High circulating folate and vitamin B-12 concentrations in women during pregnancy are associated with increased prevalence of atopic dermatitis in their offspring

Journal of Nutrition

Volumn 142, Issue 4, 2012, Pages 731-738

  Kiefte de Jong, Jessica C ^a   Timmermans, Sarah ^a   Jaddoe, Vincent W V ^a   Hofman, Albert ^a   Tiemeier, Henning ^a   Steegers, Eric A ^a   de Jongste, Johan C ^a   Moll, Henriette A ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CYANOCOBALAMIN; FOLIC ACID; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2);

ADULT; ARTICLE; ATOPIC DERMATITIS; DISEASE ASSOCIATION; DYSPNEA; FAMILY HISTORY; FEMALE; FIRST TRIMESTER PREGNANCY; FOLIC ACID BLOOD LEVEL; HUMAN; MALE; MATERNAL SMOKING; PREGNANCY; PROGENY; QUESTIONNAIRE; WHEEZING; ABNORMAL RESPIRATORY SOUND; BLOOD; CHEMICALLY INDUCED DISORDER; CHILD DEVELOPMENT; COHORT ANALYSIS; DIET SUPPLEMENTATION; FOLLOW UP; GENETICS; MATERNAL NUTRITION; NETHERLANDS; NEWBORN; PREVALENCE; PROSPECTIVE STUDY; SINGLE NUCLEOTIDE POLYMORPHISM;

CHILD DEVELOPMENT; COHORT STUDIES; DERMATITIS, ATOPIC; DIETARY SUPPLEMENTS; DYSPNEA; FEMALE; FOLIC ACID; FOLLOW-UP STUDIES; FOOD, FORTIFIED; HUMANS; INFANT, NEWBORN; MALE; MATERNAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); NETHERLANDS; POLYMORPHISM, SINGLE NUCLEOTIDE; PREGNANCY; PREGNANCY TRIMESTER, FIRST; PREVALENCE; PROSPECTIVE STUDIES; RESPIRATORY SOUNDS; VITAMIN B 12;

EID: 84861179361     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.111.154948     Document Type: Article

References (44)

