The role of the cerebellum in schizophrenia. Biol Psychiatry 2008;64:81-8. PMID: 18395701.
4. Arnsten AF. Prefrontal cortical network connections: Key site of vulnerability in stress and schizophrenia. Int J Dev Neurosci 2011;29:215-23. PMID: 21345366.
5. Cannon M, Jones PB, Murray RM. Obstetric complications and schizophrenia: Historical and meta-analytic review. Am J Psychiatry 2002;159:1080-92. PMID: 12091183. (Pubitemid 34743246)
6. Caplan G. Principles of preventive psychiatry. New York: Basic Books; 1964.
7. Corcoran C, Walker E, Huot R, Mittal V, Tessner K, Kestler L, et al. The stress cascade and schizophrenia: Etiology and onset. Schizophr Bull 2003;29:671-92. PMID: 14989406. (Pubitemid 38181949)
8. Dalman C, Allebeck P, Cullberg J, Grunewald C, Köster M. Obstetric complications and the risk of schizophrenia: A longitudinal study of a national birth cohort. Arch Gen Psychiatry 1999;56:234-40. PMID: 10078500. (Pubitemid 29125131)
9. Davies G, Welham J, Chant D, Torrey EF, McGrath J. A systematic review and meta-analysis of Northern Hemisphere season of birth studies in schizophrenia. Schizophr Bull 2003;29:587-93. PMID: 14609251. (Pubitemid 37339392)
10. Do KQ, Cabungcal JH, Frank A, Steullet P, Cuenod M. Redox dysregulation, neurodevelopment, and schizophrenia. Curr Opin Neurobiol 2009;19:220-30. PMID: 19481443.
11. Girard SL, Xiong L, Dion PA, Rouleau GA. Where are the missing pieces of the schizophrenia genetics puzzle? Curr Opin Genet Dev 2011;21:310-6. PMID: 21277191.
12. Kane JM, Correll CU. Past and present progress in the pharmacologic treatment of schizophrenia. J Clin Psychiatry 2010;71:1115-24. PMID: 20923620.
13. Keshavan MS, Tandon R, Boutros NN, Nasrallah HA. Schizophrenia, "just the facts": What we know in 2008 Part 3: neurobiology. Schizophr Res 2008;106:89-107. PMID: 18799287.
14. Kuhn TS. The Structure of Scientific Revolutions (p52-65). 1st ed. Chicago: University of Chicago Press; 1962.
15. Levitt JJ, Bobrow L, Lucia D, Srinivasan P. A selective review of volumetric and morphometric imaging in schizophrenia. Curr Top Behav Neurosci 2010;4:243-81. PMID: 21312403.
16. Marshall M, Lewis S, Lockwood A, Drake R, Jones P, Croudace T. Association between duration of untreated psychosis and outcome in cohorts of first-episode patients: A systematic review. Arch Gen Psychiatry 2005;62:975-83. PMID: 16143729. (Pubitemid 41248376)
17. Marshall M, Lockwood A. Early Intervention for psychosis. Cochrane Database Syst Rev 2004;(2):CD004718. PMID: 15106257.
18. Mattai A, Hosanagar A, Weisinger B, Greenstein D, Stidd R, Clasen L, et al. Hippocampal volume development in healthy siblings of childhood-onset schizophrenia patients. Am J Psychiatry 2011;168:427-35. PMID: 21245087.
19. Maynard TM, Sikich L, Lieberman JA, LaMantia AS. Neural development, cell-cell signaling, and the "two-hit" hypothesis of schizophrenia. Schizophr Bull 2001;27:457-76. PMID: 11596847. (Pubitemid 33081697)
20. McGorry PD. Is early intervention in the major psychiatric disorders justified? Yes. BMJ 2008;337:a695. PMID: 18678593.
