Monitoring the transition from the T to the R state in E. coli aspartate transcarbamoylase by X-ray crystallography: Crystal structures of the E50A mutant enzyme in four distinct allosteric states

Journal of Molecular Biology

Volumn 341, Issue 3, 2004, Pages 853-868

  Stieglitz, Kimberly ^a   Stec, Boguslaw ^b   Baker, Darren P ^a   Kantrowitz, Evan R ^a  

^a BOSTON COLLEGE   (United States)

^b UNIVERSITY OF TEXAS AT EL PASO   (United States)

Author keywords

allosteric transition; ATCase, aspartate transcarbamoylase; domain closure; PALA, N (phosphonacetyl) L aspartate; PAM, phosphonoacetamide; protein structure function; site specific mutagenesis; X ray crystallography

Indexed keywords

ASPARTATE CARBAMOYLTRANSFERASE; BACTERIAL ENZYME; MUTANT PROTEIN; SPARFOSIC ACID;

ALLOSTERISM; ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME MECHANISM; ENZYME MODIFICATION; ENZYME STRUCTURE; ESCHERICHIA COLI; NONHUMAN; PHYSICAL PHASE; PRIORITY JOURNAL; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ESCHERICHIA COLI;

EID: 4344612865     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2004.06.002     Document Type: Article

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