Moderate versus high-titer persistently anticardiolipin antibody positive patients: Are they clinically different and does high-titer anti- β2-glycoprotein-I antibody positivity offer additional predictive information?

Lupus

Volumn 19, Issue 5, 2010, Pages 613-619

  Erkan, D ^a,b   Barbhaiya, M ^b   George, D ^c   Sammaritano, L ^a,b   Lockshin, Md ^a,b  

^a HOSPITAL FOR SPECIAL SURGERY   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Anti 2 glycoprotein I antibodies; Anticardiolipin antibodies; Antiphospholipid antibodies; Antiphospholipid syndrome

Indexed keywords

ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; BETA2 GLYCOPROTEIN 1 ANTIBODY; CARDIOLIPIN ANTIBODY; HYDROXYCHLOROQUINE; LUPUS ANTICOAGULANT; PHOSPHOLIPID ANTIBODY;

ANTIBODY TITER; ANTIPHOSPHOLIPID SYNDROME; ARTERY THROMBOSIS; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; HUMAN; HUMAN TISSUE; IMMUNOASSAY; LIVEDO RETICULARIS; MAJOR CLINICAL STUDY; NUCLEAR MAGNETIC RESONANCE IMAGING; PREDICTION; PREGNANCY DISORDER; PRIORITY JOURNAL; RISK FACTOR; THROMBOCYTOPENIA; VALVULAR HEART DISEASE; VEIN THROMBOSIS; WHITE MATTER;

AGED; ANTIBODIES, ANTICARDIOLIPIN; ANTIPHOSPHOLIPID SYNDROME; AUTOANTIBODIES; BETA 2-GLYCOPROTEIN I; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; MALE; PREDICTIVE VALUE OF TESTS;

EID: 77951240113     PISSN: 09612033     EISSN: None     Source Type: Journal    
DOI: 10.1177/0961203309355300     Document Type: Article

References (16)

1. Miyakis S., Lockshin MD, Atsumi T., et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome. J Thromb Haemost 2006 ; 4: 295-306.
2. Galli M., Reber G., De Moerloose P., De Groot PG Invitation to a debate on the serological criteria that define the antiphospholipid syndrome. J Thromb Haemost 2008 ; 6: 399-401.
3. Galli M., Luciani D., Bertolini G., Barbui T. Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: a systematic review of the literature. Blood 2003 ; 101: 1827-1832. (Pubitemid 36237580)
4. Varley M., Varley L., Erkan D., et al. Lupus anticoagulant positivity is associated with higher titers of anticardiolipin and anti-β2-glycoprotein-I antibodies. Arthritis Rheum 2005 ; 52: 4103 (abstract).
5. Galli M., Borrelli G., Jacobsen EM, et al. Clinical Significance of different antiphospholipid antibodies in the WAPS (warfarin in the antiphospholipid syndrome) study. Blood 2007 ; 110: 1178-1183. (Pubitemid 47281414)
6. Levine SR, Salowich-Palm L., Sawaya KL, et al. IgG anticardiolipin antibody titer > 40 GPL and the risk of subsequent thrombo-occlusive events and death. A prospective cohort study. Stroke 1997 ; 28: 1660-1665. (Pubitemid 27391430)
7. Lockshin MD, Druzin ML, Qamar T. Prednisone does not prevent recurrent fetal death in women with antiphospholipid antibody. Am J Obstet Gynecol 1989 ; 160: 439-443. (Pubitemid 19065395)
8. Galli M. Antiphospholipid antibodies and thrombosis: do test patterns identify the patients risk? Thromb Res 2004 ; 114: 597-601. (Pubitemid 39422597)
9. Rufatti A., Del Ross T., Ciprian M., et al. Risk factors for a first thrombotic event in antiphospholipid antibody carriers: A multicentre, retrospective follow-up study. Ann Rheum Dis 2009 ; 68: 397-399.
10. Erkan D., Derksen WJ, Kaplan V., et al. Real world experience with antiphospholipid antibody tests: how stable are results over time? Ann Rheum Dis 2005 ; 64: 1321-1325. (Pubitemid 41206250)
11. Lee EY, Lee CK, Lee TH, et al. Does the anti-beta2-glycoprotein I antibody provide additional information in patients with thrombosis? Thromb Res 2003 ; 111: 29-32. (Pubitemid 37485922)
12. Kaplan V., Erkan D., Sammaritano L., Pierangeli SS, Roubey R., Lockshin MD Real world experience with antiphospholipid antibodies: the significance of double versus triple aPL positivity. Arthritis Rheum 2005 ; 52: S593 - S594 (abstract).
13. Chapman J., Cohen-Armon M., Shoenfeld Y., Korczyn AD Antiphospholipid antibodies permeabilize and depolarize brain synaptoneurosomes. Lupus 1999 ; 8: 127-133. (Pubitemid 29103599)
14. Kozora E., Hanly JG, Lapteva L., Filley CM Cognitive dysfunction in systemic lupus erythematosus: past, present, and future. Arthritis Rheum 2008 ; 58: 3286-3298.
15. Kozora E., Archiniegas DB, Filley CM, et al. Cognitive and neurologic status in patients with systemic lupus erythematosus without major neuropsychiatric syndromes. Arthritis Rheum 2008 ; 59: 1639-1646.
16. Tenedios F., Erkan D., Lockshin MD Cardiac involvement in the antiphospholipid syndrome. Lupus 2005 ; 14: 691-696. (Pubitemid 41413293)