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Volumn 86, Issue 9, 2012, Pages 5352-5365

Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) and LMP2A function cooperatively to promote carcinoma development in a mouse carcinogenesis model

Author keywords

[No Author keywords available]

Indexed keywords

LATENT MEMBRANE PROTEIN 1; LATENT MEMBRANE PROTEIN 2A; MITOGEN ACTIVATED PROTEIN KINASE; STAT3 PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

EID: 84861312893     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.07035-11     Document Type: Article
Times cited : (47)

References (56)
  • 1
    • 0020586334 scopus 로고
    • Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene
    • Balmain A, Pragnell IB. 1983. Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene. Nature 303:72-74.
    • (1983) Nature , vol.303 , pp. 72-74
    • Balmain, A.1    Pragnell, I.B.2
  • 3
    • 0033981052 scopus 로고    scopus 로고
    • Epstein-Barr virus LMP2A-induced B-cell survival in two unique classes of EmuLMP2A transgenic mice
    • Caldwell RG, Brown RC, Longnecker R. 2000. Epstein-Barr virus LMP2A-induced B-cell survival in two unique classes of EmuLMP2A transgenic mice. J. Virol. 74:1101-1113.
    • (2000) J. Virol. , vol.74 , pp. 1101-1113
    • Caldwell, R.G.1    Brown, R.C.2    Longnecker, R.3
  • 4
    • 0032169313 scopus 로고    scopus 로고
    • Epstein-Barr virus LMP2A drives B cell development and survival in the absence of normal B cell receptor signals
    • Caldwell RG, Wilson JB, Anderson SJ, Longnecker R. 1998. Epstein-Barr virus LMP2A drives B cell development and survival in the absence of normal B cell receptor signals. Immunity 9:405-411.
    • (1998) Immunity , vol.9 , pp. 405-411
    • Caldwell, R.G.1    Wilson, J.B.2    Anderson, S.J.3    Longnecker, R.4
  • 5
    • 1942538505 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-mediated activation of Stat3 during multistage skin carcinogenesis
    • Chan KS, et al. 2004. Epidermal growth factor receptor-mediated activation of Stat3 during multistage skin carcinogenesis. Cancer Res. 64:2382-2389.
    • (2004) Cancer Res , vol.64 , pp. 2382-2389
    • Chan, K.S.1
  • 6
    • 4944239032 scopus 로고    scopus 로고
    • Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis
    • Chan KS, et al. 2004. Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis. J. Clin. Invest. 114:720-728.
    • (2004) J. Clin. Invest. , vol.114 , pp. 720-728
    • Chan, K.S.1
  • 7
    • 34548081381 scopus 로고    scopus 로고
    • Latent membrane protein 1-induced EGFR signalling is negatively regulated by TGF alpha prior to neoplasia
    • Charalambous CT, Hannigan A, Tsimbouri P, McPhee GM, Wilson JB. 2007. Latent membrane protein 1-induced EGFR signalling is negatively regulated by TGF alpha prior to neoplasia. Carcinogenesis 28:1839-1848.
    • (2007) Carcinogenesis , vol.28 , pp. 1839-1848
    • Charalambous, C.T.1    Hannigan, A.2    Tsimbouri, P.3    McPhee, G.M.4    Wilson, J.B.5
  • 8
    • 0035884394 scopus 로고    scopus 로고
    • Epstein-Barr virus encoded latent membrane protein-1 induces epithelial cell proliferation and sensitizes transgenic mice to chemical carcinogenesis
    • Curran JA, Laverty FS, Campbell D, Macdiarmid J, Wilson JB. 2001. Epstein-Barr virus encoded latent membrane protein-1 induces epithelial cell proliferation and sensitizes transgenic mice to chemical carcinogenesis. Cancer Res. 61:6730-6738.
