Transcriptional organization and physiological contributions of the relQ operon of Streptococcus mutans

Journal of Bacteriology

Volumn 194, Issue 8, 2012, Pages 1968-1978

  Kim, Jeong Nam ^a   Ahn, Sang Joon ^a   Seaton, Kinda ^a   Garrett, Steven ^a   Burne, Robert A ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NICOTINAMIDE ADENINE DINUCLEOTIDE KINASE; PHOSPHATE ACETYLTRANSFERASE; PSEUDOURIDINE SYNTHASE; SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; DENTAL CARIES; ENZYME INACTIVATION; GENE DELETION; GENE MUTATION; HOMEOSTASIS; NONHUMAN; NORTHERN BLOTTING; OPERON; OXIDATIVE STRESS; PRIORITY JOURNAL; RELQ OPERON; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STRAIN DIFFERENCE; STREPTOCOCCUS MUTANS; STRESS; TRANSCRIPTION REGULATION;

BACTERIAL PROTEINS; BIOFILMS; GENE DELETION; GENE EXPRESSION REGULATION, BACTERIAL; GENES, REPORTER; OPERON; PROMOTER REGIONS, GENETIC; STREPTOCOCCUS MUTANS; TIME FACTORS; TRANSCRIPTION, GENETIC;

STREPTOCOCCUS MUTANS;

EID: 84861215953     PISSN: 00219193     EISSN: 10985530     Source Type: Journal    
DOI: 10.1128/JB.00037-12     Document Type: Article

References (57)

