T-cell activation and neurodevelopmental outcomes in perinatally HIV-infected children

AIDS

Volumn 26, Issue 8, 2012, Pages 959-969

  Kapetanovic, Suad ^a   Aaron, Lisa ^b   Montepiedra, Grace ^b   Burchett, Sandra K ^c   Kovacs, Andrea ^d  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

HIV associated central nervous system disease; immune activation; neurodevelopmental outcomes; pediatric neuro AIDS; perinatally HIV infected children

Indexed keywords

ANTIRETROVIRUS AGENT; CD38 ANTIGEN; HLA DR ANTIGEN; NELFINAVIR; NEVIRAPINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PROTEINASE INHIBITOR; RITONAVIR;

AFRICAN AMERICAN; AGE DISTRIBUTION; ALGORITHM; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHILD; CHILD DEVELOPMENT; CYTOMEGALOVIRUS INFECTION; ETHNICITY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY (TOPIC); NERVOUS SYSTEM DEVELOPMENT; NEUROPROTECTION; PENETRANCE; PERINATAL INFECTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SEX RATIO; STATISTICAL MODEL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; VIRUS LOAD; WECHSLER INTELLIGENCE SCALE;

ADOLESCENT; ANTIGENS, CD38; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CENTRAL NERVOUS SYSTEM DISEASES; CHILD; CHILD, PRESCHOOL; FEMALE; FOLLOW-UP STUDIES; HIV INFECTIONS; HLA ANTIGENS; HUMANS; INFANT; MALE; TIME FACTORS;

EID: 84861098801     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e328352cee7     Document Type: Article

References (33)