    • (2001) Cancer Res , vol.61 , pp. 6730-6738
    • Curran, J.A.1    Laverty, F.S.2    Campbell, D.3    Macdiarmid, J.4    Wilson, J.B.5
  • 9
    • 41149159605 scopus 로고    scopus 로고
    • Epstein-Barr virus-encoded LMP1 regulates epithelial cell motility and invasion via the ERK-MAPK pathway
    • Dawson CW, Laverick L, Morris MA, Tramoutanis G, Young LS. 2008. Epstein-Barr virus-encoded LMP1 regulates epithelial cell motility and invasion via the ERK-MAPK pathway. J. Virol. 82:3654-3664.
    • (2008) J. Virol. , vol.82 , pp. 3654-3664
    • Dawson, C.W.1    Laverick, L.2    Morris, M.A.3    Tramoutanis, G.4    Young, L.S.5
  • 10
    • 0037423201 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein 1 (LMP1) activates the phosphatidylinositol 3-kinase/Akt pathway to promote cell survival and induce actin filament remodeling
    • Dawson CW, Tramountanis G, Eliopoulos AG, Young LS. 2003. Epstein-Barr virus latent membrane protein 1 (LMP1) activates the phosphatidylinositol 3-kinase/Akt pathway to promote cell survival and induce actin filament remodeling. J. Biol. Chem. 278:3694-3704.
    • (2003) J. Biol. Chem. , vol.278 , pp. 3694-3704
    • Dawson, C.W.1    Tramountanis, G.2    Eliopoulos, A.G.3    Young, L.S.4
  • 11
    • 33947599292 scopus 로고    scopus 로고
    • Cholesterol is critical for Epstein-Barr virus latent membrane protein 2A trafficking and protein stability
    • Ikeda M, Longnecker R. 2007. Cholesterol is critical for Epstein-Barr virus latent membrane protein 2A trafficking and protein stability. Virology 360:461-468.
    • (2007) Virology , vol.360 , pp. 461-468
    • Ikeda, M.1    Longnecker, R.2
  • 12
    • 0034659849 scopus 로고    scopus 로고
    • Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis
    • Ise K, et al. 2000. Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis. Oncogene 19:2951-2956.
    • (2000) Oncogene , vol.19 , pp. 2951-2956
    • Ise, K.1
  • 13
    • 0032578485 scopus 로고    scopus 로고
    • Expression of the Epstein-Barr virus latent membrane protein 1 induces B cell lymphoma in transgenic mice
    • Kulwichit W, et al. 1998. Expression of the Epstein-Barr virus latent membrane protein 1 induces B cell lymphoma in transgenic mice. Proc. Natl. Acad. Sci. U. S. A. 95:11963-11968.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 11963-11968
    • Kulwichit, W.1
  • 14
    • 79955368240 scopus 로고    scopus 로고
    • Epstein-Barr virus LMP1 activates EGFR, STAT3, and ERK through effects on PKCdelta
    • Kung CP, Meckes DG, Jr, Raab-Traub N. 2011. Epstein-Barr virus LMP1 activates EGFR, STAT3, and ERK through effects on PKCdelta. J. Virol. 85:4399-4408.
    • (2011) J. Virol. , vol.85 , pp. 4399-4408
    • Kung, C.P.1    Meckes Jr., D.G.2    Raab-Traub, N.3
  • 15
    • 43949130116 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein 1 induces expression of the epidermal growth factor receptor through effects on Bcl-3 and STAT3
    • Kung CP, Raab-Traub N. 2008. Epstein-Barr virus latent membrane protein 1 induces expression of the epidermal growth factor receptor through effects on Bcl-3 and STAT3. J. Virol. 82:5486-5493.
    • (2008) J. Virol. , vol.82 , pp. 5486-5493
    • Kung, C.P.1    Raab-Traub, N.2
  • 16
    • 35148856846 scopus 로고    scopus 로고
    • Reduced expression of RASSF1A in esophageal and nasopharyngeal carcinomas significantly correlates with tumor stage
    • Lo PH, et al. 2007. Reduced expression of RASSF1A in esophageal and nasopharyngeal carcinomas significantly correlates with tumor stage. Cancer Lett. 257:199-205.
