A novel function of IL-2: Chemokine/chemoattractant/retention receptor genes induction in Th subsets for skin and lung inflammation

Journal of Autoimmunity

Volumn 38, Issue 4, 2012, Pages 322-331

  Sharma, Rahul ^a   Sung, Sun Sang J ^a   Gaskin, Felicia ^a   Fu, Shu Man ^a   Ju, Shyr Te ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Cytokine; Regulatory T cell; Skin and lung inflammation; Trafficking receptor gene

Indexed keywords

CHEMOATTRACTANT; CHEMOKINE; CHEMOKINE RECEPTOR CXCR3; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; STAT6 PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CELL EXPANSION; CELLULAR IMMUNITY; CHEMOKINE CHEMOATTRACTANT RETENTION RECEPTOR GENE; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENE INDUCTION; GENE MUTATION; HELPER CELL; INFLAMMATION; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; SKIN INFLAMMATION; TH1 CELL; TH2 CELL;

ANIMALS; ANTIGENS, CD; CHEMOKINE CX3CL1; DERMATITIS; IMMUNOGLOBULIN E; INTEGRIN ALPHA CHAINS; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-2; INTERLEUKIN-4; MICE; MICE, KNOCKOUT; PNEUMONIA; RECEPTORS, CHEMOKINE; RECEPTORS, LEUKOTRIENE B4; STAT6 TRANSCRIPTION FACTOR; T-LYMPHOCYTES, HELPER-INDUCER; TH17 CELLS; TH2 CELLS;

EID: 84861192549     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2012.02.001     Document Type: Article

References (28)

1. + T regulatory cell-mediated suppression. Immunity 2009, 30:636-645.
2. Sakaguchi S., Wing K., Onishi Y., Prieto-Martin P., Yamaguchi T. Regulatory T cells: how do they suppress immune responses?. Int Immunol 2009, 21:1105-1111.
3. Fontenot J.D., Rasmussen J.P., Williams L.M., Dooley L., Farr A.G., Rudensky A.Y. Regulatory T cell lineage specification by the forkhead transcription factor Foxp3. Immunity 2005, 22:329-341.
4. Brunkow M.E., Jeffery E.W., Hjerrild K.A., Paeper B., Clark L.B., Yasayko S.A., et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet 2001, 27:68-73.
5. Wildin R.S., Ramsdell F., Peake J., Faravelli F., Casanova J.-L., Buist N., et al. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat Genet 2001, 27:18-20.
6. Chatila T.A., Blaeser F., Ho N., Lederman H.M., Voulgaropoulos C., Helms C., et al. JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome. J Clin Invest 2000, 106:R75-R81.
7. Lin W., Truong N., Grossman W.J., Haribhai D., Williams C.B., Wang J., et al. Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. J Allergy Clin Immunol 2005, 116:1106-1115.
8. Sharma R., Sharma P.R., Kim Y.-C., Leitinger N., Lee J.K., Fu S.M., et al. IL-2-controlled expression of multiple T cell trafficking genes and Th2 cytokines in the regulatory T cell-deficient scurfy mice: implication to multiorgan inflammation and control of skin and lung inflammation. J Immunol 2011, 186:1268-1278.
9. Zheng L., Sharma R., Gaskin F., Fu S.M., Ju S.T. A novel role of IL-2 in organ-specific autoimmune inflammation beyond regulatory T cell checkpoint: both IL-2 knockout and Fas mutation prolong lifespan of scurfy mice but by different mechanisms. J Immunol 2007, 179:8035-8041.
10. Sharma R., Jarjour W.N., Zheng L., Gaskin F., Fu S.M., Ju S.T. Large functional repertoire of regulatory T-cell suppressible autoimmune T cells in scurfy mice. J Autoimm 2007, 29:10-19.
11. + T cells in scurfy mice that display both CD103-dependent and independent inflammation. J Immunol 2009, 183:1065-1073.
12. Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001, 29:e45.26.
13. Villarino A.V., Tato C.M., Stumhofer J.S., Yao Z., Cui Y.K., Hennighausen L., et al. Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals. J Exp Med 2007, 204:65-71.
14. Miner K.T., Croft M. Generation, persistence, and modulation of Th0 effector cells: role of autocrine IL-4 and IFN-γ. J Immunol 1998, 160:5280-5287.
15. Metwali A., Blum A., Elliott D.E., Weinstock J.V. Interleukin-4 α chain and STAT6 signaling inhibit gamma interferon but not Th2 cytokine expression within schistosome granulomas. Infect Immun 2002, 70:5651-5658.
16. + T cells in an interleukin-10-dependent manner. Immunity 2011, 34:554-565.
17. Bettelli E., Carrier Y., Gao W., Korn T., Strom T.B., Oukka M., et al. Reciprocal development pathways for the generation of pathogenic TH17 and regulatory T cells. Nature 2006, 441:235-238.
18. Mach F., Sauty A., Iarossi A.S., Sukhova G.K., Neote K., Libby P., et al. Differential expression of three T lymphocyte-activating CXC chemokines by human atheroma-associated cells. J Clin Invest 1999, 104:1041-1050.
19. Cole K.E., Strick C.A., Paradis T.J., Ogborne K.T., Loetscher M., Gladue R.P., et al. Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. J Exp Med 1998, 187:2009-2021.
20. Nakajima C., Mukai T., Yamaguchi N., Morimoto Y., Park W.R., Iwasaki M. Induction of the chemokine receptor CXCR3 on TCR-stimulated T cells: dependence on the release from persistent TCR-triggering and requirement for IFN-gamma stimulation. Eur J Immunol 2002, 32:1792-1801.
21. Calabresi P.A., Yun S.H., Allie R., Whartenby K.A. Chemokine receptor expression on MBP-reactive T cells: CXCR6 is a marker of IFNgamma-producing effector cells. J Neuroimmunol 2002, 127:96-105.
22. Duroudier N.P., Tulah A.S., Sayers I. Leukotriene pathway genetics and pharmacogenetics in allergy. Allergy 2009, 64:823-839.
23. Imai T., Hieshima K., Haskell C., Baba M., Nagira M., Nishimura M., et al. Identification and molecular characterization of fractalkine receptor CXCR1, which mediates both leukocyte migration and adhesion. Cell 1997, 91:521-530.
24. Sather B.D., Treuting P., Perdue N., Miazqowicz M., Fontenot J.D., Rudensky A.Y., et al. Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease. J Exp Med 2007, 204:1335-1347.
25. Zheng Y., Chaudhry A., Kas A., deRoos P., Kim J.M., Chu T.T., et al. Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. Nature 2009, 458:351-356.
26. Hansen G., Berry G., DeKruyff R.H., Umetsu D.T. Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. J Clin Invest 1999, 103:175-183.
27. Randolph D.A., Stephens R., Carruthers C.J., Chaplin D.D. Cooperation between Th1 and Th2 cells in a murine model of eosinophilic airway inflammation. J Clin Invest 1999, 104:1021-1029.
28. Oyoshi M.K., He R., Kumar L., Yoon J., Geha R.S. Cellular and molecular mechanisms in atopic dermatitis. Adv Immunol 2009, 102:135-226.