The selective cyclooxygenase-2 inhibitor parecoxib markedly improves the ability of the duodenum to regulate luminal hypertonicity in anaesthetized rats

Acta Physiologica

Volumn 205, Issue 3, 2012, Pages 433-451

  Sedin, J ^a   Sjoblom M ^a   Nylander, O ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Hexamethonium; Mecamylamine; Motility; Mucosal permeability; Osmolality; Secretion

Indexed keywords

HEXAMETHONIUM; MECAMYLAMINE; PARECOXIB;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DUODENUM; MALE; MUSCLE HYPERTONIA; NONHUMAN; OSMOLALITY; POSTOPERATIVE ILEUS; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING;

ANIMALS; CYCLOOXYGENASE 2 INHIBITORS; DUODENUM; ISOXAZOLES; MALE; MODELS, ANIMAL; MUSCLE CONTRACTION; MUSCLE HYPERTONIA; MUSCLE, SMOOTH; OSMOLAR CONCENTRATION; RATS; RATS, INBRED STRAINS; RECEPTORS, NICOTINIC; REGRESSION ANALYSIS; SALINE SOLUTION, HYPERTONIC; UNCONSCIOUSNESS;

EID: 84861231488     PISSN: 17481708     EISSN: 17481716     Source Type: Journal    
DOI: 10.1111/j.1748-1716.2012.02411.x     Document Type: Article

References (50)