    • (2007) Cancer Lett , vol.257 , pp. 199-205
    • Lo, P.H.1
  • 17
    • 0033825005 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein 2A has no growth-altering effects when expressed in differentiating epithelia
    • Longan L, Longnecker R. 2000. Epstein-Barr virus latent membrane protein 2A has no growth-altering effects when expressed in differentiating epithelia. J. Gen. Virol. 81:2245-2252.
    • (2000) J. Gen. Virol. , vol.81 , pp. 2245-2252
    • Longan, L.1    Longnecker, R.2
  • 18
    • 33646847002 scopus 로고    scopus 로고
    • Syk tyrosine kinase mediates Epstein-Barr virus latent membrane protein 2A-induced cell migration in epithelial cells
    • Lu J, et al. 2006. Syk tyrosine kinase mediates Epstein-Barr virus latent membrane protein 2A-induced cell migration in epithelial cells. J. Biol. Chem. 281:8806-8814.
    • (2006) J. Biol. Chem. , vol.281 , pp. 8806-8814
    • Lu, J.1
  • 19
    • 36349031033 scopus 로고    scopus 로고
    • Activation of epidermal akt by diverse mouse skin tumor promoters
    • Lu J, Rho O, Wilker E, Beltran L, Digiovanni J. 2007. Activation of epidermal akt by diverse mouse skin tumor promoters. Mol. Cancer Res. 5:1342-1352.
    • (2007) Mol. Cancer Res. , vol.5 , pp. 1342-1352
    • Lu, J.1    Rho, O.2    Wilker, E.3    Beltran, L.4    Digiovanni, J.5
  • 20
    • 0141482027 scopus 로고    scopus 로고
    • Akt as a mediator of cell death
    • Luo HR, et al. 2003. Akt as a mediator of cell death. Proc. Natl. Acad. Sci. U. S. A. 100:11712-11717.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 11712-11717
    • Luo, H.R.1
  • 21
    • 0042168998 scopus 로고    scopus 로고
    • The latent membrane protein 1 of Epstein-Barr virus and loss of the INK4a locus: paradoxes resolve to cooperation in carcinogenesis in vivo
    • Macdiarmid J, Stevenson D, Campbell DH, Wilson JB. 2003. The latent membrane protein 1 of Epstein-Barr virus and loss of the INK4a locus: paradoxes resolve to cooperation in carcinogenesis in vivo. Carcinogenesis 24:1209-1218.
    • (2003) Carcinogenesis , vol.24 , pp. 1209-1218
    • Macdiarmid, J.1    Stevenson, D.2    Campbell, D.H.3    Wilson, J.B.4
  • 22
    • 27144542052 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein 1 CTAR1 mediates rodent and human fibroblast transformation through activation of PI3K
    • Mainou BA, Everly DN, Jr, Raab-Traub N. 2005. Epstein-Barr virus latent membrane protein 1 CTAR1 mediates rodent and human fibroblast transformation through activation of PI3K. Oncogene 24:6917-6924.
    • (2005) Oncogene , vol.24 , pp. 6917-6924
    • Mainou, B.A.1    Everly Jr., D.N.2    Raab-Traub, N.3
  • 23
    • 34248368436 scopus 로고    scopus 로고
    • Latent membrane protein 1 suppresses RASSF1A expression, disrupts microtubule structures and induces chromosomal aberrations in human epithelial cells
    • Man C, et al. 2007. Latent membrane protein 1 suppresses RASSF1A expression, disrupts microtubule structures and induces chromosomal aberrations in human epithelial cells. Oncogene 26:3069-3080.
    • (2007) Oncogene , vol.26 , pp. 3069-3080
    • Man, C.1
  • 24
    • 0025055144 scopus 로고
    • Analysis of serial measurements in medical research
    • Matthews JN, Altman DG, Campbell MJ, Royston P. 1990. Analysis of serial measurements in medical research. BMJ 300:230-235.
