Common variants of GSTP1, GSTA1, and TGFβ1 are associated with the risk of radiation-induced fibrosis in breast cancer patients

International Journal of Radiation Oncology Biology Physics

Volumn 83, Issue 2, 2012, Pages 504-511

  Terrazzino, Salvatore ^a   La Mattina, Pierdaniele ^b   Gambaro, Giuseppina ^b   Masini, Laura ^b   Franco, Pierfrancesco ^b   Canonico, Pier Luigi ^a   Genazzani, Armando A ^a   Krengli, Marco ^a,b  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^b University Hospital Maggiore della Carita   (Italy)

Author keywords

Breast cancer; Radiosensitivity; Radiotherapy; Single nucleotide polymorphisms; Subcutaneous fibrosis

Indexed keywords

ADJUVANT RADIOTHERAPY; BINARY LOGISTIC REGRESSION; BREAST CANCER; BREAST CONSERVING SURGERY; COMBINED ANALYSIS; DNA REPAIR; FIBROBLAST PROLIFERATION; GENETIC BASIS; GENETIC MARKERS; GENETIC VARIANTS; GENOMIC DNA; GENOTYPING; LATE EFFECTS; NORMAL TISSUE; ODDS RATIOS; OXIDATIVE STRESS RESPONSE; PERIPHERAL BLOOD; POLYMORPHIC VARIANT; RADIATION-INDUCED; RADIOSENSITIVITY; RESTRICTION FRAGMENT LENGTH POLYMORPHISM ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISMS; SIX GENES; SUBCUTANEOUS FIBROSIS;

CELL CULTURE; FIBROBLASTS; GENES; PLANTS (BOTANY); RADIOTHERAPY; REGRESSION ANALYSIS; SURGERY; TISSUE;

DERMATITIS;

DNA; GLUTATHIONE TRANSFERASE A1; GLUTATHIONE TRANSFERASE P1; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER SURGERY; CELL PROLIFERATION; CONTROLLED STUDY; DNA EXTRACTION; FIBROBLAST; FIBROSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN TISSUE; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; OXIDATIVE STRESS; PRIORITY JOURNAL; RADIATION SICKNESS; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ADULT; AGED; AGED, 80 AND OVER; BREAST; BREAST NEOPLASMS; CELL PROLIFERATION; DNA REPAIR; DNA-BINDING PROTEINS; FEMALE; FIBROBLASTS; FIBROSIS; GLUTATHIONE S-TRANSFERASE PI; GLUTATHIONE TRANSFERASE; HUMANS; MIDDLE AGED; NITRIC OXIDE SYNTHASE TYPE III; ODDS RATIO; OXIDATIVE STRESS; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE; RADIATION INJURIES; RADIATION TOLERANCE; REGRESSION ANALYSIS; RETROSPECTIVE STUDIES; RISK; SUBCUTANEOUS TISSUE; TRANSFORMING GROWTH FACTOR BETA1; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84861100412     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2011.06.2012     Document Type: Article

References (37)

