Does uranium induce circulatory diseases? First results from a French cohort of uranium workers

Occupational and Environmental Medicine

Volumn 69, Issue 6, 2012, Pages 404-409

  Canu, Irina Guseva ^a   Garsi, Jerome Philippe ^a   Caër Lorho, Sylvaine ^a   Jacob, Sophie ^a   Collomb, Philippe ^b   Acker, Alain ^b   Laurier, Dominique ^a  

^a Institute of Radiological Protection and Nuclear Safety   (France)

^b AREVA NP   (France)

Author keywords

[No Author keywords available]

Indexed keywords

URANIUM DERIVATIVE;

ARTICLE; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; FRANCE; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; MORTALITY; OCCUPATIONAL EXPOSURE; PRIORITY JOURNAL; RISK ASSESSMENT; SMOKING;

ADULT; CARDIOVASCULAR DISEASES; FEMALE; FOLLOW-UP STUDIES; FRANCE; HUMANS; MALE; MIDDLE AGED; NUCLEAR POWER PLANTS; OCCUPATIONAL DISEASES; OCCUPATIONAL EXPOSURE; PROPORTIONAL HAZARDS MODELS; RADIATION INJURIES; RISK FACTORS; URANIUM; URANIUM COMPOUNDS;

EID: 84861187357     PISSN: 13510711     EISSN: 14707926     Source Type: Journal    
DOI: 10.1136/oemed-2011-100495     Document Type: Article

References (42)

