Multisite phosphorylation disrupts arginine-glutamate salt bridge networks required for binding of cytoplasmic linker-associated protein 2 (CLASP2) to end-binding protein 1 (EB1)

Journal of Biological Chemistry

Volumn 287, Issue 21, 2012, Pages 17050-17064

  Kumar, Praveen ^a   Chimenti, Michael S ^a   Pemble, Hayley ^a   Schönichen, André ^a   Thompson, Oliver ^a   Jacobson, Matthew P ^a   Wittmann, Torsten ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

31P-NMR SPECTROSCOPY; ARGININE RESIDUE; BINDING FREE ENERGY; BINDING MOTIF; C-TERMINAL TAIL; CYCLIN-DEPENDENT KINASE; DISORDERED REGIONS; DIVERSE PROTEINS; GLYCOGEN SYNTHASE KINASE-3; HYDROGEN BOND NETWORKS; IN-VITRO; INTRACELLULAR STRUCTURES; INTRAMOLECULAR INTERACTIONS; MICROTUBULE DYNAMICS; MICROTUBULES; MOLECULAR DYNAMICS SIMULATIONS; MULTI-SITE; SALT BRIDGES;

ARGININE; BINDING ENERGY; ELECTROSTATICS; ENZYME ACTIVITY; HYDROGEN; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHORYLATION; PROTEINS;

BINDING SITES;

ARGININE; BINDING PROTEIN; CYTOPLASMIC LINKER ASSOCIATED PROTEIN 2; END BINDING PROTEIN 1; GLUTAMIC ACID; GLYCOGEN SYNTHASE KINASE 3; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; HYDROGEN BOND; MOLECULAR DYNAMICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; STRUCTURE ANALYSIS;

AMINO ACID MOTIFS; GLYCOGEN SYNTHASE KINASE 3; HELA CELLS; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; MICROTUBULES; MITOSIS; MOLECULAR DYNAMICS SIMULATION; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; STATIC ELECTRICITY;

VERTEBRATA;

EID: 84861210634     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.316661     Document Type: Article

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