Carboxyl-terminal amino acids 1052 to 1082 of the latency-associated nuclear antigen (LANA) interact with RBP-JΚ and are responsible for LANA-Mediated RTA repression

Journal of Virology

Volumn 86, Issue 9, 2012, Pages 4956-4969

  Jin, Yi ^a   He, Zhiheng ^a   Liang, Deguang ^a   Zhang, Quanzhi ^a   Zhang, Hongxing ^a   Deng, Qiang ^a   Robertson, Erle S ^b   Lan, Ke ^a  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE BINDING PROTEIN; LATENCY ASSOCIATED NUCLEAR ANTIGEN;

ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL STRAIN HEK293; COMPLEX FORMATION; CONSENSUS SEQUENCE; CONTROLLED STUDY; EPISOME; GENE REPRESSION; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; REPLICATION AND TRANSCRIPTION ACTIVATOR GENE; VIRION; VIRUS GENE; VIRUS GENOME; VIRUS LATENCY; VIRUS REACTIVATION; VIRUS REPLICATION;

AMINO ACID SEQUENCE; AMINO ACIDS; ANTIGENS, VIRAL; CELL LINE; CONSENSUS SEQUENCE; GENES, VIRAL; GENOME, VIRAL; HUMANS; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE-BINDING PROTEIN; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; SEQUENCE DELETION; VIRUS REPLICATION;

HERPESVIRIDAE; HUMAN HERPESVIRUS 8;

EID: 84861322316     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.06788-11     Document Type: Article

References (48)