    • (1990) BMJ , vol.300 , pp. 230-235
    • Matthews, J.N.1    Altman, D.G.2    Campbell, M.J.3    Royston, P.4
  • 25
    • 34447129574 scopus 로고    scopus 로고
    • Human papillomavirus 16 E5 oncogene contributes to two stages of skin carcinogenesis
    • Maufort JP, Williams SM, Pitot HC, Lambert PF. 2007. Human papillomavirus 16 E5 oncogene contributes to two stages of skin carcinogenesis. Cancer Res. 67:6106-6112.
    • (2007) Cancer Res , vol.67 , pp. 6106-6112
    • Maufort, J.P.1    Williams, S.M.2    Pitot, H.C.3    Lambert, P.F.4
  • 26
    • 78650553841 scopus 로고    scopus 로고
    • Human tumor virus utilizes exosomes for intercellular communication
    • Meckes DG, Jr, et al. 2010. Human tumor virus utilizes exosomes for intercellular communication. Proc. Natl. Acad. Sci. U. S. A. 107:20370-20375.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 20370-20375
    • Meckes Jr., D.G.1
  • 27
    • 18844372276 scopus 로고    scopus 로고
    • Tumor necrosis factor-{alpha} decreases Akt protein levels in 3T3-L1 adipocytes via the caspase-dependent ubiquitination of Akt
    • Medina EA, et al. 2005. Tumor necrosis factor-{alpha} decreases Akt protein levels in 3T3-L1 adipocytes via the caspase-dependent ubiquitination of Akt. Endocrinology 146:2726-2735.
    • (2005) Endocrinology , vol.146 , pp. 2726-2735
    • Medina, E.A.1
  • 28
    • 0031823657 scopus 로고    scopus 로고
    • Analysis of ras gene mutational spectra in epidermal papillomas from K6/ODC transgenic mice
    • Megosh L, Halpern M, Farkash E, O'Brien TG. 1998. Analysis of ras gene mutational spectra in epidermal papillomas from K6/ODC transgenic mice. Mol. Carcinog. 22:145-149.
    • (1998) Mol. Carcinog. , vol.22 , pp. 145-149
    • Megosh, L.1    Halpern, M.2    Farkash, E.3    O'Brien, T.G.4
  • 29
    • 0028970289 scopus 로고
    • Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases
    • Miller CL, et al. 1995. Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases. Immunity 2:155-166.
    • (1995) Immunity , vol.2 , pp. 155-166
    • Miller, C.L.1
  • 30
    • 0028088994 scopus 로고
    • An integral membrane protein (LMP2) blocks reactivation of Epstein-Barr virus from latency following surface immunoglobulin crosslinking
    • Miller CL, Lee JH, Kieff E, Longnecker R. 1994. An integral membrane protein (LMP2) blocks reactivation of Epstein-Barr virus from latency following surface immunoglobulin crosslinking. Proc. Natl. Acad. Sci. U. S. A. 91:772-776.
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 772-776
    • Miller, C.L.1    Lee, J.H.2    Kieff, E.3    Longnecker, R.4
  • 31
    • 70349210826 scopus 로고    scopus 로고
    • Role of the Epstein-Barr virus-encoded latent membrane protein-1, LMP1, in the pathogenesis of nasopharyngeal carcinoma
    • Morris MA, Dawson CW, Young LS. 2009. Role of the Epstein-Barr virus-encoded latent membrane protein-1, LMP1, in the pathogenesis of nasopharyngeal carcinoma. Future Oncol. 5:811-825.