1. Anderson, J.M. & Van Itallie, C.M. 2009. Physiology and function of the tight junction. Cold Spring Harb Perspect Biol 1, a002584.
2. Armstrong, W. 1987. Cellular mechanisms of ion transport in the small intestine. In: Johnson L.R. (ed.) Physiology of the Gastrointestinal Tract, 2nd edn, pp. 1251-1265. Raven press, New York, NY.
3. Boeckxstaens, G.E. & de Jonge, W.J. 2009. Neuroimmune mechanisms in postoperative ileus. Gut 58, 1300-1311.
4. Bueno, L., Ferre, J.P. & Ruckebusch, Y. 1978. Effects of anesthesia and surgical procedures on intestinal myoelectric activity in rats. Am J Dig Dis 23, 690-695.
5. Crissinger, K.D., Kvietys, P.R. & Granger, D.N. 1990. Pathophysiology of gastrointestinal mucosal permeability. J Intern Med Suppl 732, 145-154.
6. Curran, P.F. & Solomon, A.K. 1957. Ion and water fluxes in the ileum of rats. J Gen Physiol 41, 143-168.
7. Diamond, J.M. 1966. Non-linear osmosis. J Physiol 183, 58-82.
8. Fihn, B.M., Sjöqvist, A. & Jodal, M. 2000. Permeability of the rat small intestinal epithelium along the villus-crypt axis: effects of glucose transport. Gastroenterology 119, 1029-1036.
9. Fordtran, J.S., Rector, F.C., Ewton, M.F., Soter, N. & Kinney, J. 1965. Permeability characteristics of human small intestine. J Clin Invest 44, 1935-1944.
10. Gregory, P.C., Rayner, D.V. & Wenham, G. 1984. Initiation of migrating myoelectric complex in sheep by duodenal acidification and hyperosmolarity: role of vagus nerves. J Physiol 355, 509-521.
11. Harris, M.S. & Kennedy, J.G. 1988. Relationship between distention and absorption in rat intestine. II. Effects of volume and flow rate on transport. Gastroenterology 94, 1172-1179.
12. Harris, M.S., Kennedy, J.G., Siegesmund, K.A. & Yorde, D.E. 1988. Relationship between distention and absorption in rat intestine. I. Effect of luminal volume on the morphology of the absorbing surface. Gastroenterology 94, 1164-1171.
13. Hindle, W. & Code, C.F. 1962. Some differences between duodenal and ileal sorption. Am J Physiol 203, 215-220.
14. Jenkins, R.T. & Bell, R.A. 1987. Molecular radii of probes used in studies of intestinal permeability. Gut 28, 110-111.
15. Josephs, M.D., Cheng, G., Ksontini, R., Moldawer, L.L. & Hocking, M.P. 1999. Products of cyclooxygenase-2 catalysis regulate postoperative bowel motility. J Surg Res 86, 50-54.
16. Kalantzi, L., Goumas, K., Kalioras, V., Abrahamsson, B., Dressman, J.B. & Reppas, C. 2006. Characterization of the human upper gastrointestinal contents under conditions simulating bioavailability/bioequivalence studies. Pharm Res 23, 165-176.
17. Kalff, J.C., Turler, A., Schwarz, N.T., Schraut, W.H., Lee, K.K., Tweardy, D.J., Billiar, T.R., Simmons, R.L. & Bauer, A.J. 2003. Intra-abdominal activation of a local inflammatory response within the human muscularis externa during laparotomy. Ann Surg 237, 301-315.
18. Lambert, G.P., Chang, R.T., Xia, T., Summers, R.W. & Gisolfi, C.V. 1997. Absorption from different intestinal segments during exercise. J Appl Physiol 83, 204-212.
19. Lin, H.C., Elashoff, J.D., Kwok, G.M., Gu, Y.G. & Meyer, J.H. 1994. Stimulation of duodenal motility by hyperosmolar mannitol depends on local osmoreceptor control. Am J Physiol 266, G940-G943.
20. Loeschke, K., Bentzel, C.J. & Csaky, T.Z. 1970. Asymmetry of osmotic flow in frog intestine: functional and structural correlation. Am J Physiol 218, 1723-1731.
21. Luckhoff, A. & Horster, M. 1981. Hydraulic permeability coefficient and sodium steady-state luminal concentration of the in vivo perfused rat distal colon. Pflugers Arch 391, 301-305.
22. Ma, T.Y. & Anderson, J.M. 2006. Tight junctions and the intestinal barrier. In: L.R. Johnson (ed.) Physiology of the Gastrointestinal Tract, 4th edn, pp. 1559-1594. Elsevier Academic Press, Burlington, MA.
23. Ma, T.Y., Hollander, D., Erickson, R.A., Truong, H. & Krugliak, P. 1991. Is the small intestinal epithelium truly tight to inulin permeation? Am J Physiol 260, G669-G676.
24. Ma, T.Y., Hollander, D., Erickson, R.A., Truong, H., Nguyen, H. & Krugliak, P. 1995. Mechanism of colonic permeation of inulin: is rat colon more permeable than small intestine? Gastroenterology 108, 12-20.
25. Madara, J.L. 1983. Increases in guinea pig small intestinal transepithelial resistance induced by osmotic loads are accompanied by rapid alterations in absorptive-cell tight-junction structure. J Cell Biol 97, 125-136.