1. B. Fisher, S. Anderson, and J. Bryant Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer N Engl J Med 347 2002 1233 1241 (Pubitemid 35176242)
2. L.J. Peters Radiation therapy tolerance limits: For one or for all? Cancer 77 1996 2379 2385 (Pubitemid 26162434)
3. G.C. Barnett, C.M. West, and A.M. Dunning Normal tissue reactions to radiotherapy: Towards tailoring treatment dose by genotype Nat Rev Cancer 9 2009 134 142
4. I. Turesson, J. Nyman, and E. Holmberg Prognostic factors for acute and late skin reactions in radiotherapy patients Int J Radiat Oncol Biol Phys 36 1996 1065 1075 (Pubitemid 27014492)
5. R.P. Hill, H.P. Rodemann, and J.H. Hendry Normal tissue radiobiology: From the laboratory to the clinic Int J Radiat Oncol Biol Phys 49 2001 353 365 (Pubitemid 32123609)
6. S.M. Bentzen, and M. Overgaard Relationship between early and late normal-tissue injury after postmastectomy radiotherapy Radiother Oncol 20 1991 159 165
7. S.M. Bentzen, J.Z. Skoczylas, and M. Overgaard Radiotherapy-related lung fibrosis enhanced by tamoxifen J Natl Cancer Inst 88 1996 918 922 (Pubitemid 26230643)
8. J. Johansen, J. Overgaard, and C. Rose Cosmetic outcome and breast morbidity in breast-conserving treatment: Results from the Danish DBCG-82TM national randomized trial in breast cancer Acta Oncol 41 2002 369 380
9. M. Deutsch, and J.C. Flickinger Patient characteristics and treatment factors affecting cosmesis following lumpectomy and breast irradiation Am J Clin Oncol 26 2003 350 353 (Pubitemid 36962075)
10. C. Lilla, C.B. Ambrosone, and S. Kropp Predictive factors for late normal tissue complications following radiotherapy for breast cancer Breast Cancer Res Treat 106 2007 143 150 (Pubitemid 47498097)
11. M. Mangoni, S. Bisanzi, and F. Carozzi Association between genetic polymorphisms in the XRCC1, XRCC3, XPD, GSTM1, GSTT1, MSH2, MLH1, MSH3, and MGMT genes and radiosensitivity in breast cancer patients Int J Radiat Oncol Biol Phys 81 2011 52 58
12. R.A. Gatti The inherited basis of human radiosensitivity Acta Oncol 40 2001 702 711 (Pubitemid 33081978)
13. C.N. Andreassen, J. Alsner, and M. Overgaard Prediction of normal tissue radiosensitivity from polymorphisms in candidate genes Radiother Oncol 69 2003 127 135 (Pubitemid 37485871)
14. C.N. Andreassen, and J. Alsner Genetic variants and normal tissue toxicity after radiotherapy: A systematic review Radiother Oncol 92 2009 299 309
15. N. Moullan, D.G. Cox, and S. Angèle Polymorphisms in the DNA repair gene XRCC1, breast cancer risk, and response to radiotherapy Cancer Epidemiol Biomarkers Prev 12 2003 1168 1174 (Pubitemid 37499439)
16. C.N. Andreassen, J. Alsner, and J. Overgaard TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early breast cancer Radiother Oncol 75 2005 18 21 (Pubitemid 40616789)
17. H. Edvardsen, V.N. Kristensen, and G.I. Grenaker Alnaes Germline glutathione S-transferase variants in breast cancer: Relation to diagnosis and cutaneous long-term adverse effects after two fractionation patterns of radiotherapy Int J Radiat Oncol Biol Phys 67 2007 1163 1171
18. N. Kuptsova, J. Chang-Claude, and S. Kropp Genetic predictors of long-term toxicities after radiation therapy for breast cancer Int J Cancer 122 2008 1333 1339 (Pubitemid 351287234)
19. J. Chang-Claude, C.B. Ambrosone, and C. Lilla Genetic polymorphisms in DNA repair and damage response genes and late normal tissue complications of radiotherapy for breast cancer Br J Cancer 100 2009 1680 1686
20. G. Giotopoulos, R.P. Symonds, and K. Foweraker The late radiotherapy normal tissue injury phenotypes of telangiectasia, fibrosis and atrophy in breast cancer patients have distinct genotype-dependent causes Br J Cancer 96 2007 1001 1007 (Pubitemid 46452279)
21. J.J. Pavy, J. Denekamp, and J. Letschert EORTC Late Effects Working Group. Late effects toxicity scoring: The SOMA scale Int J Radiat Oncol Biol Phys 31 1995 1043 1047
22. Lent SOMA scales for all anatomic sides Int J Radiat Oncol Biol Phys 31 1995 1049 1091
23. G.C. Barnett, C.E. Coles, and N.G. Burnet No association between SNPs regulating TGF-beta1 secretion and late radiotherapy toxicity to the breast: Results from the RAPPER study Radiother Oncol 97 2010 9 14
24. H. Landmark-Hoyvik, V. Dumeaux, and K.V. Reinertsen Blood gene expression profiling of breast cancer survivors experiencing fibrosis Int J Radiat Biol 79 2011 875 883
25. G.J. Prud'homme Pathobiology of transforming growth factor beta in cancer, fibrosis and immunologic disease, and therapeutic considerations Lab Invest 87 2007 1077 1091
26. C. Li, P.B. Wilson, and E. Levine TGF-beta1 levels in pre-treatment plasma identify breast cancer patients at risk of developing post-radiotherapy fibrosis Int J Cancer 84 1999 155 159 (Pubitemid 29133827)
27. C.B. Ambrosone, C. Tian, and J. Ahn Genetic predictors of acute toxicities related to radiation therapy following lumpectomy for breast cancer: A case-series study Breast Cancer Res 8 2006 R40
28. J.D. Hayes, and D.J. Pulford The glutathione S-transferase supergene family: Regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance Crit Rev Biochem Mol Biol 30 1995 445 600
29. P. Zimniak, B. Nanduri, and S. Pikula Naturally occurring human glutathione S-transferase GSTP1-1 isoforms with isoleucine and valine in position 104 differ in enzymic properties Eur J Biochem 224 1994 893 899 (Pubitemid 24288851)
30. B.F. Coles, F. Morel, and C. Rauch Effect of polymorphism in the human glutathione S-transferase A1 promoter on hepatic GSTA1 and GSTA2 expression Pharmacogenetics 11 2001 663 669 (Pubitemid 33078235)
31. J. Ping, H. Wang, and M. Huang Genetic analysis of glutathione Stransferase A1 polymorphism in the Chinese population and the influence of genotype on enzymatic properties Toxicol Sci 89 2006 438 443 (Pubitemid 43126002)
32. J.J. Letterio, and A.B. Roberts Regulation of immune responses by TGF-beta Annu Rev Immunol 16 1998 137 161
33. M.B. Sporn, and A.B. Roberts Transforming growth factor-beta: Multiple actions and potential clinical applications JAMA 262 1989 938 941 (Pubitemid 19208953)
34. G. Alsbeih, N. Al-Harbi, and K. Al-Hadyan Association between normal tissue complications after radiotherapy and polymorphic variations in TGFB1 and XRCC1 genes Radiat Res 173 2010 505 511
35. X. Yuan, Z. Liao, and Z. Liu Single nucleotide polymorphism at rs1982073:T869C of the TGFb1 gene is associated with the risk of radiation pneumonitis in patients with non-small-cell lung cancer treated with definitive radiotherapy J Clin Oncol 27 2009 3370 3378
36. B.A. Veldman, W. Spiering, and P.A. Doevendans The Glu298Asp polymorphism of the NOS 3 gene as a determinant of the baseline production of nitric oxide J Hypertens 20 2002 2023 2027 (Pubitemid 35305500)
37. C.N. Andreassen, J. Alsner, and M. Overgaard Risk of radiation-induced subcutaneous fibrosis in relation to single nucleotide polymorphisms in TGFB1, SOD2, XRCC1, XRCC3, APEX and ATM: A study based on DNA from formalin fixed paraffin embedded tissue samples Int J Radiat Biol 82 2006 577 586 (Pubitemid 44373575)