1. Abranches J, et al. 2009. The molecular alarmone (p)ppGpp mediates stress responses, vancomycin tolerance, and virulence in Enterococcus faecalis. J. Bacteriol. 191:2248-2256.
2. Ahn SJ, Browngardt CM, Burne RA. 2009. Changes in biochemical and phenotypic properties of Streptococcus mutans during growth with aeration. Appl. Environ. Microbiol. 75:2517-2527.
3. Ahn SJ, Wen ZT, Burne RA. 2007. Effects of oxygen on virulence traits of Streptococcus mutans. J. Bacteriol. 189:8519-8527.
4. Ahn SJ, Wen ZT, Burne RA. 2006. Multilevel control of competence development and stress tolerance in Streptococcus mutans UA159. Infect. Immun. 74:1631-1642.
5. Ajdic D, et al. 2002. Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen. Proc. Natl. Acad. Sci. U. S. A. 99:14434-14439.
6. Banas JA. 2004. Virulence properties of Streptococcus mutans. Front. Biosci. 9:1267-1277.
7. Boyd DA, Cvitkovitch DG, Hamilton IR. 1995. Sequence, expression, and function of the gene for the nonphosphorylating, NADP-dependent glyceraldehyde-3-phosphate dehydrogenase of Streptococcus mutans. J. Bacteriol. 177:2622-2627.
8. Brown AT, Wittenberger CL. 1972. Fructose-1,6-diphosphatedependent lactate dehydrogenase from a cariogenic streptococcus: purification and regulatory properties. J. Bacteriol. 110:604-615.
9. Burne RA, Chen YY, Wexler DL, Kuramitsu H, Bowen WH. 1996. Cariogenicity of Streptococcus mutans strains with defects in fructan metabolism assessed in a program-fed specific-pathogen-free rat model. J. Dent. Res. 75:1572-1577.
10. Carlsson J, Kujala U, Edlund MB. 1985. Pyruvate dehydrogenase activity in Streptococcus mutans. Infect. Immun. 49:674-678.
11. Cashel M, Gentry DR, Hernandez VJ, Vinella D. 1996. The stringent response, p 1458-1496. In R. C. I. F. C. Neidhardt, J. L. Ingraham, E. C. C. Lin, K. B. Low, B. Magasanik, W. Reznikoff, M. Riley, M. Shaechter, A. E. Umbarger (ed), Escherichia coli and Salmonella: cellular and molecular biology, 2nd ed ASM Press, Washington, DC.
12. Chang DE, Shin S, Rhee JS, Pan JG. 1999. Acetate metabolism in a pta mutant of Escherichia coli W3110: importance of maintaining acetyl coenzyme A flux for growth and survival. J. Bacteriol. 181:6656-6663.
13. Del Campo M, Kaya Y, Ofengand J. 2001. Identification and site of action of the remaining four putative pseudouridine synthases in Escherichia coli. RNA. 7:1603-1615.
14. Garavaglia S, Galizzi A, Rizzi M. 2003. Allosteric regulation of Bacillus subtilis NAD kinase by quinolinic acid. J. Bacteriol. 185:4844-4850.
15. Grose JH, Joss L, Velick SF, Roth JR. 2006. Evidence that feedback inhibition of NAD kinase controls responses to oxidative stress. Proc. Natl. Acad. Sci. U. S. A. 103:7601-7606.
16. Grundy FJ, Waters DA, Allen SH, Henkin TM. 1993. Regulation of the Bacillus subtilis acetate kinase gene by CcpA. J. Bacteriol. 175:7348-7355.
17. Gupta S, Clark DP. 1989. Escherichia coli derivatives lacking both alcohol dehydrogenase and phosphotransacetylase grow anaerobically by lactate fermentation. J. Bacteriol. 171:3650-3655.
18. 2O-forming oxidase induced in Streptococcus mutans. J. Gen. Microbiol. 139:2343-2351.
19. Higuchi M, et al. 1999. Functions of two types of NADH oxidases in energy metabolism and oxidative stress of Streptococcus mutans. J. Bacteriol. 181:5940-5947.
20. Hogg T, Mechold U, Malke H, Cashel M, Hilgenfeld R. 2004. Conformational antagonism between opposing active sites in a bifunctional RelA/SpoT homolog modulates (p)ppGpp metabolism during the stringent response [corrected]. Cell 117:57-68.
21. Kari C, Torok I, Travers A. 1977. ppGpp cycle in Escherichia coli. Mol. Gen. Genet. 150:249-255.
22. Klein AH, Shulla A, Reimann SA, Keating DH, Wolfe AJ. 2007. The intracellular concentration of acetyl phosphate in Escherichia coli is sufficient for direct phosphorylation of two-component response regulators. J. Bacteriol. 189:5574-5581.
23. Kodama T, et al. 1987. Effects of oxygen on glucose-limited growth of Streptococcus mutans. Infect. Immun. 55:169-173.
24. Kolenbrander PE, et al. 2006. Bacterial interactions and successions during plaque development. Periodontol. 2000 42:47-79.
25. Kremer BH, et al. 2001. Characterization of the sat operon in Streptococcus mutans: evidence for a role of Ffh in acid tolerance. J. Bacteriol. 183: 2543-2552.
26. Lemos JA, Abranches J, Burne RA. 2005. Responses of cariogenic streptococci to environmental stresses. Curr. Issues Mol. Biol. 7:95-107.
27. Lemos JA, Brown TA, Jr, Burne RA. 2004. Effects of RelA on key virulence properties of planktonic and biofilm populations of Streptococcus mutans. Infect. Immun. 72:1431-1440.
