Structural Insights into Genetic Variants of Na +/Glucose Cotransporter SGLT1 Causing Glucose-Galactose Malabsorption: VSGLT as a Model Structure

Cell Biochemistry and Biophysics

Volumn 63, Issue 2, 2012, Pages 151-158

  Raja, Mobeen ^a,b   Kinne, Rolf K H ^a  

^a MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Genetic variations; Glucose galactose malabsorption; Protein structure and function; SGLT1; Sodium glucose cotransporter

Indexed keywords

BACTERIAL PROTEIN; GALACTOSE; GLUCOSE; SLC5A1 PROTEIN, HUMAN; SODIUM GLUCOSE COTRANSPORTER 1;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; GENETIC VARIABILITY; GENETICS; HUMAN; HYDROGEN BOND; INTESTINE ABSORPTION; MALABSORPTION; METABOLISM; MISSENSE MUTATION; MOLECULAR GENETICS; PHYSIOLOGY; PROTEIN MOTIF; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; STRUCTURAL HOMOLOGY;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BACTERIAL PROTEINS; GALACTOSE; GENETIC VARIATION; GLUCOSE; HUMANS; HYDROGEN BONDING; INTESTINAL ABSORPTION; MALABSORPTION SYNDROMES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SODIUM-GLUCOSE TRANSPORTER 1; STRUCTURAL HOMOLOGY, PROTEIN;

BACTERIA (MICROORGANISMS); VIBRIO PARAHAEMOLYTICUS;

EID: 84861229144     PISSN: 10859195     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12013-012-9352-3     Document Type: Article

References (34)

