APhL antibody ELISA as an alternative to anticardiolipin test for the diagnosis of antiphospholipid syndrome

International Journal of Clinical and Experimental Pathology

Volumn 5, Issue 3, 2012, Pages 210-215

  Suh Lailam, Brenda B ^a   Cromar, Anndorie ^a   Davis, K Wayne ^a   Tebo, Anne E ^a,b  

^a ARUP INSTITUTE FOR CLINICAL AND EXPERIMENTAL PATHOLOGY   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Anticardiolipin; Antiphospholipid antibodies; APhl; Method comparison

Indexed keywords

BETA2 GLYCOPROTEIN 1; BIOLOGICAL MARKER; CARDIOLIPIN ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LUPUS ANTICOAGULANT; PHOSPHOLIPID ANTIBODY;

ADOLESCENT; ADULT; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; BLOOD; CASE CONTROL STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EVALUATION; FEMALE; HUMAN; IMMUNOLOGY; LABORATORY DIAGNOSIS; MALE; MIDDLE AGED; PREDICTIVE VALUE; SENSITIVITY AND SPECIFICITY;

ADOLESCENT; ADULT; ANTIBODIES, ANTICARDIOLIPIN; ANTIBODIES, ANTIPHOSPHOLIPID; ANTIPHOSPHOLIPID SYNDROME; BETA 2-GLYCOPROTEIN I; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FALSE POSITIVE REACTIONS; FEMALE; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LUPUS COAGULATION INHIBITOR; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; SENSITIVITY AND SPECIFICITY; YOUNG ADULT;

