Trapping and structure determination of an intermediate in the allosteric transition of aspartate transcarbamoylase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 20, 2012, Pages 7741-7746

  Guo, Wenyue ^a   West, Jay M ^a   Dutton, Andrew S ^a   Tsuruta, Hiro ^b   Kantrowitz, Evan R ^a  

^a BOSTON COLLEGE   (United States)

^b SLAC NATIONAL ACCELERATOR LABORATORY   (United States)

Author keywords

Allostery; Cooperativity; Intermediate structure; Structural stabilization

Indexed keywords

ASPARTATE CARBAMOYLTRANSFERASE;

ALLOSTERISM; ARTICLE; CANONICAL ANALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME STRUCTURE; NONHUMAN; PH; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC REGULATION; ASPARTATE CARBAMOYLTRANSFERASE; CHROMATOGRAPHY, ION EXCHANGE; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HYDROGEN-ION CONCENTRATION; MODELS, MOLECULAR; PROTEIN CONFORMATION; SCATTERING, SMALL ANGLE;

EID: 84861216184     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1119683109     Document Type: Article

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