    • (2009) Future Oncol , vol.5 , pp. 811-825
    • Morris, M.A.1    Dawson, C.W.2    Young, L.S.3
  • 32
    • 3442878123 scopus 로고    scopus 로고
    • Differential signaling pathways are activated in the Epstein-Barr virusassociated malignancies nasopharyngeal carcinoma and Hodgkin lymphoma
    • Morrison JA, Gulley ML, Pathmanathan R, Raab-Traub N. 2004. Differential signaling pathways are activated in the Epstein-Barr virusassociated malignancies nasopharyngeal carcinoma and Hodgkin lymphoma. Cancer Res. 64:5251-5260.
    • (2004) Cancer Res , vol.64 , pp. 5251-5260
    • Morrison, J.A.1    Gulley, M.L.2    Pathmanathan, R.3    Raab-Traub, N.4
  • 33
    • 0242363228 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein 2A activates beta-catenin signaling in epithelial cells
    • Morrison JA, Klingelhutz AJ, Raab-Traub N. 2003. Epstein-Barr virus latent membrane protein 2A activates beta-catenin signaling in epithelial cells. J. Virol. 77:12276-12284.
    • (2003) J. Virol. , vol.77 , pp. 12276-12284
    • Morrison, J.A.1    Klingelhutz, A.J.2    Raab-Traub, N.3
  • 34
    • 29744450125 scopus 로고    scopus 로고
    • Epstein-Barr-virus-encoded LMP2A induces primary epithelial cell migration and invasion: possible role in nasopharyngeal carcinoma metastasis
    • Pegtel DM, et al. 2005. Epstein-Barr-virus-encoded LMP2A induces primary epithelial cell migration and invasion: possible role in nasopharyngeal carcinoma metastasis. J. Virol. 79:15430-15442.
    • (2005) J. Virol. , vol.79 , pp. 15430-15442
    • Pegtel, D.M.1
  • 35
    • 9644279753 scopus 로고    scopus 로고
    • Epstein-Barr virus (EBV) LMP2A mediates B-lymphocyte survival through constitutive activation of the Ras/PI3K/Akt pathway
    • Portis T, Longnecker R. 2004. Epstein-Barr virus (EBV) LMP2A mediates B-lymphocyte survival through constitutive activation of the Ras/PI3K/Akt pathway. Oncogene 23:8619-8628.
    • (2004) Oncogene , vol.23 , pp. 8619-8628
    • Portis, T.1    Longnecker, R.2
  • 36
    • 0022527161 scopus 로고
    • Carcinogenspecific mutation and amplification of Ha-ras during mouse skin carcinogenesis
    • Quintanilla M, Brown K, Ramsden M, Balmain A. 1986. Carcinogenspecific mutation and amplification of Ha-ras during mouse skin carcinogenesis. Nature 322:78-80.
    • (1986) Nature , vol.322 , pp. 78-80
    • Quintanilla, M.1    Brown, K.2    Ramsden, M.3    Balmain, A.4
  • 37
    • 0036435166 scopus 로고    scopus 로고
    • Epstein-Barr virus in the pathogenesis of NPC
    • Raab-Traub N. 2002. Epstein-Barr virus in the pathogenesis of NPC. Semin. Cancer Biol. 12:431-441.
    • (2002) Semin. Cancer Biol. , vol.12 , pp. 431-441
    • Raab-Traub, N.1
  • 38
    • 0030267198 scopus 로고    scopus 로고
    • Pathogenesis of Epstein-Barr virus and its associated malignancies
    • Raab-Traub N. 1996. Pathogenesis of Epstein-Barr virus and its associated malignancies. Semin. Virol. 7:315-323.
    • (1996) Semin. Virol. , vol.7 , pp. 315-323
    • Raab-Traub, N.1
  • 39
    • 0034078146 scopus 로고    scopus 로고
    • Frequent codon 12 Ki-ras mutations in mouse skin tumors initiated by N-methyl-N'-nitro-N-nitrosoguanidine and promoted by mezerein
    • Rehman I, et al. 2000. Frequent codon 12 Ki-ras mutations in mouse skin tumors initiated by N-methyl-N=-nitro-N-nitrosoguanidine and promoted by mezerein. Mol. Carcinog. 27:298-307.