1. McGale P, Darby SC, Hall P, et al. Incidence of heart disease in 35,000 women treated with radiotherapy for breast cancer in Denmark and Sweden. Radiother Oncol 2011;100:167-75.
2. Health Protection Agency. Circulation Disease Risk. Report of the Independent Advisory Group on Ionising Radiation. RCE-16: UK HPA: Oxford, 2010:110.
3. McGale P, Darby SC. Commentary: a dose-response relationship for radiationinduced heart disease-current issues and future prospects. Int J Epidemiol 2008;37:518-23. (Pubitemid 351804004)
4. Shimizu Y, Kodama K, Nishi N, et al. Radiation exposure and circulatory disease risk: Hiroshima and Nagasaki atomic bomb survivor data, 1950-2003. BMJ 2010;340:b5349.
5. Vrijheid M, Cardis E, Ashmore P, et al. Mortality from diseases other than cancer following low doses of ionizing radiation: results from the 15-Country Study of nuclear industry workers. Int J Epidemiol 2007;36:1126-35. (Pubitemid 350018557)
6. Azizova TV, Muirhead CR, Druzhinina MB, et al. Cerebrovascular diseases in the cohort of workers first employed at Mayak PA in 1948-1958. Radiat Res 2010;174:851-64.
7. Azizova TV, Muirhead CR, Druzhinina MB, et al. Cardiovascular diseases in the cohort of workers first employed at Mayak PA in 1948-1958. Radiat Res 2010;174:155-68.
8. Azizova TV, Muirhead CR, Moseeva MB, et al. Cerebrovascular diseases in nuclear workers first employed at the Mayak PA in 1948-1972. Radiat Environ Biophys 2011;50:539-52.
9. McGeoghegan D, Binks K, Gillies M, et al. The non-cancer mortality experience of male workers at British Nuclear Fuels plc, 1946-2005. Int J Epidemiol 2008;37:506-18. (Pubitemid 351804003)
10. Guseva Canu I, Cardis E, Metz-Flamant C, et al. French cohort of the uranium processing workers: mortality pattern after 30-year follow-up. Int Arch Occup Environ Health 2010;83:301-8.
11. Canu IG, Jacob S, Cardis E, et al. Reprocessed uranium exposure and lung cancer risk. Health Phys 2010;99:308-13.
12. McGale P, Darby SC. Low doses of ionizing radiation and circulatory diseases: a systematic review of the published epidemiological evidence. Radiat Res 2005;163:247-57. (Pubitemid 40293532)
13. Guseva Canu I, Molina G, Goldberg M, et al. [Development of a job exposure matrix for the epidemiological follow-up of workers in the French nuclear industry] (In French). Rev Epidemiol Sante Publique 2008;56:21-9.
14. Guseva Canu I, Paquet F, Goldberg M, et al. Comparative assessing for radiological, chemical, and physical exposures at the French uranium conversion plant: is uranium the only stressor? Int J Hyg Environ Health 2009;212:398-413.
15. International Commission on Radiological Protection (ICRP). Publication 66. Human Respiratory Tract Model for Radiological Protection. Oxford: Pergamon Press, 1994.
16. Chazel V, Houpert P, Ansoborlo E, et al. Variation of solubility, biokinetics and dose coefficient of industrial uranium oxides according to specific surface area. Radiat Prot Dosimetry 2000;88:223-31.
17. Chazel V, Houpert P, Paquet F, et al. Effect of absorption parameters on calculation of the dose coefficient: example of classification of industrial uranium compounds. Radiat Prot Dosimetry 2001;94:261-8. (Pubitemid 32303311)
18. Guseva Canu I, Jacob S, Cardis E, et al. Uranium carcinogenicity in human might depend on the physical and chemical nature of uranium and its isotopic composition: results from pilot epidemiological study of French nuclear workers. Cancer Causes Control 2011;22:1563-73.
19. Kaufman JD, Silverstein MA, Moure-Eraso R. Atrial fibrillation and sudden death related to occupational solvent exposure. Am J Ind Med 1994;25:731-5. (Pubitemid 24138409)
20. McNamee R, Burgess G, Dippnall WM, et al. Occupational noise exposure and ischaemic heart disease mortality. Occup Environ Med 2006;63:813-19. (Pubitemid 46024931)
21. Suadicani P, Hein HO, Gyntelberg F. Do physical and chemical working conditions explain the association of social class with ischaemic heart disease? Atherosclerosis 1995;113:63-9.
22. Yadegarfar G, McNamee R. The effect of shift work on ischaemic heart disease. Occup Environ Med 2008;65:575-6.
23. Guseva Canu I, Laurier D, Caër-Lorho S, et al. Characterisation of protracted low-level exposure to uranium in the workplace: a comparison of two approaches. Int J Hyg Environ Health 2010;213:270-7.
24. Korn EL, Graubard BI, Midthune D. Time-to-event analysis of longitudinal follow-up of a survey: choice of the time-scale. Am J Epidemiol 1997;145:72-80. (Pubitemid 27009060)
25. Walsh L. A short review of model selection techniques for radiation epidemiology. Radiat Environ Biophys 2007;46:205-13. (Pubitemid 47106461)
26. Lane RS, Frost SE, Howe GR, et al. Mortality (1950-1999) and cancer incidence (1969-1999) in the cohort of Eldorado uranium workers. Radiat Res 2010;174:773-85.
27. Schnelzer M, Hammer GP, Kreuzer M, et al. Accounting for smoking in the radonrelated lung cancer risk among German uranium miners: results of a nested casecontrol study. Health Phys 2010;98:20-8.
28. Tomasek L. Interaction of radon and smoking among Czech uranium miners. Radiat Prot Dosimetry 2011;145:238-42.
29. Lu S, Zhao FY. Nephrotoxic limit and annual limit on intake for natural U. Health Phys 1990;58:619-23.
30. Kurttio P, Harmoinen A, Saha H, et al. Kidney toxicity of ingested uranium from drinking water. Am J Kidney Dis 2006;47:972-82. (Pubitemid 43767321)
31. Wagner SE, Burch JB, Bottai M, et al. Hypertension and hematologic parameters in a community near a uranium processing facility. Environ Res 2010;110:786-97.
32. ATSDR. Agency for Toxic Substances and Disease Registry. Toxicological Profile for Uranium (Draft for Public Comment). US. Atlanta, GA: Department of Health and Human Service, Public Health Service, 2011.
33. Canu IG, Laurent O, Pires N, et al. Health effects of naturally radioactive water ingestion: the need for enhances studies. Environ Health Perspect 2011;119:1676-80.
34. Roberts E. Uranyl Nitrate. In: Voegtlin C, Hodge HC, eds. Pharmacology and Toxicology of Uranium Compounds. New York: McGraw-Hill Book Company, Inc, 1949:561-85.
35. Racine R, Grandcolas L, Grison S, et al. Cholesterol 7alpha-hydroxylase (CYP7A1) activity is modified after chronic ingestion of depleted uranium in the rat. J Steroid Biochem Mol Biol 2010;120:60-6.
36. Tissandie E, Gueguen Y, Lobaccaro JM, et al. In vivo effects of chronic contamination with depleted uranium on vitamin D3 metabolism in rat. Biochim Biophys Acta 2007;1770:266-72.
37. Morris KJ, Townsend KM, Batchelor AL. Studies of alveolar cell morphometry and mass clearance in the rat lung following inhalation of an enriched uranium dioxide aerosol. Radiat Environ Biophys 1989;28:141-54. (Pubitemid 19081128)
38. Schultz-Hector S, Trott KR. Radiation-induced cardiovascular diseases: is the epidemiologic evidence compatible with the radiobiologic data? Int J Radiat Oncol Biol Phys 2007;67:10-18. (Pubitemid 44959506)
39. Stewart FA, Hoving S, Russel NS. Vascular damage as an underlying mechanisme of cardiac and cerebrovascular toxicity in irradiated cancer patients. Radiat Res 2010;174:865-9.
40. Bramman JI, Sharpe RM, Thom D, et al. Metallic fission-product inclusions in irradiated oxide fuels. J Nucl Mater 1968;25:201-15.
41. Knol AB, de Hartog JJ, Boogaard H, et al. Expert elicitation on ultrafine particles: likelihood of health effects and causal pathways. Part Fibre Toxicol 2009;24:6-19.
42. Nusinovici S, Vacquier B, Leuraud K, et al. Mortality from circulatory diseases and low-level radon exposure in the French cohort study of uranium miners, 1946-1999. Scand J Work Environ Health 2010;36:378-83.