Sensitive determination of prohibited drugs in dried blood spots (DBS) for doping controls by means of a benchtop quadrupole/Orbitrap mass spectrometer

Analytical and Bioanalytical Chemistry

Volumn 403, Issue 5, 2012, Pages 1279-1289

  Thomas, Andreas ^a   Geyer, Hans ^a   Schänzer, Wilhelm ^a   Crone, Catharina ^b   Kellmann, Markus ^b   Moehring, Thomas ^b   Thevis, Mario ^a  

^a GERMAN SPORT UNIVERSITY COLOGNE   (Germany)

^b THERMO FISHER SCIENTIFIC   (Germany)

Author keywords

Blood analysis; QExactive; Sports drug testing; Unknown screening

Indexed keywords

ANALYTES; ANDROGEN RECEPTORS; BISOPROLOL; BLOOD ANALYSIS; CLENBUTEROL; DATA EVALUATION; DEXAMETHASONES; DOPING CONTROL; DRIED BLOOD SPOTS; DRUG TESTING; FORMOTEROL; HIGH RESOLUTION; HYDROCHLOROTHIAZIDE; INTERNAL STANDARDS; ION MASS; ION SUPPRESSION; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHIC SEPARATIONS; METHYLPHENIDATE; METOPROLOL; MODEL COMPOUND; NIKETHAMIDE; NON-TARGETED; ORBITRAP; QEXACTIVE; QUADRUPOLE MASS FILTERS; QUADRUPOLES; QUANTITATIVE RESULT; RETENTION TIME; SALBUTAMOL; SAMPLE PREPARATION; STANOZOLOL; TARGET ANALYTES;

CARBOXYLIC ACIDS; CHEMICAL ANALYSIS; DEUTERIUM; DRUG PRODUCTS; ELECTROSPRAY IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; ORGANIC SOLVENTS; SPORTS; STANDARDS;

BLOOD;

PERFORMANCE ENHANCING SUBSTANCE;

ARTICLE; BLOOD; DOPING; EVALUATION; HUMAN; MASS SPECTROMETRY; METHODOLOGY; SENSITIVITY AND SPECIFICITY; SUBSTANCE ABUSE;

DOPING IN SPORTS; HUMANS; MASS SPECTROMETRY; PERFORMANCE-ENHANCING SUBSTANCES; SENSITIVITY AND SPECIFICITY; SUBSTANCE ABUSE DETECTION;

STRYCHNOS TOXIFERA;

EID: 84861231627     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-011-5655-2     Document Type: Article

References (43)

