Structural characterization of a novel degradant of the antifungal agent posaconazole

Journal of Pharmaceutical and Biomedical Analysis

Volumn 66, Issue , 2012, Pages 40-49

  Zhong, Wendy ^a   Yang, Xi ^b   Tong, Weidong ^a   Martin, Gary E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Merck Manufacturing Division   (United States)

Author keywords

1,1 ADEQUATE; Degradation product; HSQC 1,1 ADEQUATE; LC MS; NMR; Posaconazole

Indexed keywords

BENZODIAZEPINE DERIVATIVE; PIPERAZINE; POSACONAZOLE;

ACCURACY; ADEQUATE SPECTROSCOPY; ANTIFUNGAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DEGRADATION; DRUG DETERMINATION; DRUG ISOLATION; DRUG STRUCTURE; HETERONUCLEAR SINGLE QUANTUM COHERENCE; ION EXCHANGE; MASS SPECTROMETRY; MOLECULE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATIVE STRESS; PRIORITY JOURNAL; RING OPENING; SPECTROSCOPY; TANDEM MASS SPECTROMETRY;

ANTIFUNGAL AGENTS; BENZODIAZEPINES; CHROMATOGRAPHY, LIQUID; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PIPERAZINES; TANDEM MASS SPECTROMETRY; TRIAZOLES;

EID: 84861223150     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2012.02.023     Document Type: Article

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