1. Smithells RW, Sheppard S, Schorah CJ. Vitamin deficiencies and neural tube defects. Arch Dis Child. 1976;51:944-50.
2. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. MRC Vitamin Study Research Group. Lancet. 1991;338:131-7.
3. Kirke PN, Daly LE, Elwood JH. A randomised trial of low dose folic acid to prevent neural tube defects. The Irish Vitamin Study Group. Arch Dis Child. 1992;67:1442-6.
4. Pitkin RM. Folate and neural tube defects. Am J Clin Nutr. 2007;85: S285-8.
5. Tamura T, Picciano MF. Folate and human reproduction. Am J Clin Nutr. 2006;83:993-1016.
6. Waterland RA, Jirtle RL. Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases. Nutrition. 2004;20:63-8.
7. Friso S, Girelli D, Trabetti E, Olivieri O, Guarini P, Pignatti PF, Corrocher R, Choi SW. The MTHFR 1298A.C polymorphism and genomic DNA methylation in human lymphocytes. Cancer Epidemiol Biomarkers Prev. 2005;14:938-43.
8. Lucock M, Yates Z. Folic acid fortification: a double-edged sword. Curr Opin Clin Nutr Metab Care. 2009;12:555-64.
9. Hollingsworth JW, Maruoka S, Boon K, Garantziotis S, Li Z, Tomfohr J, Bailey N, Potts EN, Whitehead G, Brass DM, et al. In utero supplementation with methyl donors enhances allergic airway disease in mice. J Clin Invest. 2008;118:3462-9.
10. Adcock IM, Tsaprouni L, Bhavsar P, Ito K. Epigenetic regulation of airway inflammation. Curr Opin Immunol. 2007;19:694-700.
11. Prescott SL, Clifton V. Asthma and pregnancy: emerging evidence of epigenetic interactions in utero. Curr Opin Allergy Clin Immunol. 2009; 9:417-26.
12. Ha°berg SE, London SJ, Stigum H, Nafstad P, Nystad W. Folic acid supplements in pregnancy and early childhood respiratory health. Arch Dis Child. 2009;94:180-4.
13. Whitrow MJ, Moore VM, Rumbold AR, Davies MJ. Effect of supplemental folic acid in pregnancy on childhood asthma: a prospective birth cohort study. Am J Epidemiol. 2009;170:1486-93.
14. Jaddoe VW, van Duijn CM, van der Heijden AJ, Mackenbach JP, Moll HA, Steegers EA, Tiemeier H, Uitterlinden AG, Verhulst FC, Hofman A. The Generation R Study: design and cohort update 2010. Eur J Epidemiol. 2010;25:823-41.
15. Timmermans S, Jaddoe VW, Mackenbach JP, Hofman A, Steegers-Theunissen RP, Steegers EA. Determinants of folic acid use in early pregnancy in a multi-ethnic urban population in The Netherlands: the Generation R study. Prev Med. 2008;47:427-32.
16. Swertz O, Duimelaar P, Thijssen J. Migrants in the Netherlands 2004. Voorburg/Heerlen: Statistics Netherlands; 2004.
17. Asher MI, Keil U, Anderson HR, Beasley R, Crane J, Martinez F, Mitchell EA, Pearce N, Sibbald B, Stewart AW, et al. International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods. Eur Respir J. 1995;8:483-91.
18. Mohangoo AD, de Koning HJ, Hafkamp-de Groen E, van der Wouden JC, Jaddoe VW, Moll HA, Hofman A, Mackenbach JP, de Jongste JC, Raat H. A comparison of parent-reported wheezing or shortness of breath among infants as assessed by questionnaire and physician-interview: The Generation R Study. Pediatr Pulmonol. 2010; 45:500-7.
19. Martel MJ, Rey E, Malo JL, Perreault S, BeauchesneMF, Forget A, Blais L. Determinants of the incidence of childhood asthma: a two-stage casecontrol study. Am J Epidemiol. 2009;169:195-205.
20. Statistics N. Dutch standard classification of education 2003. Voorburg/Heerlen: Statistics Netherlands; 2004.
21. Twisk JW. Longitudinal data analysis. A comparison between generalized estimating equations and random coefficient analysis. Eur J Epidemiol. 2004;19:769-76.
22. Sterne JA, White IR, Carlin JB, Spratt M, Royston P, Kenward MG, Wood AM, Carpenter JR. Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls. BMJ. 2009; 338:b2393.
23. Rubin DB, Schenker N. Multiple imputation in health-care databases: an overview and some applications. Stat Med. 1991;10:585-98.
24. Haberg SE, London SJ, Nafstad P, Nilsen RM, Ueland PM, Vollset SE, NystadW. Maternal folate levels in pregnancy and asthma in children at age 3 years. J Allergy Clin Immunol. 2011;127:262-4, 4 e1.
25. Martinussen MP, Risnes KR, Jacobsen GW, Bracken MB. Folic acid supplementation in early pregnancy and asthma in children aged 6 years. Am J Obstet Gynecol. 2012;206:72 e1-7.
26. Magdelijns FJ, Mommers M, Penders J, Smits L, Thijs C. Folic acid use in pregnancy and the development of atopy, asthma, and lung function in childhood. Pediatrics. 2011;128:e135-44.
27. Granell R, Heron J, Lewis S, Davey Smith G, Sterne JA, Henderson J. The association between mother and child MTHFR C677T polymorphisms, dietary folate intake and childhood atopy in a populationbased, longitudinal birth cohort. Clin Exp Allergy. 2008;38:320-8.
28. Bekkers MB, Elstgeest LE, Scholtens S, Haveman A, de Jongste JC, KerkhofM, Koppelman GH, Gehring U, Smit HA, Wijga AH. Maternal use of folic acid supplements during pregnancy and childhood respiratory health and atopy: the PIAMA birth cohort study. Eur Respir J. Epub 2011 Oct 27.
29. Miyake Y, Sasaki S, Tanaka K, Hirota Y. Maternal B vitamin intake during pregnancy and wheeze and eczema in Japanese infants aged 16-24 months: The Osaka Maternal and Child Health Study. Pediatr Allergy Immunol. 2011;22:69-74.
30. Fedulov AV, Kobzik L. Allergy risk is mediated by dendritic cells with congenital epigenetic changes. Am J Respir CellMol Biol. 2011;44:285-92.
31. Winders BR, Schwartz RH, Bruniquel D. A distinct region of the murine IFN-gamma promoter is hypomethylated from early T cell development through mature naive and Th1 cell differentiation, but is hypermethylated in Th2 cells. J Immunol. 2004;173:7377-84.
32. Shin HJ, Park HY, Jeong SJ, Park HW, Kim YK, Cho SH, Kim YY, Cho ML, Kim HY, Mi KU, et al. STAT4 expression in human T cells is regulated by DNA methylation but not by promoter polymorphism. J Immunol. 2005;175:7143-50.
33. Lee GR, Kim ST, Spilianakis CG, Fields PE, Flavell RA. T helper cell differentiation: regulation by cis elements and epigenetics. Immunity. 2006;24:369-79.
34. Matsui EC, Matsui W. Higher serum folate levels are associated with a lower risk of atopy and wheeze. J Allergy Clin Immunol. 2009;123:1253-9 e2.
35. Thuesen BH, Husemoen LL, Ovesen L, Jorgensen T, Fenger M, Gilderson G, Linneberg A. Atopy, asthma, and lung function in relation to folate and vitamin B in adults. Allergy. 2010;65:1446-54.
36. Chatzi L, Torrent M, Romieu I, Garcia-Esteban R, Ferrer C, Vioque J, Kogevinas M, Sunyer J. Mediterranean diet in pregnancy is protective for wheeze and atopy in childhood. Thorax. 2008;63:507-13.
37. Choumenkovitch SF, Selhub J, Wilson PW, Rader JI, Rosenberg IH, Jacques PF. Folic acid intake from fortification in United States exceeds predictions. J Nutr. 2002;132:2792-8.
38. Rose G. Sick individuals and sick populations. Int J Epidemiol. 1985;14:32-8.
39. Caudri D, Wijga A, Schipper CM, Hoekstra M, Postma DS, Koppelman GH, Brunekreef B, Smit HA, de Jongste JC. Predicting the long-term prognosis of children with symptoms suggestive of asthma at preschool age. J Allergy Clin Immunol. 2009;124:903-10.
40. Spergel JM, Paller AS. Atopic dermatitis and the atopic march. J Allergy Clin Immunol. 2003;112:S118-27.
41. Thuesen BH, Husemoen LL, Ovesen L, Jorgensen T, Fenger M, Linneberg A. Lifestyle and genetic determinants of folate and vitamin B12 levels in a general adult population. Br J Nutr. 2010;103:1195-204.
42. Molloy AM, Daly S, Mills JL, Kirke PN, Whitehead AS, Ramsbottom D, Conley MR, Weir DG, Scott JM. Thermolabile variant of 5,10-methylenetetrahydrofolate reductase associated with low red-cell folates: implications for folate intake recommendations. Lancet. 1997;349: 1591-3.
43. Smulders YM, Blom HJ. The homocysteine controversy. J Inherit Metab Dis. 2011;34:93-9.
44. Gibson RS. Principles of nutritional assessment. 2nd ed. New York: Oxford University Press; 2005.