Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 11, 2012, Pages 3622-3634

  Shiohara, Hiroaki ^a   Nakamura, Tetsuya ^a   Kikuchi, Norihiko ^a   Ozawa, Tomonaga ^a   Nagano, Ryuichi ^a   Matsuzawa, Akane ^a   Ohnota, Hideki ^a   Miyamoto, Takahide ^b   Ichikawa, Kazuo ^c   Hashizume, Kiyoshi ^d  

^a KISSEI PHARMACEUTICAL CO LTD   (Japan)

^b Miyamoto Clinic   (Japan)

^c Ichikawa Clinic   (Japan)

^d MATSUMOTO DENTAL UNIVERSITY   (Japan)

Author keywords

Dyslipidemia; Hypothyroidism; Indane; Liver selectivity; Thyromimetics; TR selectivity

Indexed keywords

1 BENZYLOXY 2 ISOPROPYLBENZENE; 2 (4 BENZYLOXY 3 ISOPROPYLPHENOXY) 1,3,4 TRICHLORO 5 NITROBENZENE; 2 (4 BENZYLOXY 3 ISOPROPYLPHENOXY) 1,3,4 TRIMETHYL 5 NITROBENZENE; 2 BROMO 4 NITRO 5,6,7,8 TETRAHYDRONAPHTHALEN 1 OL; 2,3,6 TRICHLORO 4 NITROPHENOL; 2,3,6 TRIMETHYL 4 NITROPHENOL; 4 (4 AMINO 2,3,6 TRIMETHYLPHENOXY) 2 ISOPROPYLPHENOL; 4 (4 BENZYLOXY 3 ISOPROPYLPHENOXY) 2,3,5 TRICHLOROPHENYLAMINE; 4 (4 BENZYLOXY 3 ISOPROPYLPHENOXY) 5 BROMO 7 NITROINDANE; 4 (4 BENZYLOXY 3 ISOPROPYLPHENOXY) 5 METHYL 7 NITROINDANE; 5 (4 BENZYLOXY 3 ISOPROPYLPHENOXY) 6 BROMO 8 NITRO 1,2,3,4 TETRAHYDRONAPHTHALENE; 5 BROMO 7 NITROINDAN 4 OL; 5 BROMOINDAN 4 OL; 5 METHYL 7 NITROINDAN 4 OL; BIS (4 BENZYLOXY 3 ISOPROPYLPHENYL)IODONIUM TETRAFLUOROBORATE; CHOLESTEROL; EPROTIROME; ETHYL N [2,3,5 TRICHLORO 4 (4 HYDROXY 3 ISOPROPYLPHENOXY)PHENYL]MALONAMATE; ETHYL N [3 BROMO 4 (4 HYDROXY 3 ISOPROPYLPHENOXY) 5,6,7,8 TETRAHYDRONAPHTHALEN 1 YL]MALONAMIC ACID; ETHYL N [4 (4 BENZYLOXY 3 ISOPROPYLPHENOXY) 2,3,5 TRICHLOROPHENYL]MALONAMATE; ETHYL N [6 BROMO 7 (4 HYDROXY 3 ISOPROPYLPHENOXY)INDAN 4 YL]MALONAMATE; ETHYL N [7 (4 HYDROXY 3 ISOPROPYLPHENOXY) 6 METHYLINDAN 4 YL]OXAMATE; INDAN DERIVATIVE; MALONIC ACID; N [2,3,5 TRICHLORO 4 (4 HYDROXY 3 ISOPROPYLPHENOXY)PHENYL]MALONAMIC ACID; N [4 (4 HYDROXY 3NISOPROPYLPHENOXY) 2,3,5 TRIMETHYLPHENYL]MALONAMIC ACID; N [7 (4 HYDROXY 3 ISOPROPYLPHENOXY) 6 METHYLINDAN 4 YL]OXAMATE; THYROID HORMONE RECEPTOR BETA; THYROMIMETIC AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BINDING ASSAY; CARDIOTOXICITY; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; DYSLIPIDEMIA; HYPOTHYROIDISM; IN VITRO STUDY; MOLECULAR MODEL; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ARGININE; CHOLESTEROL; DISEASE MODELS, ANIMAL; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; DYSLIPIDEMIAS; HUMANS; INDANS; LIGANDS; LIVER; MALE; MALONATES; MODELS, MOLECULAR; MOLECULAR MIMICRY; MOLECULAR STRUCTURE; RATS; RATS, WISTAR; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; THYROID HORMONE RECEPTORS BETA;

ANIMALIA; RATTUS;

EID: 84861182041     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.03.056     Document Type: Article

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