Shifting a complex debate on γ-secretase cleavage and Alzheimer's disease

EMBO Journal

Volumn 31, Issue 10, 2012, Pages 2237-2239

  Golde, Todd E ^a   Ran, Yong ^a   Felsenstein, Kevin M ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; FLAVINE ADENINE NUCLEOTIDE; GAMMA SECRETASE; NICASTRIN; NOTCH1 RECEPTOR; PRESENILIN;

ALZHEIMER DISEASE; ARTICLE; AUTOINFLAMMATORY DISEASE; CATALYSIS; DEMENTIA; DIABETIC NEPHROPATHY; GASTROINTESTINAL DYSPLASIA; GENE MUTATION; HUMAN; IN VITRO STUDY; NERVE DEGENERATION; POINT MUTATION; PRIORITY JOURNAL; REPERFUSION INJURY; RETINA MACULA DEGENERATION; SKIN CANCER; TRAUMATIC BRAIN INJURY; VASCULITIS;

ALZHEIMER DISEASE; AMYLOID; AMYLOID PRECURSOR PROTEIN SECRETASES; PRESENILIN-1;

EID: 84861194618     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2012.111     Document Type: Article

References (11)

1. Chávez-Gutiérrez L, Bammens L, Benilova I, Vandersteen A, Benurwar M, Borgers M, Lismont S, Zhou L, Van Cleynenbreugel S, Esselmann H, Wiltfang J, Serneels L, Karran E, Gijsen H, Schymkowitz J, Rousseau F, Broersen K, De Strooper B (2012) The mechanism of c-secretase dysfunction in familial Alzheimer disease. EMBO J 31: 2261-2274
2. Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297: 353-356 (Pubitemid 34790756)
3. Ho A, Shen J (2011) Presenilins in synaptic function and disease. Trends Mol Med 17: 617-624
4. Koo EH, Kopan R (2004) Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration. Nat Med 10(Suppl): S26-S33 (Pubitemid 38901864)
5. Quintero-Monzon O, Martin MM, Fernandez MA, Cappello CA, Krzysiak AJ, Osenkowski P, Wolfe MS (2011) Dissociation between the processivity and total activity of gamma-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations. Biochemistry 50: 9023-9035
6. Rizzo P, Osipo C, Foreman K, Golde T, Osborne B, Miele L (2008) Rational targeting of Notch signaling in cancer. Oncogene 27: 5124-5131
7. Shen J, Kelleher 3rd RJ (2007) The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism. Proc Natl Acad Sci USA 104: 403-409 (Pubitemid 46123039)
8. Takami M, Nagashima Y, Sano Y, Ishihara S, Morishima-Kawashima M, Funamoto S, Ihara Y (2009) gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment. J Neurosci 29: 13042-13052
9. Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T (2003) The role of presenilin cofactors in the gamma-secretase complex. Nature 422: 438-441 (Pubitemid 36411397)
10. Wang B, Yang W, Wen W, Sun J, Su B, Liu B, Ma D, Lv D, Wen Y, Qu T, Chen M, Sun M, Shen Y, Zhang X (2010) Gamma-secretase gene mutations in familial acne inversa. Science 330: 1065
11. Younkin SG (1998) The role of A beta 42 in Alzheimer's disease. J Physiol 92: 289-292