    • (2000) Mol. Carcinog. , vol.27 , pp. 298-307
    • Rehman, I.1
  • 40
    • 0038645387 scopus 로고    scopus 로고
    • H-ras mutations at codon 61 or 13 in tumors initiated with aNOdonor in mouse skin
    • Satomi Y, Bu P, Okuda M, Tokuda H, Nishino H. 2003. H-ras mutations at codon 61 or 13 in tumors initiated with aNOdonor in mouse skin. Cancer Lett. 196:17-22.
    • (2003) Cancer Lett , vol.196 , pp. 17-22
    • Satomi, Y.1    Bu, P.2    Okuda, M.3    Tokuda, H.4    Nishino, H.5
  • 41
    • 0033756107 scopus 로고    scopus 로고
    • Epstein-Barr virus LMP2A transforms epithelial cells, inhibits cell differentiation, and activates Akt
    • Scholle F, Bendt KM, Raab-Traub N. 2000. Epstein-Barr virus LMP2A transforms epithelial cells, inhibits cell differentiation, and activates Akt. J. Virol. 74:10681-10689.
    • (2000) J. Virol. , vol.74 , pp. 10681-10689
    • Scholle, F.1    Bendt, K.M.2    Raab-Traub, N.3
  • 42
    • 36348947025 scopus 로고    scopus 로고
    • Deregulated activity of Akt in epithelial basal cells induces spontaneous tumors and heightened sensitivity to skin carcinogenesis
    • Segrelles C, et al. 2007. Deregulated activity of Akt in epithelial basal cells induces spontaneous tumors and heightened sensitivity to skin carcinogenesis. Cancer Res. 67:10879-10888.
    • (2007) Cancer Res , vol.67 , pp. 10879-10888
    • Segrelles, C.1
  • 43
    • 0037012011 scopus 로고    scopus 로고
    • Functional roles of Akt signaling in mouse skin tumorigenesis
    • Segrelles C, et al. 2002. Functional roles of Akt signaling in mouse skin tumorigenesis. Oncogene 21:53-64.
    • (2002) Oncogene , vol.21 , pp. 53-64
    • Segrelles, C.1
  • 44
    • 37349127804 scopus 로고    scopus 로고
    • EBV latent membrane protein 1 activates Akt, NFkappaB, and Stat3 in B cell lymphomas
    • Shair KH, et al. 2007. EBV latent membrane protein 1 activates Akt, NFkappaB, and Stat3 in B cell lymphomas. PLoS Pathog. 3:e166.
    • (2007) PLoS Pathog , vol.3
    • Shair, K.H.1
  • 45
    • 52049090124 scopus 로고    scopus 로고
    • EBV latent membrane protein 1 effects on plakoglobin, cell growth, and migration
    • Shair KH, Schnegg CI, Raab-Traub N. 2008. EBV latent membrane protein 1 effects on plakoglobin, cell growth, and migration. Cancer Res. 68:6997-7005.
    • (2008) Cancer Res , vol.68 , pp. 6997-7005
    • Shair, K.H.1    Schnegg, C.I.2    Raab-Traub, N.3
  • 46
    • 67651006731 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein-1 effects on junctional plakoglobin and induction of a cadherin switch
    • Shair KH, Schnegg CI, Raab-Traub N. 2009. Epstein-Barr virus latent membrane protein-1 effects on junctional plakoglobin and induction of a cadherin switch. Cancer Res. 69:5734-5742.
    • (2009) Cancer Res , vol.69 , pp. 5734-5742
    • Shair, K.H.1    Schnegg, C.I.2    Raab-Traub, N.3
  • 47
    • 0034652546 scopus 로고    scopus 로고
    • Human papillomavirus types 16 E6 and E7 contribute differently to carcinogenesis
    • Song S, Liem A, Miller JA, Lambert PF. 2000. Human papillomavirus types 16 E6 and E7 contribute differently to carcinogenesis. Virology 267: 141-150.