1. Danaceau JP, Scott Morrison M, Slawson MH (2008) J Mass Spectrom 43:993-1000
2. Moulard Y, Bailly-Chouriberry L, Boyer S, Garcia P, Popot MA, Bonnaire Y (2011) Anal Chim Acta 700:126-136
3. Clarke A, Scarth J, Teale P, Pearce C, Hillyer L (2011) Drug Test Anal 3:74-87
4. Jiwan JL, Wallemacq P, Herent MF(2011) Clin Biochem44:136-147
5. Thomas A, Guddat S, Kohler M, Krug O, Schänzer W, Petrou M, Thevis M (2010) Rapid Commun Mass Spectrom 24:1124-1132
6. Thomas A, Höppner S, Geyer H, SchänzerW, Petrou M, Kwiatkowska D, Pokrywka A, Thevis M (2011) Anal Bioanal Chem 401:507-516
7. Thomas A, Kohler M, Mester J, Geyer H, Schänzer W, Petrou M, Thevis M (2010) Drug Test Anal 2:144-148
8. Peters FT (2011) Clin Biochem 44:54-65
9. Maurer HH (2011) Ther Drug Monit 32:324-327
10. Thevis M, Makarov AA, Horning S, Schänzer W (2005) Rapid Commun Mass Spectrom 19:3369-3378
11. Michalski A, Damoc E, Hauschild JP, Lange O, Wieghaus A, Makarov A, Nagaraj N, Cox J, Mann M, Horning S Mol Cell Proteomics 10: doi:10.1074/mcp. M111.011015
12. Scigelova M, Hornshaw M, Giannakopulos A, Makarov A (2011) Mol Cell Proteomics 10: doi: 10.1074/mcp.M111.009431
13. Thomas A, Geyer H, Guddat S, Schänzer W, Thevis M Drug Test Anal doi:10.1002/dta.342
14. Abu-Rabie P, Spooner N (2009) Anal Chem 81:10275-10284
15. Aldenhoven M, de Koning TJ, Verheijen FW, Prinsen BH, Wijburg FA, van der Ploeg AT, de Sain-van der Velden MG, Boelens J (2010) Biol Blood Marrow Transplant 16:701-704
16. Carducci C, Santagata S, Leuzzi V, Artiola C, Giovanniello T, Battini R, Antonozzi I (2006) Clin Chim Acta 364:180-187
17. Clavijo CF, Hoffman KL, Thomas JJ, Carvalho B, Chu LF, Drover DR, Hammer GB, Christians U, Galinkin JL (2011) Anal Bioanal Chem 400:715-728
18. Deglon J, Lauer E, Thomas A, Mangin P, Staub C (2010) Anal Bioanal Chem 396:2523-2532
19. Deglon J, Thomas A, Cataldo A, Mangin P, Staub C (2009) J Pharm Biomed Anal 49:1034-1039
20. Li W, Tse FL (2010) Biomed Chromatogr 24:49-65
21. Mather J, Rainville PD, Spooner N, Evans CA, Smith NW, Plumb RS (2011) Bioanalysis 3:411-420
22. McDade TW, Williams S, Snodgrass JJ (2007) Demography 44:899-925
23. Parker DR, Bargiota A, Cowan FJ, Corrall RJ (1997) Clin Endocrinol (Oxf) 47:679-683
24. Patel P, Tanna S, Mulla H, Kairamkonda V, Pandya H, Lawson G (2010) J Chromatogr B Analyt Technol Biomed Life Sci 878:3277-3282
25. Therrell BL, Hannon WH, Pass KA, Lorey F, Brokopp C, Eckman J, Glass M, Heidenreich R, Kinney S, Kling S, Landenburger G, Meaney FJ, McCabe ER, Panny S, Schwartz M, Shapira E (1996) Biochem Mol Med 57:116-124
26. Wong P, Pham R, Bruenner BA, James CA (2010) Bioanalysis 2:1787-1789
27. Thevis M, Thomas A, Fusshöller G, Beuck S, Geyer H, Schänzer W (2010) Rapid Commun Mass Spectrom 24:2245-2254
28. Thevis M, Geyer H, Kamber M, Schänzer W (2009) Drug Test Anal 1:387-392
29. Matuszewski BK, Constanzer ML, Chavez-Eng CM (2003) Anal Chem 75:3019-3030
30. Brenneisen R, Meyer P, Chtioui H, Saugy M, Kamber M (2010) Anal Bioanal Chem 396:2493-2502
31. König S, Aebi B, Lanz S, Gasser M, Weinmann W (2011) Anal Bioanal Chem 400:9-16
32. Schwope DM, Scheidweiler KB, Huestis MA (2011) Anal Bioanal Chem 401:1273-1283
33. Zhang H, Zhu M, Ray KL, Ma L, Zhang D (2008) Rapid Commun Mass Spectrom 22:2082-2088
34. http://www.wada-ama.org/en/World-Anti-Doping-Program/Sports-and-Anti- Doping-Organizations/International-Standards/Prohibited-List/(2011) Vol. 2011, WADA
35. Saugy M, Robinson N, Saudan C (2009) Drug Test Anal 1:474-478
36. http://www.wada-ama.org/Documents/World-Anti-Doping-Program/ WADP-IS-Laboratories/WADA-Int.Standard-Laboratories-2009-EN.pdf (2011) Vol. 2011, WADA
37. Thevis M (2010) Mass spectrometry in sports drug testing. Wiley, New Jersey
38. Spooner N, Ramakrishnan Y, Barfield M, Dewit O, Miller S (2011) Bioanalysis 2:1515-1522
39. Denniff P, Spooner N (2011) Bioanalysis 2:1385-1395
40. Abu-Rabie P, Spooner N (2011) Bioanalysis 2:1373-1384
41. Youhnovski N, Bergeron A, Furtado M, Garofolo F (2011) Rapid Commun Mass Spectrom 25:2951-2958
42. Thevis M, Thomas A, Kohler M, Beuck S, Schänzer W (2009) J Mass Spectrom 44:442-460
43. Thevis M, Schänzer W (2007) Mini Rev Med Chem 7:531-537