A novel function of NOC2 in agonist-induced intracellular ca2+ increase during zymogen-granule exocytosis in pancreatic acinar cells

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Ogata, Sho ^a,b,c   Miki, Takashi ^d,e   Seino, Susumu ^d   Tamai, Seiichi ^b   Kasai, Haruo ^a,f   Nemoto, Tomomi ^a,g  

^a GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

^b NATIONAL DEFENSE MEDICAL COLLEGE HOSPITAL   (Japan)

^c NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^d KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e CHIBA UNIVERSITY   (Japan)

^f UNIVERSITY OF TOKYO   (Japan)

^g HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; BINDING PROTEIN; CALCIUM ION; CHOLECYSTOKININ; NOC2 PROTEIN; UNCLASSIFIED DRUG;

ACINAR CELL; ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; EXOCYTOSIS; KNOCKOUT MOUSE; MEMBRANE FUSION; MOUSE; NONHUMAN; PHOTOLYSIS; PROTEIN FUNCTION; WILD TYPE;

ACINAR CELLS; ANIMALS; CALCIUM; CALCIUM SIGNALING; EXOCYTOSIS; MEMBRANE FUSION; MICE; MICE, KNOCKOUT; PANCREAS; PANCREAS, EXOCRINE; PROTEINS; SECRETORY VESICLES;

MUS;

EID: 84861204206     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0037048     Document Type: Article

References (37)