    • (2000) Virology , vol.267 , pp. 141-150
    • Song, S.1    Liem, A.2    Miller, J.A.3    Lambert, P.F.4
  • 48
    • 25444522470 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein 1 (CAO) up-regulates VEGF and TGF alpha concomitant with hyperlasia, with subsequent up-regulation of p16 and MMP9
    • Stevenson D, Charalambous C, Wilson JB. 2005. Epstein-Barr virus latent membrane protein 1 (CAO) up-regulates VEGF and TGF alpha concomitant with hyperlasia, with subsequent up-regulation of p16 and MMP9. Cancer Res. 65:8826-8835.
    • (2005) Cancer Res , vol.65 , pp. 8826-8835
    • Stevenson, D.1    Charalambous, C.2    Wilson, J.B.3
  • 49
    • 0346365370 scopus 로고    scopus 로고
    • Activation of nuclear factor-kappaB p50 homodimer/Bcl-3 complexes in nasopharyngeal carcinoma
    • Thornburg NJ, Pathmanathan R, Raab-Traub N. 2003. Activation of nuclear factor-kappaB p50 homodimer/Bcl-3 complexes in nasopharyngeal carcinoma. Cancer Res. 63:8293-8301.
    • (2003) Cancer Res , vol.63 , pp. 8293-8301
    • Thornburg, N.J.1    Pathmanathan, R.2    Raab-Traub, N.3
  • 51
    • 0033536591 scopus 로고    scopus 로고
    • Mimicry of CD40 signals by Epstein-Barr virus LMP1 in B lymphocyte responses
    • Uchida J, et al. 1999. Mimicry of CD40 signals by Epstein-Barr virus LMP1 in B lymphocyte responses. Science 286:300-303.
    • (1999) Science , vol.286 , pp. 300-303
    • Uchida, J.1
  • 52
    • 0025325578 scopus 로고
    • Expression of the BNLF-1 oncogene of Epstein-Barr virus in the skin of transgenic mice induces hyperplasia and aberrant expression of keratin 6
    • Wilson JB, Weinberg W, Johnson R, Yuspa S, Levine AJ. 1990. Expression of the BNLF-1 oncogene of Epstein-Barr virus in the skin of transgenic mice induces hyperplasia and aberrant expression of keratin 6. Cell 61:1315-1327.
    • (1990) Cell , vol.61 , pp. 1315-1327
    • Wilson, J.B.1    Weinberg, W.2    Johnson, R.3    Yuspa, S.4    Levine, A.J.5
  • 53
    • 4544286927 scopus 로고    scopus 로고
    • Strain-dependent differences in malignant conversion of mouse skin tumors is an inherent property of the epidermal keratinocyte
    • Woodworth CD, et al. 2004. Strain-dependent differences in malignant conversion of mouse skin tumors is an inherent property of the epidermal keratinocyte. Carcinogenesis 25:1771-1778.
    • (2004) Carcinogenesis , vol.25 , pp. 1771-1778
    • Woodworth, C.D.1
  • 54
    • 0042467687 scopus 로고    scopus 로고
    • Epstein-Barr virus and oncogenesis: from latent genes to tumours
    • Young LS, Murray PG. 2003. Epstein-Barr virus and oncogenesis: from latent genes to tumours. Oncogene 22:5108-5121.
    • (2003) Oncogene , vol.22 , pp. 5108-5121
    • Young, L.S.1    Murray, P.G.2
  • 56
    • 0028351556 scopus 로고
    • The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis-thirty-third G. H. A. Clowes Memorial Award Lecture
    • Yuspa SH. 1994. The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis-thirty-third G. H. A. Clowes Memorial Award Lecture. Cancer Res. 54:1178-1189.
    • (1994) Cancer Res , vol.54 , pp. 1178-1189
    • Yuspa, S.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.