Prostaglandin EP1 receptor down-regulates expression of cyclooxygenase-2 by facilitating its proteasomal degradation

Journal of Biological Chemistry

Volumn 287, Issue 21, 2012, Pages 17214-17223

  Haddad, Ariz ^a   Flint Ashtamker, Galit ^a   Minzel, Waleed ^a   Sood, Rapita ^a   Rimon, Gilad ^b   Barki Harrington, Liza ^a  

^a UNIVERSITY OF HAIFA   (Israel)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVITY RESULTS; COMPLEX FORMATIONS; CONCENTRATION-DEPENDENT; CYCLOOXYGENASE 2; DOWN-REGULATION; E3 LIGASE; G PROTEIN COUPLED RECEPTORS; PROSTAGLANDINE; PROTEASOMAL DEGRADATION; PROTEIN SYNTHESIS; RECEPTOR ACTIVATION; TUMORIGENESIS; UBIQUITINATION; UP-REGULATION;

CELL MEMBRANES; PATHOLOGY;

DEGRADATION;

CYCLOOXYGENASE 2; PROSTAGLANDIN E RECEPTOR 1; PROTEASOME; SCAFFOLD PROTEIN; UBIQUITIN PROTEIN LIGASE E3; PROSTAGLANDIN E; PTGER1 PROTEIN, HUMAN; PTGS2 PROTEIN, HUMAN; UBIQUITIN PROTEIN LIGASE;

ARTICLE; COMPLEX FORMATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ASSAY; ENZYME DEGRADATION; ENZYME LOCALIZATION; ENZYME REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; UBIQUITINATION; BIOSYNTHESIS; CELL STRAIN HEK293; DOSE RESPONSE; DOWN REGULATION; GENE EXPRESSION REGULATION; GENETICS; INFLAMMATION; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

CELL LINE, TUMOR; CYCLOOXYGENASE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEK293 CELLS; HUMANS; INFLAMMATION; PROSTAGLANDINS E; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; RECEPTORS, PROSTAGLANDIN E, EP1 SUBTYPE; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84861220041     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.304220     Document Type: Article

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