EID: 84861214687     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, Derksen RH, PG DEG, Koike T, Meroni PL, Reber G, Shoenfeld Y, Tincani A, Vlachoyiannopoulos PG and Krilis SA. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006; 4: 295-306.
2. Pierangeli SS, de Groot PG, Dlott J, Favaloro E, Harris EN, Lakos G, Ortel T, Meroni PL, Otomo K, Pengo V, Tincani A, Wong R and Roubey R. 'Criteria' aPL tests: report of a task force and preconference workshop at the 13th International Congress on Antiphospholipid Antibodies, Galveston, Texas, April 2010. Lupus 2011; 20: 182-190.
3. Tincani A, Allegri F, Sanmarco M, Cinquini M, Taglietti M, Balestrieri G, Koike T, Ichikawa K, Meroni P and Boffa MC. Anticardiolipin antibody assay: a methodological analysis for a better consensus in routine determinations-a cooperative project of the European Antiphospholipid Forum. Thromb Haemost 2001; 86: 575-583.
4. Galli M, Luciani D, Bertolini G and Barbui T. Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: a systematic review of the literature. Blood 2003; 101: 1827-1832.
5. Ruffatti A, Tonello M, Del Ross T, Cavazzana A, Grava C, Noventa F, Tona F, Iliceto S and Pengo V. Antibody profile and clinical course in primary antiphospholipid syndrome with pregnancy morbidity. Thromb Haemost 2006; 96: 337-341.
6. Opatrny L, David M, Kahn SR, Shrier I and Rey E. Association between antiphospholipid antibodies and recurrent fetal loss in women without autoimmune disease: a metaanalysis. J Rheumatol 2006; 33: 2214-2221.
7. Giannakopoulos B, Passam F, Ioannou Y and Krilis SA. How we diagnose the antiphospholipid syndrome. Blood 2009; 113: 985-994.
8. Erkan D, Barbhaiya M, George D, Sammaritano L and Lockshin M. Moderate versus high-titer persistently anticardiolipin antibody positive patients: are they clinically different and does hightiter anti-beta 2-glycoprotein-I antibody positivity offer additional predictive information? Lupus 2010; 19: 613-619.
9. Agopian MS, Boctor FN and Peter JB. Falsepositive test result for IgM anticardiolipin antibody due to IgM rheumatoid factor. Arthritis Rheum 1988; 31: 1212-1213.
10. Leroy V, Arvieux J, Jacob MC, Maynard-Muet M, Baud M and Zarski JP. Prevalence and significance of anticardiolipin, anti-beta2 glycoprotein I and anti-prothrombin antibodies in chronic hepatitis C. Br J Haematol 1998; 101: 468-474.
11. Galperin I, Fortin PR, Subang R, Newkirk MM and Rauch J. A subset of rheumatoid factors crossreacts with cardiolipin in patients positive for IgM rheumatoid factor and anticardiolipin antibodies. J Rheumatol 2000; 27: 820-821.
12. Santiago M, Martinelli R, Ko A, Reis EA, Fontes RD, Nascimento EG, Pierangeli S, Espinola R and Gharavi A. Anti-beta2 glycoprotein I and anticardiolipin antibodies in leptospirosis, syphilis and Kala-azar. Clin Exp Rheumatol 2001; 19: 425-430.
13. Zachou K, Liaskos C, Christodoulou DK, Kardasi M, Papadamou G, Gatselis N, Georgiadou SP, Tsianos EV and Dalekos GN. Anti-cardiolipin antibodies in patients with chronic viral hepatitis are independent of beta2-glycoprotein I cofactor or features of antiphospholipid syndrome. Eur J Clin Invest 2003; 33: 161-168.
14. Pengo V, Biasiolo A, Bison E, Chantarangkul V and Tripodi A. Antiphospholipid antibody ELISAs: survey on the performance of clinical laboratories assessed by using lyophilized affinitypurified IgG with anticardiolipin and anti-beta2-Glycoprotein I activity. Thromb Res 2007; 120: 127-133.
15. Lakos G, Teodorescu M. IgM, but not IgA rheumatoid factor interferes with anti-cardiolipin and antibeta2 glycoprotein I measurements: a quantitative analysis. Lupus 2011; 20: 614-619.
16. Von Landenberg P, Lehmann HW, Knoll A, Dorsch S and Modrow S. Antiphospholipid antibodies in pediatric and adult patients with rheumatic disease are associated with parvovirus B19 infection. Arthritis Rheum 2003; 48: 1939-1947.
17. de Groot PG, Derksen RH and de Laat B. Twentytwo years of failure to set up undisputed assays to detect patients with the antiphospholipid syndrome. Semin Thromb Hemost 2008; 34: 347-355.
18. Galli M, Reber G, de Moerloose P and de Groot PG. Invitation to a debate on the serological criteria that define the antiphospholipid syndrome. J Thromb Haemost 2008; 6: 399-401.
19. Merkel PA, Chang Y, Pierangeli SS, Harris EN and Polisson RP. Comparison between the standard anticardiolipin antibody test and a new phospholipid test in patients with connective tissue diseases. J Rheumatol 1999; 26: 591-596.
20. Atsumi T, Ieko M, Bertolaccini ML, Ichikawa K, Tsutsumi A, Matsuura E and Koike T. Association of autoantibodies against the phosphatidylserine -prothrombin complex with manifestations of the antiphospholipid syndrome and with the presence of lupus anticoagulant. Arthritis Rheum 2000; 43: 1982-1993.
21. de Laat B, Pengo V, Pabinger I, Musial J, Voskuyl AE, Bultink IE, Ruffatti A, Rozman B, Kveder T, de Moerloose P, Boehlen F, Rand J, Ulcova-Gallova Z, Mertens K and de Groot PG. The association between circulating antibodies against domain I of beta2-glycoprotein I and thrombosis: an international multicenter study. J Thromb Haemost 2009; 7: 1767-1773.
22. Atsumi T, Koike T. Antiprothrombin antibody: why do we need more assays? Lupus 2010; 19: 436-439.
23. Ruffatti A, Olivieri S, Tonello M, Bortolati M, Bison E, Salvan E, Facchinetti M and Pengo V. Influence of different IgG anticardiolipin antibody cut-off values on antiphospholipid syndrome classification. J Thromb Haemost 2008; 6: 1693-1696.
24. Nash MJ, Camilleri RS, Kunka S, Mackie IJ, Machin SJ and Cohen H. The anticardiolipin assay is required for sensitive screening for antiphospholipid antibodies. J Thromb Haemost 2004; 2: 1077-1081.