21. Melle I, Larsen TK, Haahr U, Friis S, Johannesen JO, Opjordsmoen S, et al. Prevention of negative symptom psychopathologies in first-episode schizophrenia: Two-year effects of reducing the duration of untreated psychosis. Arch Gen Psychiatry 2008;65:634-40. PMID: 18519821. (Pubitemid 351787234)
22. Mittal VA, Ellman LM, Cannon TD. Gene-environment interaction and covariation in schizophrenia: The role of obstetric complications. Schizophr Bull 2008;34:1083-94. PMID: 18635675.
23. Pelosi A. Is early intervention in the major psychiatric disorders justified? No. BMJ 2008;337:a710. PMID: 18678594.
24. Penner JD, Brown AS. Prenatal infectious and nutritional factors and risk of adult schizophrenia. Expert Rev Neurother 2007;7:797-805. PMID: 17610387. (Pubitemid 47037720)
25. Perkins DO, Gu H, Boteva K, Lieberman JA. Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia: A critical review and meta-analysis. Am J Psychiatry 2005;162:1785-804. PMID: 16199825. (Pubitemid 41428609)
26. Prasad KM, Talkowski ME, Chowdari KV, McClain L, Yolken RH, Nimgaonkar VL. Candidate genes and their interactions with other genetic/environmental risk factors in the etiology of schizophrenia. Brain Res Bull 2010;83:86-92. PMID: 19729054.
27. Rabinowitz J, Levine SZ, Haim R, Häfner H. The course of schizophrenia: Progressive deterioration, amelioration or both? Schizophr Res 2007;91:254-8. PMID: 17293084.
28. Saha S, Welham J, Chant D, McGrath J. Incidence of schizophrenia does not vary with economic status of the country: Evidence from a systematic review. Soc Psychiatry Psychiatr Epidemiol 2006;41:338-40. PMID: 16520883. (Pubitemid 43676247)
29. Schnieder TP, Dwork AJ. Searching for neuropathology: Gliosis in schizophrenia. Biol Psychiatry 2011;69:134-9. PMID: 21035789.
30. St Clair D, Xu M, Wang P, Yu Y, Fang Y, Zhang F, et al. Rates of adult schizophrenia following prenatal exposure to the chinese famine of 1959-1961. JAMA 2005;294:557-62. PMID: 16077049. (Pubitemid 41126897)
31. Stahl SM. Stahl's Essential Psychopharmacology: Neuroscientific Basis and Practical Applications. 3rd ed. Cambridge: Cambridge University Press; 2008.
32. Tamminga CA, Stan AD, Wagner AD. The hippocampal formation in schizophrenia. Am J Psychiatry 2010;167:1178-93. PMID: 20810471.
33. Tandon R, Keshavan MS, Nasrallah HA. Schizophrenia, "just the facts" what we know in 2008. 2. Epidemiology and etiology. Schizophr Res 2008;102:1-18. PMID: 18514488.
34. Tandon R, Nasrallah HA, Keshavan MS. Schizophrenia, "just the facts" 4. Clinical features and conceptualization. Schizophr Res 2009;110:1-23. PMID: 19328655.
35. Tsuang M. Schizophrenia: Genes and environment. Biol Psychiatry 2000;47:210-20. PMID: 10682218. (Pubitemid 30077397)
36. van Os J, Kapur S. Schizophrenia. Lancet 2009;374:635-45. PMID: 19700006.
37. van Rijn S, Aleman A, de Sonneville L, Sprong M, Ziermans T, Schothorst P, et al. Neuroendocrine markers of high risk for psychosis: Salivary testosterone in adolescent boys with prodromal symptoms. Psychol Med 2011;41:1815-22. PMID: 21251344.
38. Verdoux H. Perinatal risk factors for schizophrenia: How specific are they? Curr Psychiatry Rep 2004;6:162-7. PMID: 1542468. (Pubitemid 38906841)
39. Whitford TJ, Kubicki M, Schneiderman JS, O'Donnell LJ, King R, Alvarado JL, et al. Corpus callosum abnormalities and their association with psychotic symptoms in patients with schizophrenia. Biol Psychiatry 2010;68:70-7. PMID: 20494336.