26. Mei, N. 1985. Intestinal chemosensitivity. Physiol Rev 65, 211-237.
27. Miller, L.J., Malagelada, J.R. & Go, V.L. 1978. Postprandial duodenal function in man. Gut 19, 699-706.
28. Miller, D.L., Hamburger, S.A. & Schedl, H.P. 1979. Effects of osmotic gradients on water and solute transport: in vivo studies in rat duodenum and ileum. Am J Physiol 237, E389-E396.
29. Naftalin, R.J. & Tripathi, S. 1986. The roles of paracellular and transcellular pathways and submucosal space in isotonic water absorption by rabbit ileum. J Physiol 370, 409-432.
30. Nylander, O. 2011. The impact of cyclooxygenase inhibition on duodenal motility and mucosal alkaline secretion in anaesthetized rats. Acta Physiol (Oxf) 201, 179-192.
31. Nylander, O. & Hällgren, A. 1998. Duodenal mucosal permeability: relevance to ulcerogenesis. Pathophysiology 5, 155-166.
32. Nylander, O. & Pihl, L. 2006. Luminal hypotonicity increases duodenal mucosal permeability by a mechanism involving 5-hydroxytryptamine. Acta Physiol (Oxf) 186, 45-58.
33. Nylander, O. & Sjöblom, M. 2007. Modulation of mucosal permeability by vasoactive intestinal peptide or lidocain affects the adjustment of luminal hypotonicity in rat duodenum. Acta Physiol (Oxf) 189, 325-335.
34. Nylander, O., Kvietys, P. & Granger, D.N. 1989. Effects of hydrochloric acid on duodenal and jejunal mucosal permeability in the rat. Am J Physiol 257, G653-G660.
35. Nylander, O., Pihl, L. & Perry, M. 2003. Hypotonicity-induced increases in duodenal mucosal permeability facilitates adjustment of luminal osmolality. Am J Physiol Gastrointest Liver Physiol 285, G360-G370.
36. Padi, S.S., Jain, N.K., Singh, S. & Kulkarni, S.K. 2004. Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor. Eur J Pharmacol 491, 69-76.
37. Pihl, L. & Nylander, O. 2006. Products of cyclooxygenase-2 depress duodenal function in rats subjected to abdominal surgery. Acta Physiol (Oxf) 186, 279-290.
38. Powell, D.W. 1981. Barrier function of epithelia. Am J Physiol 241, G275-G288.
39. Schmid, H.R. & Ehrlein, H.J. 1993. Effects of enteral infusion of hypertonic saline and nutrients on canine jejunal motor patterns. Dig Dis Sci 38, 1062-1072.
40. Schwarz, N.T., Kalff, J.C., Turler, A., Engel, B.M., Watkins, S.C., Billiar, T.R. & Bauer, A.J. 2001. Prostanoid production via COX-2 as a causative mechanism of rodent postoperative ileus. Gastroenterology 121, 1354-1371.
41. Schwarz, N.T., Kalff, J.C., Turler, A., Speidel, N., Grandis, J.R., Billiar, T.R. & Bauer, A.J. 2004. Selective jejunal manipulation causes postoperative pan-enteric inflammation and dysmotility. Gastroenterology 126, 159-169.
42. Sigthorsson, G., Simpson, R.J., Walley, M., Anthony, A., Foster, R., Hotz-Behoftsitz, C., Palizban, A., Pombo, J., Watts, J., Morham, S.G. & Bjarnason, I. 2002. COX-1 and 2, intestinal integrity, and pathogenesis of nonsteroidal anti-inflammatory drug enteropathy in mice. Gastroenterology 122, 1913-1923.
43. Sjoblom, M., Jedstedt, G. & Flemstrom, G. 2001. Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion. J Clin Invest 108, 625-633.
44. Smulders, A.P., Tormey, J.D. & Wright, E.M. 1972. The effect of osmotically induced water flows on the permeability and ultrastructure of the rabbit gallbladder. J Membr Biol 7, 164-197.
45. Takeuchi, K., Kagawa, S., Mimaki, H., Aoi, M. & Kawauchi, S. 2002. COX and NOS isoforms involved in acid-induced duodenal bicarbonate secretion in rats. Dig Dis Sci 47, 2116-2124.
46. Tanaka, A., Hase, S., Miyazawa, T., Ohno, R. & Takeuchi, K. 2002. Role of cyclooxygenase (COX)-1 and COX-2 inhibition in nonsteroidal anti-inflammatory drug-induced intestinal damage in rats: relation to various pathogenic events. J Pharmacol Exp Ther 303, 1248-1254.
47. Thompson, D.G. & Wingate, D.L. 1988. Effects of osmoreceptor stimulation on human duodenal motor activity. Gut 29, 173-180.
48. Warner, T.D. & Mitchell, J.A. 2004. Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic. FASEB J 18, 790-804.
49. Winne, D. 1979. Rat jejunum perfused in situ: effect of perfusion rate and intraluminal radius on absorption rate and effective unstirred layer thickness. Naunyn Schmiedebergs Arch Pharmacol 307, 265-274.
50. Younoszai, M.K., Sapario, R.S. & Laughlin, M. 1978. Maturation of jejunum and ileum in rats. Water and electrolyte transport during in vivo perfusion of hypertonic solutions. J Clin Invest 62, 271-280.