28. Lemos JA, Burne RA. 2008. A model of efficiency: stress tolerance by Streptococcus mutans. Microbiology 154:3247-3255.
29. Lemos JA, Chen YY, Burne RA. 2001. Genetic and physiologic analysis of the groE operon and role of the HrcA repressor in stress gene regulation and acid tolerance in Streptococcus mutans. J. Bacteriol. 183:6074-6084.
30. Lemos JA, Lin VK, Nascimento MM, Abranches J, Burne RA. 2007. Three gene products govern (p)ppGpp production by Streptococcus mutans. Mol. Microbiol. 65:1568-1581.
31. Magnusson LU, Farewell A, Nystrom T. 2005. ppGpp: a global regulator in Escherichia coli. Trends Microbiol. 13:236-242.
32. Magnusson LU, Gummesson B, Joksimovic P, Farewell A, Nystrom T. 2007. Identical, independent, and opposing roles of ppGpp and DksA in Escherichia coli. J. Bacteriol. 189:5193-5202.
33. Marquis RE. 1995. Oxygen metabolism, oxidative stress and acid-base physiology of dental plaque biofilms. J. Ind. Microbiol. 15:198-207.
34. McCleary WR, Stock JB. 1994. Acetyl phosphate and the activation of two-component response regulators. J. Biol. Chem. 269:31567-31572.
35. McCleary WR, Stock JB, Ninfa AJ. 1993. Is acetyl phosphate a global signal in Escherichia coli? J. Bacteriol. 175:2793-2798.
36. Mechold U, Cashel M, Steiner K, Gentry D, Malke H. 1996. Functional analysis of a relA/spoT gene homolog from Streptococcus equisimilis. J. Bacteriol. 178:1401-1411.
37. Seq, the Rel/Spo enzyme from Streptococcus equisimilis. J. Bacteriol. 184:2878-2888.
38. Nanamiya H, et al. 2008. Identification and functional analysis of novel (p)ppGpp synthetase genes in Bacillus subtilis. Mol. Microbiol. 67:291-304.
39. Nascimento MM, Lemos JA, Abranches J, Lin VK, Burne RA. 2008. Role of RelA of Streptococcus mutans in global control of gene expression. J. Bacteriol. 190:28-36.
40. Nguyen D, et al. 2011. Active starvation responses mediate antibiotic tolerance in biofilms and nutrient-limited bacteria. Science 334:982-986.
41. Ofengand J, Campo MD. 2004. Chapter 4.6.1, Modified nucleosides in Escherichia coli ribosomal RNA. In Curtiss R, III, et al (ed), EcoSal-Escherichia coli and Salmonella: cellular and molecular biology. ASM Press, Washington, DC.
42. Ofengand J, Del Campo M, Kaya Y. 2001. Mapping pseudouridines in RNA molecules. Methods 25:365-373.
43. Potrykus K, Cashel M. 2008. (p)ppGpp: still magical? Annu. Rev. Microbiol. 62:35-51.
44. Ramos-Montañez S, Kazmierczak KM, Hentchel KL, Winkler ME. 2010. Instability of ackA (acetate kinase) mutations and their effects on acetyl phosphate and ATP amounts in Streptococcus pneumoniae D39. J. Bacteriol. 192:6390-6400.
45. Raychaudhuri S, Conrad J, Hall BG, Ofengand J. 1998. A pseudouridine synthase required for the formation of two universally conserved pseudouridines in ribosomal RNA is essential for normal growth of Escherichia coli RNA. 4:1407-1417.
46. Seaton K, Ahn SJ, Sagstetter AM, Burne RA. 2011. A transcriptional regulator and ABC transporters link stress tolerance, (p)ppGpp, and genetic competence in Streptococcus mutans. J. Bacteriol. 193:862-874.
47. Senadheera MD, et al. 2007. The Streptococcus mutans vicX gene product modulates gtfB/C expression, biofilm formation, genetic competence, and oxidative stress tolerance. J. Bacteriol. 189:1451-1458.
48. Shubeita HE, Sambrook JF, McCormick AM. 1987. Molecular cloning and analysis of functional cDNA and genomic clones encoding bovine cellular retinoic acid-binding protein. Proc. Natl. Acad. Sci. U. S. A. 84: 5645-5649.
49. Speckman RA, Collins EB. 1973. Incorporation of radioactive acetate into diacetyl by Streptococcus diacetilactis. Appl. Microbiol. 26:744-746.
50. Takahashi S, Abbe K, Yamada T. 1982. Purification of pyruvate formatelyase from Streptococcus mutans and its regulatory properties. J. Bacteriol. 149:1034-1040.
51. Terleckyj B, Willett NP, Shockman GD. 1975. Growth of several cariogenic strains of oral streptococci in a chemically defined medium. Infect. Immun. 11:649-655.
52. Wanner BL. 1993. Gene regulation by phosphate in enteric bacteria. J. Cell. Biochem. 51:47-54.
53. Wen ZT, Burne RA. 2004. LuxS-mediated signaling in Streptococcus mutans is involved in regulation of acid and oxidative stress tolerance and biofilm formation. J. Bacteriol. 186:2682-2691.
54. Wolfe AJ. 2005. The acetate switch. Microbiol. Mol. Biol. Rev. 69:12-50.
55. Wolfe AJ, et al. 2003. Evidence that acetyl phosphate functions as a global signal during biofilm development. Mol. Microbiol. 48:977-988.
56. Wu J, Xie J. 2009. Magic spot: (p) ppGpp. J. Cell. Physiol. 220:297-302.
57. Zeng L, Wen ZT, Burne RA. 2006. A novel signal transduction system and feedback loop regulate fructan hydrolase gene expression in Streptococcus mutans. Mol. Microbiol. 62:187-200.