Disorders of the optic nerve in mitochondrial cytopathies: New ideas on pathogenesis and therapeutic targets

Current Neurology and Neuroscience Reports

Volumn 12, Issue 3, 2012, Pages 308-317

  Sitarz, Kamil S ^a   Chinnery, Patrick F ^a   Yu Wai Man, Patrick ^a,b  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b ROYAL VICTORIA INFIRMARY   (United Kingdom)

Author keywords

Dominant optic atrophy; Haplogroup; Hereditary spastic paraplegia, Heteroplasmy; Idebenone; Leber hereditary optic neuropathy; Mitochondrial cytopathies; Mitochondrial DNA; Mitofusin; Multiple sclerosis; Neuroprotection; Optic nerve; Retinal ganglion cell

Indexed keywords

CYTOCHROME C; IDEBENONE; MITOCHONDRIAL DNA; MITOFUSIN 2; PLACEBO; PROTEIN; PROTEIN OPA1; PROTEIN TMEM126A; REACTIVE OXYGEN METABOLITE; UBIDECARENONE; UNCLASSIFIED DRUG;

ABSENCE OF SIDE EFFECTS; AUTOSOMAL DOMINANT OPTIC ATROPHY; BIOENERGY; CALCIUM HOMEOSTASIS; CELL LOSS; CLINICAL FEATURE; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SURVEILLANCE; DISEASE TRANSMISSION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; EXCITOTOXICITY; FRIEDREICH ATAXIA; GENE; GENE DELETION; GENE LOCUS; GENE THERAPY; GENETIC VARIABILITY; HEREDITARY MOTOR SENSORY NEUROPATHY; HEREDITARY MOTOR SENSORY NEUROPATHY TYPE 6; HEREDITARY MOTOR SENSORY NEUROPATHY TYPE 7; HETEROZYGOTE; HUMAN; LEBER HEREDITARY OPTIC NEUROPATHY; MFN2 GENE; MITOCHONDRIAL ENCEPHALOMYOPATHY; MITOCHONDRIAL RESPIRATION; NONHUMAN; OPA1 GENE; OPA3 GENE; OPTIC NERVE DISEASE; PATHOGENESIS; PHENOTYPIC VARIATION; PROPHYLAXIS; REHABILITATION; RETINA GANGLION CELL; REVIEW; TISSUE SPECIFICITY; TMEM126A GENE; VISUAL IMPAIRMENT; VISUAL REHABILITATION;

CALCIUM; HUMANS; MITOCHONDRIA; MITOCHONDRIAL DISEASES; OPTIC NERVE DISEASES; REACTIVE OXYGEN SPECIES;

EID: 84861227901     PISSN: 15284042     EISSN: 15346293     Source Type: Journal    
DOI: 10.1007/s11910-012-0260-0     Document Type: Review

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