Conserved asparagine residue located in binding pocket controls cation selectivity and substrate interactions in neuronal glutamate transporter

Journal of Biological Chemistry

Volumn 287, Issue 21, 2012, Pages 17198-17205

  Teichman, Shlomit ^a   Qu, Shaogang ^a,b   Kanner, Baruch I ^a  

^a HEBREW UNIVERSITY   (Israel)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE RESIDUE; BINDING POCKETS; CATION SELECTIVITY; COUNTERTRANSPORT; D-ASPARTATE; GLUTAMATE TRANSPORTERS; GLUTAMIC ACID; L-GLUTAMATE; STRUCTURAL WORKS; SUBSTRATE BINDING; SUBSTRATE INTERACTION; SYNAPTIC CLEFT; THREONINE RESIDUES; TRANSPORT MECHANISM; WILD TYPES;

AMINO ACIDS; LITHIUM; POSITIVE IONS;

SUBSTRATES;

ASPARAGINE; ASPARTIC ACID; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; SERINE; SODIUM ION; THREONINE;

AMINO ACID SUBSTITUTION; AMINO ACID TRANSPORT; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME SPECIFICITY; FEMALE; ION CONDUCTANCE; MUTATIONAL ANALYSIS; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RESIDUE ANALYSIS; UPREGULATION;

AMINO ACID SUBSTITUTION; ANIMALS; ASPARAGINE; BINDING SITES; EXCITATORY AMINO ACID TRANSPORTER 3; ION TRANSPORT; MUTATION, MISSENSE; RABBITS; SUBSTRATE SPECIFICITY; XENOPUS LAEVIS;

EID: 84861204243     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.355040     Document Type: Article

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