Computational models for wall shear stress estimation in scaffolds: A comparative study of two complete geometries

Journal of Biomechanics

Volumn 45, Issue 9, 2012, Pages 1586-1592

  Maes, F ^a,c   Claessens, T ^a,c   Moesen, M ^b   Van Oosterwyck, H ^b   Van Ransbeeck, P ^a   Verdonck, P ^c  

^a UNIVERSITY COLLEGE GHENT   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c GHENT UNIVERSITY   (Belgium)

Author keywords

CFD; Perfusion; Scaffold; Tissue engineering; Wall shear stress

Indexed keywords

CELL DIFFERENTIATION; CFD MODELS; COMPARATIVE STUDIES; COMPUTATIONAL MODEL; DIFFERENT SIZES; DYNAMIC ENVIRONMENTS; FLOW CHANNELS; GEOMETRICAL COMPLEXITY; MATRIX FORMATION; MECHANICAL STIMULUS; MODEL SIZE; PERFUSION; SUBMODELS; SURFACE AREA; WALL SHEAR; WALL SHEAR STRESS;

COMPUTATIONAL FLUID DYNAMICS; FLUID MECHANICS; HYDROXYAPATITE; PORE SIZE; SCAFFOLDS; TISSUE ENGINEERING; TITANIUM;

SCAFFOLDS (BIOLOGY);

HYDROXYAPATITE; MOLECULAR SCAFFOLD; TITANIUM;

ARTICLE; COMPARATIVE STUDY; COMPUTATIONAL FLUID DYNAMICS; CONTROLLED STUDY; FLOW RATE; GEOMETRY; MATHEMATICAL MODEL; MECHANICAL STIMULATION; PRIORITY JOURNAL; PROCESS DEVELOPMENT; SHEAR STRESS; SURFACE PROPERTY;

BONE AND BONES; COMPUTER SIMULATION; DURAPATITE; HYDRODYNAMICS; POROSITY; STRESS, PHYSIOLOGICAL; TISSUE ENGINEERING; TISSUE SCAFFOLDS; TITANIUM;

EID: 84861194651     PISSN: 00219290     EISSN: 18732380     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2012.04.015     Document Type: Article

References (19)

1. Bancroft G.N., Sikavitsast V.I., van den Dolder J., Sheffield T.L., Ambrose C.G., Jansen J.A., Mikos A.G. Fluid flow increases mineralized matrix deposition in 3D perfusion culture of marrow stromal osteloblasts in a dose-dependent manner. Proceedings of the National Academy of Sciences of the United States of America 2002, 99:12600-12605.
2. Cartmell S.H., Porter B.D., Garcia A.J., Guldberg R.E. Effects of medium perfusion rate on cell-seeded three-dimensional bone constructs in vitro. Tissue Engineering 2003, 9:1197-1203.
3. Cioffi M., Boschetti F., Raimondi M.T., Dubini G. Modeling evaluation of the fluid-dynamic microenvironment in tissue-engineered constructs: a micro-CT based model. Biotechnology and Bioengineering 2006, 93:500-510.
4. Cioffi M., Kuffer J., Strobel S., Dubini G., Martin I., Wendt D. Computational evaluation of oxygen and shear stress distributions in 3D perfusion culture systems: macro-scale and micro-structured models. Journal of Biomechanics 2008, 41:2918-2925.
5. Glowacki J., Mizuno S., Greenberger J.S. Perfusion enhances functions of bone marrow stromal cells in three-dimensional culture. Cell Transplantation 1998, 7:319-326.
6. Holtorf H.L., Jansen J.A., Mikos A.G. Flow perfusion culture induces the osteoblastic differentiation of marrow stromal cell-scaffold constructs in the absence of dexamethasone. Journal of Biomedical Materials Research Part A 2005, 72A:326-334.
7. Jungreuthmayer C., Donahue S.W., Jaasma M.J., Al-Munajjed A.A., Zanghellini J., Kelly D.J., O'Brien F.J. A comparative study of shear stresses in collagen-glycosaminoglycan and calcium phosphate scaffolds in bone tissue-engineering bioreactors. Tissue Engineering Part A 2009, 15:1141-1149.
8. Kreke M.R., Huckle W.R., Goldstein A.S. Fluid flow stimulates expression of osteopontin and bone sialoprotein by bone marrow stromal cells in a temporally dependent manner. Bone 2005, 36:1047-1055.
9. Kreke M.R., Sharp L.A., Lee Y.W., Goldstein A.S. Effect of intermittent shear stress on mechanotransductive signaling and osteoblastic differentiation of bone marrow stromal cells. Tissue Engineering Part A 2008, 14:529-537.
10. Li D.Q., Tang T.T., Lu J.X., Dai K.R. Effects of flow shear stress and mass transport on the construction of a large-scale tissue-engineered bone in a perfusion bioreactor. Tissue Engineering Part A 2009, 15:2773-2783.
11. Maes F., Van Ransbeeck P., Van Oosterwyck H., Verdonck P. Modeling fluid flow through irregular scaffolds for perfusion bioreactors. Biotechnology and Bioengineering 2009, 103:621-630.
12. McGarry J.G., Klein-Nulend J., Mullender M.G., Prendergast P.J. A comparison of strain and fluid shear stress in stimulating bone cell responses-a computational and experimental study. Faseb Journal 2004, 18. 482-+.
13. Oudot S., Boissonnat J.D. Provably good sampling and meshing of surfaces. Graphical Models 2005, 67:405-451.
14. Raimondi M.T., Boschetti F., Falcone L., Fiore G.B., Remuzzi A., Marinoni E., Marazzi M., Pietrabissa R. Mechanobiology of engineered cartilage cultured under a quantified fluid-dynamic environment. Biomechanics and Modeling in Mechanobiology 2002, 1:69-82.
15. Raimondi M.T., Moretti M., Cioffi M., Giordano C., Boschetti F., Lagana K., Pietrabissa R. The effect of hydrodynamic shear on 3D engineered chondrocyte systems subject to direct perfusion. Biorheology 2006, 43:215-222.
16. Sandino C., Planell J.A., Lacroix D. A finite element study of mechanical stimuli in scaffolds for bone tissue engineering. Journal of Biomechanics 2008, 41:1005-1014.
17. Scaglione S., Wendt D., Miggino S., Papadimitropoulos A., Fato M., Quarto R., Martin I. Effects of fluid flow and calcium phosphate coating on human bone marrow stromal cells cultured in a defined 2D model system. Journal of Biomedical Materials Research Part A 2008, 86A:411-419.
18. Sikavitsas V.I., Bancroft G.N., Holtorf H.L., Jansen J.A., Mikos A.G. Mineralized matrix deposition by marrow stromal osteoblasts in 3D perfusion culture increases with increasing fluid shear forces. Proceedings of the National Academy of Sciences of the United States of America 2003, 100:14683-14688.
19. Voronov R., VanGordon S., Sikavitsas V.I., Papavassiliou D.V. Computational modeling of flow-induced shear stresses within 3D salt-leached porous scaffolds imaged via micro-CT. Journal of Biomechanics 2010, 43:1279-1286.