Phase II dose-ranging trial of the early bactericidal activity of PA-824

Antimicrobial Agents and Chemotherapy

Volumn 56, Issue 6, 2012, Pages 3027-3031

  Diacon, Andreas H ^a,b   Dawson, Rodney ^c   Du Bois, Jeannine ^b   Narunsky, Kim ^c   Venter, Amour ^a   Donald, Peter R ^a   Van Niekerk, Christo ^d,e   Erondu, Ngozi ^d,e   Ginsberg, Ann M ^d,e   Becker, Piet ^f   Spigelman, Melvin K ^d,e  

^a UNIVERSITY OF STELLENBOSCH   (South Africa)

^b Karl Bremer Hospital   (South Africa)

^c UNIVERSITY OF CAPE TOWN   (South Africa)

^d Global Alliance for TB Drug Development   (United States)

^e Global Alliance for TB Drug Development   (South Africa)

^f SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

6,7 DIHYDRO 2 NITRO 6 (4 TRIFLUOROMETHOXYBENZYLOXY) 5H IMIDAZO[2,1 B][1,3]OXAZINE; AGAR; ETHAMBUTOL; ISONIAZID; PYRAZINAMIDE; RIFAMPICIN;

ADULT; AREA UNDER THE CURVE; ARTICLE; BACTERICIDAL ACTIVITY; CLINICAL ARTICLE; COHORT ANALYSIS; COLONY FORMING UNIT; COMPARATIVE STUDY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG ERUPTION; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; HUMAN; LUNG TUBERCULOSIS; MALE; MAXIMUM PLASMA CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHASE 2 CLINICAL TRIAL; PNEUMONIA; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SPONTANEOUS PNEUMOTHORAX; SPUTUM SMEAR; TREATMENT DURATION; TREATMENT RESPONSE;

ADOLESCENT; ADULT; ANTITUBERCULAR AGENTS; DRUG ADMINISTRATION SCHEDULE; ETHAMBUTOL; FEMALE; HUMANS; ISONIAZID; MALE; MIDDLE AGED; NITROIMIDAZOLES; PYRAZINAMIDE; RIFAMPIN; TUBERCULOSIS, PULMONARY; YOUNG ADULT;

EID: 84861124193     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.06125-11     Document Type: Article

References (12)

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