Improvement of benzylisoquinoline alkaloid productivity by overexpression of 3′-hydroxy-N-methylcoclaurine 4′-O-methyltransferase in transgenic Coptis japonica plants

Biological and Pharmaceutical Bulletin

Volumn 35, Issue 5, 2012, Pages 650-659

  Inui, Takayuki ^a   Kawano, Noriaki ^a   Shitan, Nobukazu ^b   Yazaki, Kazufumi ^c   Kiuchi, Fumiyuki ^a,e   Kawahara, Nobuo ^a   Sato, Fumihiko ^d   Yoshimatsu, Kayo ^a  

^a NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION   (Japan)

^b KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d KYOTO UNIVERSITY   (Japan)

^e KEIO UNIVERSITY   (Japan)

Author keywords

3 hydroxy N methylcoclaurine 4 O methyltransferase; Benzylisoquinoline alkaloid; Berberine; Coptis japonica; Metabolic engineering; Transgenic plant

Indexed keywords

3' HYDROXY N METHYLCOCLAURINE 4' O METHYLTRANSFERASE; BERBERINE; BISBENZYLISOQUINOLINE ALKALOID; METHYLTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIUM TRANSFORMATION; CONTROLLED STUDY; COPTIS JAPONICA; DNA MODIFICATION; ENZYME ACTIVITY; ENZYME SYNTHESIS; GENE OVEREXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLIC ENGINEERING; NONHUMAN; NUCLEOTIDE SEQUENCE; PLANT CELL CULTURE; PLANT GENE; PLANT LEAF; PLANT ROOT; REAL TIME POLYMERASE CHAIN REACTION; RHIZOME; TRANSGENIC PLANT;

AGROBACTERIUM; BERBERINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COPTIS; GENE EXPRESSION; GENES, PLANT; GENETIC ENGINEERING; PLANT PROTEINS; PLANT STRUCTURES; POLYMERASE CHAIN REACTION; PROTEIN O-METHYLTRANSFERASE; TRANSFORMATION, GENETIC;

EID: 84861210181     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.35.650     Document Type: Article

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