1. An F-Q, et al. 2005. The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus modulates cellular gene expression and protects lymphoid cells from p16 INK4A-induced cell cycle arrest. J. Biol. Chem. 280:3862-3874.
2. Bubman D, Guasparri I, Cesarman E. 2007. Deregulation of c-Myc in primary effusion lymphoma by Kaposi's sarcoma herpesvirus latencyassociated nuclear antigen. Oncogene 26:4979-4986.
3. Cai Q-L, Knight JS, Verma SC, Zald P, Robertson ES. 2006. EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the p53 tumor suppressors. PLoS Pathog. 2:e116.
4. Cesarman E, Chang Y, Moore PS, Said JW, Knowles DM. 1995. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N. Engl. J. Med. 332:1186-1191.
5. Chang P-J, Boonsiri J, Wang S-S, Chen L-Y, Miller G. 2010. Binding of RBP-JΚ (CSL) protein to the promoter of the Kaposi's sarcoma-associated herpesvirus ORF47 (gL) gene is a critical but not sufficient determinant of transactivation by ORF50 protein. Virology 398:38-48.
6. Chang Y, et al. 1994. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 266:1865-1869.
7. Chou PY, FGD. 1978. Prediction of the secondary structure of proteins from their amino acid sequence. Adv. Enzymol. 47:45-148.
8. Curreli F, Friedman-Kien AE, Flore O. 2005. Glycyrrhizic acid alters Kaposi sarcoma-associated herpesvirus latency, triggering p53-mediated apoptosis in transformed B lymphocytes. J. Clin. Invest. 115:642-652.
9. Friedmann DR, Wilson JJ, Kovall RA. 2008. RAM-induced allostery facilitates assembly of a Notch pathway active transcription complex. J. Biol. Chem. 283:14781-14791.
10. Fujimuro M, et al. 2003. A novel viral mechanism for dysregulation of β-catenin in Kaposi's sarcoma-associated herpesvirus latency. Nat. Med. 9:300-306.
11. Garber AC, Shu MA, Hu J, Renne R. 2001. DNA binding and modulation of gene expression by the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus. J. Virol. 75:7882-7892.
12. Grossman SR, Johannsen E, Tong X, Yalamanchili R, Kieff E. 1994. The Epstein-Barr virus nuclear antigen 2 transactivator is directed to response elements by the J. kappa recombination signal binding protein. Proc. Natl. Acad. Sci. U. S. A. 91:7568-7572.
13. Grundhoff A, Ganem D. 2003. The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus permits replication of terminal repeat-containing plasmids. J. Virol. 77:2779-2783.
14. He Z, et al. 2010. Cellular corepressor TLE2 inhibits replication-andtranscription-activator-mediated transactivation and lytic reactivation of Kaposi's sarcoma-associated herpesvirus. J. Virol. 84:2047-2062.
15. Henkel T, Ling P, Hayward S, Peterson M. 1994. Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein JΚ. Science 265:92-95.
16. Hsieh JJ, Zhou S, Chen L, Young DB, Hayward SD. 1999. CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. Proc. Natl. Acad. Sci. U. S. A. 96:23-28.
17. Kedes DH, Lagunoff M, Renne R, Ganem D. 1997. Identification of the gene encoding the major latency-associated nuclear antigen of the Kaposi's sarcoma-associated herpesvirus. J. Clin. Invest. 100:2606-2610.
18. Klass CM, Offermann MK. 2005. Targeting human herpesvirus-8 for treatment of Kaposi's sarcoma and primary effusion lymphoma. Curr. Opin. Oncol. 17:447-455.
19. Knight JS, Cotter MA II, Robertson ES. 2001. The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus transactivates the telomerase reverse transcriptase promoter. J. Biol. Chem. 276:22971-22978.
20. Kovall RA, Hendrickson WA. 2004. Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA. EMBO J. 23:3441-3451.
21. Lan K, Kuppers DA, Robertson ES. 2005. Kaposi's sarcoma-associated herpesvirus reactivation is regulated by interaction of latency-associated nuclear antigen with recombination signal sequence-binding protein JΚ, the major downstream effector of the Notch signaling pathway. J. Virol. 79:3468-3478.
22. Lan K, Kuppers DA, Verma SC, Robertson ES. 2004. Kaposi's sarcomaassociated herpesvirus-encoded latency-associated nuclear antigen inhibits lytic replication by targeting Rta: a potential mechanism for virusmediated control of latency. J. Virol. 78:6585-6594.
23. Li Q, Zhou F, Ye F, Gao S-J. 2008. Genetic disruption of KSHV major latent nuclear antigen LANA enhances viral lytic transcriptional program. Virology 379:234-244.
24. Liang YY, Chang J, Lynch SJ, Lukac DM, Ganem D. 2002. The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-JΚ (CSL), the target of the Notch signaling pathway. Genes Dev. 16:1977-1989.
25. Liang YY, Ganem D. 2003. Lytic but not latent infection by Kaposi's sarcoma-associated herpesvirus requires host CSL protein, the mediator of Notch signaling. Proc. Natl. Acad. Sci. U. S. A. 100:8490-8495.
26. Lim C, Gwack Y, Hwang S, Kim S, Choe J. 2001. The transcriptional activity of cAMP response element-binding protein-binding protein is modulated by the latency associated nuclear antigen of Kaposi's sarcomaassociated herpesvirus. J. Biol. Chem. 276:31016-31022.
27. Liu YH, et al. 2008. Kaposi's sarcoma-associated herpesvirus RTA activates the processivity factor ORF59 through interaction with RBP-JΚ and a cis-acting RTA responsive element. Virology 380:264-275.
28. Lu J, Verma SC, Cai Q, Robertson ES. 2011. The Single RBP-JΚ site within the LANA promoter is crucial for establishing Kaposi's sarcomaassociated herpesvirus latency during primary infection. J. Virol. 85: 6148-6161.
29. Lu J, et al. 2009. Latency-associated nuclear antigen of Kaposi's sarcomaassociated herpesvirus (KSHV) upregulates survivin expression in KSHVassociated B-lymphoma cells and contributes to their proliferation. J. Virol. 83:7129-7141.
30. Nakamura H, et al. 2003. Global changes in Kaposi's sarcoma-associated virus gene expression patterns following expression of a tetracyclineinducible Rta transactivator. J. Virol. 77:4205-4220.
31. Nam Y, Sliz P, Song L, Aster JC, Blacklow SC. 2006. Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell 124:973-983.
32. Niwa H, Yamamura K, Miyazaki J. 1991. Efficient selection for highexpression transfectants with a novel eukaryotic vector. Gene 108:193-200.
33. Oswald F, et al. 2005. RBP-JΚ/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes. Mol. Cell. Biol. 25:10379-10390.
34. Paulose-Murphy M, et al. 2001. Transcription program of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus). J. Virol. 75:4843-4853.
35. Pearson WR. 1990. Rapid and sensitive sequence comparison with FASTP and FASTA. Methods Enzymol. 183:63-98.
36. Persson LM, Wilson AC. 2010 Feb. Wide-scale use of Notch signaling factor CSL/RBP-JΚ in RTA-mediated activation of Kaposi's sarcomaassociated herpesvirus lytic genes. J. Virol. 84:1334-1347.
37. Rainbow L, et al. 1997. The 222- to 234-kilodalton latent nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear antigen. J. Virol. 71:5915-5921.
38. Russo JJ, et al. 1996. Nucleotide sequence of the Kaposi sarcomaassociated herpesvirus (HHV8). Proc. Natl. Acad. Sci. U. S. A. 93:14862-14867.
39. Said W, et al. 1996. Kaposi's sarcoma-associated herpesvirus (KSHV or HHV8) in primary effusion lymphoma: ultrastructural demonstration of herpesvirus in lymphoma cells. Blood 87:4937-4943.
40. Sarid R, Flore O, Bohenzky RA, Chang Y, Moore PS. 1998. Transcription mapping of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) genome in a body cavity-based lymphoma cell line (BC-1). J. Virol. 72:1005-1012.
41. Sarid R, Klepfish A, Schattner A. 2002. Virology, pathogenetic mechanisms, and associated diseases of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8). Mayo Clin. Proc. 77:941-949.
42. Schwam DR, Luciano RL, Mahajan SS, Wong L, Wilson AC. 2000. Carboxy terminus of human herpesvirus 8 latency-associated nuclear antigen mediates dimerization, transcriptional repression, and targeting to nuclear bodies. J. Virol. 74:8532-8540.
43. Shinohara H, et al. 2002. Chromosome binding site of latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus is essential for persistent episome maintenance and is functionally replaced by histone H1. J. Virol. 76:12917-12924.
44. Soulier J, et al. 1995. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood 86:1276-1280.
45. Tamura K, et al. 1995. Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-JΚ/Su(H). Curr. Biol. 5:1416-1423.
46. Taniguchi Y, Furukawa T, Tun T, Han H, Honjo T. 1998. LIM protein KyoT2 negatively regulates transcription by association with the RBP-J DNA-binding protein. Mol. Cell. Biol. 18:644-654.
47. Verma SC, Borah S, Robertson ES. 2004. Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus up-regulates transcription of human telomerase reverse transcriptase promoter through interaction with transcription factor Sp1. J. Virol. 78:10348-10359.
48. Ye F-C, et al. 2004. Disruption of Kaposi's sarcoma-associated herpesvirus latent nuclear antigen leads to abortive episome persistence. J. Virol. 78:11121-11129.