1. +/sugar symport. Science, 321, 810-814.
2. Wright, E. M., & Turk, E. (2004). The sodium/glucose cotransport family SLC5. Pflügers Archiv, 447, 510-518.
3. Turk, E., & Wright, E. M. (1997). Membrane topology motifs in the SGLT cotransporter family. Journal of Membrane Biology, 159, 1-20.
4. Banerjee, S. K., McGaffin, K. R., Pastor-Soler, N. M., & Ahmad, F. (2009). SGLT1 is a novel cardiac glucose transporter that is perturbed in disease states. Cardiovascular Research, 84, 111-118.
5. +/glucose cotransporter (SGLT1) trafficking and function cause glucose-galactose malabsorption. Nature Genetics, 12, 216-220.
6. +-glucose cotransporters: SLC5. Physiology (Bethesda), 19, 370-376.
7. Taroni, C., Jones, S., & Thornton, J. M. (2000). Analysis and prediction of carbohydrate binding sites. Protein Engineering, 13, 89-98.
8. Abramson, J., Smirnova, I., Kasho, V., Verner, G., Kaback, H. R., & Iwata, S. (2003). Structure and mechanism of the lactose permease of Escherichia coli. Science, 301, 610-615.
9. Quiocho, F. A. (1989). Protein-Carbohydrate interactions-basic molecular-features. Pure and Applied Chemistry, 61, 1293-1306.
10. Wright, E. M., Loo, D. D., & Hirayama, B. A. (2011). Biology of human sodium glucose transporters. Physiological Reviews, 91, 733-794.
11. Wright, E. M., Turk, E., & Martin, M. G. (2002). Molecular basis for glucose-galactose malabsorption. Cell Biochemistry and Biophysics, 36, 115-121.
12. Magen, D., Sprecher, E., Zelikovic, I., & Skorecki, K. (2005). A novel missense mutation in SLC5A2 encoding SGLT2 underlies autosomal-recessive renal glucosuria and aminoaciduria. Kidney International, 67, 34-41.
13. Calado, J., Sznajer, Y., Metzger, D., Rita, A., Hogan, M. C., Kattamis, A., et al. (2008). Twenty-one additional cases of familial renal glucosuria: Absence of genetic heterogeneity, high prevalence of private mutations and further evidence of volume depletion. Nephrology, Dialysis, Transplantation, 23, 3874-3879.
14. Wright, E. M., Hirayama, B. A., & Loo, D. F. (2007). Active sugar transport in health and disease. Journal of Internal Medicine, 261, 32-43.
15. Lindquist, B., & Meeuwisse, G. W. (1962). Chronic diarrhoea caused by monosaccharide malabsorption. Acta Paediatrica, 51, 674-685.
16. Laplane, R., Polonovski, C., Lods, J. C., Debray, P., Etienne, M., & Pissarro, B. (1962). Lintolerance aux sucres a transfert intestinal actif-ses rapports avec lintolerance au lactose et le syndrome Coeliaque. Archives Francaises De Pediatrie, 19, 895.
17. Melin, K., & Meeuwisse, G. W. (1969). Glucose-galactose malabsorption. A genetic study. Acta Paediatrica Scandinavica, 188, 19-24.
18. Abramson, J., & Wright, E. M. (2009). Structure and function of Na(+)-symporters with inverted repeats. Current Opinion in Structural Biology, 19, 425-432.
19. +/glucose symporter (Sg1S) of Vibrio parahaemolyticus. Journal of Bacteriology, 179, 1805-1808.
20. Sujatha, M. S., & Balaji, P. V. (2004). Identification of common structural features of binding sites in galactose-specific proteins. Proteins, 55, 44-65.
21. +/Cl-dependent neurotransmitter transporters. Nature, 437, 215-223.
22. Raja, M. M., Tyagi, N. K., & Kinne, R. K. (2003). Phlorizin recognition in a C-terminal fragment of SGLT1 studied by tryptophan scanning and affinity labeling. The Journal of Biological Chemistry, 278, 49154-49163.
23. +/Glucose cotransporter. A bacterial member of the sodium/glucose transporter (SGLT) family. The Journal of Biological Chemistry, 275, 25959-25964.
24. Oulianova, N., Falk, S., & Berteloot, A. (2001). Two-step mechanism of phlorizin binding to the SGLT1 protein in the kidney. Journal of Membrane Biology, 179, 223-242.
25. Tyagi, N. K., Kumar, A., Goyal, P., Pandey, D., Siess, W., & Kinne, R. K. (2007). d-Glucose-recognition and phlorizin-binding sites in human sodium/d-glucose cotransporter 1 (hSGLT1): A tryptophan scanning study. Biochemistry, 46, 13616-13628.
26. +/glucose cotransporter gene SGLT1 in a patient with congenital glucose-galactose malabsorption: Normal trafficking but inactivation of the mutant protein. Biochimica Et Biophysica Acta-Molecular Basis of Disease, 1536, 141-147.
27. Monne, M., Nilsson, I., Johansson, M., Elmhed, N., & von Heijne, G. (1998). Positively and negatively charged residues have different effects on the position in the membrane of a model transmembrane helix. Journal of Molecular Biology, 284, 1177-1183.
28. Raja, M. (2011). The potassium channel KcsA: A model protein in studying membrane protein oligomerization and stability of oligomeric assembly? Archives of Biochemistry and Biophysics, 510, 1-10.
29. Ozdirekcan, S., Nyholm, T. K., Raja, M., Rijkers, D. T., Liskamp, R. M., & Killian, J. A. (2008). Influence of trifluoroethanol on membrane interfacial anchoring interactions of transmembrane alpha-helical peptides. Biophysical Journal, 94, 1315-1325.
30. +/glucose co-transporter. Nature, 330, 379-381.
31. Elsas, L. J. (1970). Glucose reabsorption in familial renal glycosuria and glucose-galactose malabsorption. Birth Defects Original Article Series, 6, 21-22.
32. Wright, E. M. (1998). Genetic disorders of membrane transport I. Glucose galactose malabsorption. American Journal of Physiology-Gastrointestinal and Liver Physiology, 275, G879-G882.
33. Diez-Sampedro, A., Wright, E. M., & Hirayama, B. A. (2001). Residue 457 controls sugar binding and transport in the Na(+)/glucose cotransporter. The Journal of Biological Chemistry, 276, 49188-49194.
34. +/glucose cotransporter and not an amino acid transporter. A reinterpretation. The Journal of Biological Chemistry, 269, 22488-22491.