1. Takai Y, Sasaki T, Matozaki T, (2001) Small GTP-binding protein. Physiol Rev 81: 152-208.
2. Williams JA, Chen X, Sabbatini ME, (2009) Small G proteins as key regulators of pancreatic digestive enzyme secretion. Am J Physiol Endocrinol Metab 296: E405-414.
3. Zerial M, McBride H, (2001) Rab proteins as membrane organizers. Nat Rev Mol Cell Biol 2: 107-117.
4. Burgoyne RD, Morgan A, (2003) Secretory granule exocytosis. Physiol Rev 83: 581-632.
5. Jahn R, (2004) Principles of exocytosis and membrane fusion. Ann N Y Acad Sci 1014: 170-178.
6. Castillo PE, Janz R, Sudhof TC, Tzounopoulos T, Malenka RC, et al. (1997) Rab3A is essential for mossy fibre long-term potentiation in the hippocampus. Nature 388: 590-593.
7. Fischer von Mollard G, Stahl B, Khokhlatchev A, Sudhof T C, Jahn R, (1994) Rab3C is a synaptic vesicle protein that dissociates from synaptic vesicles after stimulation of exocytosis. J Biol Chem 269: 10971-10974.
8. Ohnishi H, Samuelson LC, Yule DI, Ernst SA, Williams JA, (1997) Overexpression of Rab3D enhances regulated amylase secretion from pancreatic acini of transgenic mice. J Clin Invest 100: 3044-3052.
9. Chen X, Edwards JA, Logsdon CD, Ernst SA, Williams JA, (2002) Dominant negative Rab3D inhibits amylase release from mouse pancreatic acini. J Biol Chem 277: 18002-18009.
10. Schluter OM, Schmitz F, Jahn R, Rosenmund C, Sudhof TC, (2004) A complete genetic analysis of neuronal Rab3 function. J Neurosci 24: 6629-6637.
11. Kotake K, Ozaki N, Mizuta M, Sekiya S, Inagaki N, Seino S, (1997) Noc2, a putative zinc finger protein involved in exocytosis in endocrine cells. J Biol Chem 272: 29407-29410.
12. Cheviet S, Waselle L, Regazzi R, (2004) Noc-king out exocrine and endocrine secretion. Trends Cell Biol 14: 525-528.
13. Matsumoto M, Miki T, Shibasaki T, Kawaguchi M, Shinozaki H, et al. (2004) Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells. Proc Natl Acad Sci U S A 101: 8313-8318.
14. Williams JA, (2001) Intracellular signaling mechanisms activated by cholecystokinin-regulating synthesis and secretion of digestive enzymes in pancreatic acinar cells. Annu Rev Physiol 63: 77-97.
15. Kasai H, Li YX, Miyashita Y, (1993) Subcellular distribution of Ca2+ release channels underlying Ca2+ waves and oscillations in exocrine pancreas. Cell 74: 669-677.
16. Peterson OH, Tepikin AV, (2008) Polarized calcium signaling in exocrine gland cells. Annu Rev Physiol 70: 273-299.
17. Futatsugi A, Nakamura T, Yamada MK, Ebisui E, Nakamura K, et al. (2005) IP3 receptor type 2 and 3 mediate exocrine secretion underlying energy metabolism. Science 309: 2232-2234.
18. Nemoto T, Kimura R, Ito K, Tachikawa A, Miyashita Y, et al. (2001) Sequential-replenishment mechanism of exocytosis in pancreatic acini. Nat Cell Biol 3: 253-258.
19. Denk W, Strickler JH, Webb WW, (1990) Two-photon laser scanning fluorescence microscopy. Science 248: 73-76.
20. Takahashi N, Kishimoto T, Nemoto T, Kadowaki T, Kasai H, (2002) Fusion pore dynamics and insulin granule exocytosis in the pancreatic islet. Science 297: 1349-1352.
21. Nemoto T, Kojima T, Oshima A, Bito H, Kasai H, (2004) Stabilization of exocytosis by dynamic F-actin coating of zymogen granules in pancreatic acini. J Biol Chem 279: 37544-37550.
22. Oshima A, Kojima T, Dejima K, Hisa Y, Kasai H, et al. (2005) Two-photon microscopic analysis of acetylcholine-induced mucus secretion in guinea pig nasal glands. Cell Calcium 37: 359-370.
23. Fukuda M, (2003) Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. J Biol Chem 278: 15373-15380.
24. Chen X, Walker AK, Strahler JR, Simon ES, Tomanicek-Volk SI, et al. (2006) Organellar proteomics: analysis of pancreatic zymogen granule membranes. Mol Cell Proteomics 5: 306-312.
25. Ito K, Miyashita Y, Kasai H, (1997) Micromolar and submicromolar Ca2+ spikes regulating distinct cellular functions in pancreatic acinar cells. EMBO J 16: 242-251.
26. Poort C, Kramer MF, (1969) Effect of feeding on the protein synthesis in mammalian pancreas. Gastroenterology 57: 689-696.
27. Bedi KS, Cope GH, Williams MA, (1974) An electron microscopic-stereologic analysis of the zymogen granule content of the parotid glands of starved rabbits and of changes induced by feeding. Arch Oral Biol 19: 1127-1133.
28. Gomi H, Mori K, Itohara S, Izumi T, (2007) Rab27b is expressed in a wide range of exocytic cells and involved in the delivery of secretory granules near the plasma membrane. Mol Biol Cell 18: 4377-4386.
29. Saegusa C, Kanno E, Itohara S, Fukuda M, (2008) Expression of Rab27B-binding protein Slp1 in pancreatic acinar cells and its involvement in amylase secretion. Arch Biochem Biophys 475: 87-92.
30. Imai A, Yoshie S, Nashida T, Shimomura H, Fukuda M, (2006) Functional involvement of Noc2, a Rab27 effector, in rat parotid acinar cells. Arch Biochem Biophys 455: 127-135.
31. Wang CC, Ng CP, Lu L, Atlashkin V, Zhang W, et al. (2004) A role of VAMP8/endobrevin in regulated exocytosis of pancreatic acinar cells. Dev Cell 7: 359-371.
32. Petersen OH, (2003) Localization and regulation of Ca2+ entry and exit pathways in exocrine gland cells. Cell Calcium 33: 337-344.
33. Williams JA, (2008) Receptor-mediated signal transduction pathways and the regulation of pancreatic acinar cell function. Curr Opin Gastroenterol 24: 573-579.
34. Kiselyov K, Shin DM, Luo X, Ko SB, Muallem S, (2002) Ca2+ signaling in polarized exocrine cells. Adv Exp Med Biol 506: 175-183.
35. Patterson RL, Boehning D, Snyder SH, (2004) Inositol 1,4,5-trisphosphate receptors as signal integrators. Annu Rev Biochem 73: 437-465.
36. Luo X, Ahn W, Muallem S, Zeng W, (2004) Analyses of RGS Protein Control of Agonist-Evoked Ca2+ Signaling. Methods in Enzymology, vol 389, Regulators of G-protein signaling, part A. pp. 119-130 Elsevier Academic Press, San Diego, CA.
37. Henry L, Sheff D, (2008) Rab8 regulates basolateral secretory, but not recycling, traffic at the recycling endosome. Mol Biol Cell 19: 2059-2068.