Leukotoxin (Leukothera®) targets active Leukocyte Function Antigen-1 (LFA-1) protein and triggers a lysosomal mediated cell death pathway

Journal of Biological Chemistry

Volumn 287, Issue 21, 2012, Pages 17618-17627

  DiFranco, Kristina M ^a   Gupta, Anukriti ^a   Galusha, Lindsey E ^a   Perez, Jarelys ^a   Nguyen, To Vy K ^a   Fineza, Camille D ^a   Kachlany, Scott C ^a,b  

^a RUTGERS SCHOOL OF DENTAL MEDICINE   (United States)

^b Actinobac Biomed Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; CASPASES; CELL-DEATH PATHWAYS; CYTOSOLS; INTEGRINS; LYSOSOMAL MEMBRANES; ORAL BACTERIA; PROTEIN TOXINS; RAPID ACTIVATION; THERAPEUTIC AGENTS; VESICULAR TRAFFICKING; WHITE BLOOD CELLS;

ANTIGENS;

CELL DEATH;

BETA INTEGRIN; CASPASE; CATHEPSIN D; LEUKOTHERA; LEUKOTOXIN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; UNCLASSIFIED DRUG;

AGGREGATIBACTER ACTINOMYCETEMCOMITANS; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; BINDING AFFINITY; CELL DEATH; CELL MEDIATED CYTOTOXICITY; CONTROLLED STUDY; CYTOSOL; CYTOTOXIC T LYMPHOCYTE; DRUG MECHANISM; DRUG PROTEIN BINDING; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME RELEASE; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; INTERNALIZATION; LYMPHOCYTE MIGRATION; LYSOSOME MEMBRANE; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FUNCTION;

CASPASES; CELL DEATH; CELL LINE; ENZYME ACTIVATION; EXOTOXINS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTRACELLULAR MEMBRANES; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; LYSOSOMES; MONOCYTES;

BACTERIA (MICROORGANISMS);

EID: 84861204678     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.314674     Document Type: Article

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