1. Ghafouri M, Amini S, Khalili K, Sawaya BE. HIV-1 associated dementia: symptoms and causes. Retrovirology 2006; 3:28.
2. Sinclair E, Ronquillo R, Lollo N, Deeks SG, Hunt P, Yiannoutsos CT, et al. Antiretroviral treatment effect on immune activation reduces cerebrospinal fluid HIV-1 infection. J Acquir Immune Defic Syndr 2008; 47:544-552.
3. Lobato MN, Caldwell MB, Ng P, Oxtoby MJ. Encephalopathy in children with perinatally acquired human immunodeficiency virus infection. Pediatric Spectrum of Disease Clinical Consortium. J Pediatr 1995; 126 (5 Pt 1):710-715.
4. Donenberg GR, Pao M. Youths and HIV/AIDS: Psychiatry's role in a changing epidemic. J Am Acad Child Adolesc Psychiatry 2005; 44:728-747.
5. Nozyce ML, Lee SS, Wiznia A, Nachman S, Mofenson LM, Smith ME, et al. A behavioral and cognitive profile of clinically stable HIV-infected children. Pediatrics 2006; 117:763-770.
6. Mellins CA, Brackis-Cott E, Leu CS, Elkington KS, Dolezal C, Wiznia A, et al. Rates and types of psychiatric disorders in perinatally human immunodeficiency virus-infected youth and seroreverters. J Child Psychol Psychiatry 2009; 50:1131-1138.
7. Malee KM, Tassiopoulos K, Huo Y, Siberry GK, Williams PL, Hazra R, et al. Mental health functioning among children and adolescents with perinatal HIV infection and perinatal HIV exposure. AIDS Care 2011; 23:1533-1544; 27.
8. Kapetanovic S, Leister E, Nichols S, Miller T, Tassiopoulos K, Hazra R, et al. Relationship between markers of vascular dysfunction and neurodevelopmental outcomes in perinatally HIV-infected youth. AIDS 2010; 24:1481-1491.
9. Kapetanovic S, Wiegand RE, Dominguez K, Blumberg D, Bohannon B, Wheeling J, Rutstein R. Associations of medically documented psychiatric diagnoses and risky health behaviors in highly active antiretroviral therapy-experienced perinatally HIV-infected youth. AIDS Patient Care STDS 2011; 25:493-501.
10. Ellis RJ, Calero P, Stockin MD. HIV infection and the central nervous system: A primer. Neuropsychol Rev 2009; 19:144-151.
11. Joseph J, Clifford D, Douglas SD, Fox H, Gendelman HE, Gonzalez-Scarano F, et al. Planning future strategies for domestic and international NeuroAIDS research, July 24-25, 2008. J Neuroimmune Pharmacol 2009; 4:283-297.
12. Fauci A. Host factors and the pathogenesis of HIV-induced disease. Nature 1996; 384:529-534.
13. Jennings C, Rich K, Siegel J, Landay A. A phenotypic study of CD8R lymphocyte subsets in infants using three-color flow cytometry. Clin Immunol Immunopathol 1994; 71: 8-13.
14. Sánchez-Ramón S, Bellón JM, Resino S, Cantó-Nogués C, Gurbindo D, Ramos JT. Low blood CD8R T-lymphocytes and high circulating monocytes are predictors of HIV-1-associated progressive encephalopathy in children. Pediatrics 2003; 111:E168-E175.
15. Oyaizu N, McCloskey TW, Coronesi M, Chirmule N, Kalyanaraman VS, Pahwa S. Accelerated apoptosis in PBMC from HIV-1 infected patients and in CD4 crosslinked PBMC from normal individuals. Blood 1993; 82:3392-3400.
16. Oyaizu N, McCloskey TW, Than S, Hu R, Kalyanaraman VS, Pahwa S. Crosslinking of CD4 molecules upregulates Fas antigen expression in lymphocytes by inducing interferon-a and tumor necrosis factor-a secretion. Blood 1994; 84:2622-2631.
17. McArthur JC, Haughey N, Gartner S, Conant K, Pardo C, Nath A. Human immunodeficiency virus-associated dementia: An evolving disease. J Neurovirol 2003; 9:205-221.
18. Mekmullica J, Brouwers P, Charurat M, Paul M, Shearer W, Mendez H. Early immunological predictors of neurodevelopmental outcomes in HIV-infected children. Clin Infect Dis 2009; 48:338-346.
19. Tardieu M, Le CJ, Persoz A, Meyer L, Blanche S, Mayaux MJ. HIV-1-related encephalopathy in infants compared with children and adults. French Pediatric HIV Infection Study and the SEROCO Group. Neurology 2000; 54:1089-1095.
20. Kovacs A, Montepiedra G, Carey V, Pahwa S, Weinberg A, Frenkel L, et al. Immune reconstitution after receipt of highly active antiretroviral therapy in children with advanced or progressive HIV disease and complete or partial viral load response. J Infect Dis 2005; 192:296-302.
21. Bayley N. Bayley scales of infant development. 2nd ed. San Antonio, Texas: The Psychological Corporation; 1993.
22. Wechsler D. Wechsler preschool and primary scale of intelligence-revised. San Antonio, Texas: The Psychological Corporation; 1989.
23. Wechsler D. Wechsler intelligence scale for children. 3rd ed. San Antonio, Texas: The Psychological Corporation; 1991.
24. Malee K, Williams PL, Montepiedra G, Nichols S, Sirois PA, Storm D, et al. The role of cognitive functioning in medication adherence of children and adolescents with HIV infection. J Pediatr Psychol 2009; 34:164-175.
25. Letendre S, Fitzsimons C, Ellis RJ, Clifford D, Collier AC, Gelman B, et al. Correlates of CSF viral loads in 1221 volunteers of the CHARTER cohort. In: 17th Conference on Retroviruses and Opportunistic Infections; 16-19 February 2010; San Francisco, California, USA.
26. Centers for Disease Control and Prevention. 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. MMWR Morb Mortal Wkly Rep 1992; 41:1-19.
27. de Martino M, Rossi ME, Azzari C, Gelli MG, Galli L, Vierucci A. Different meaning of CD38 molecule expression on CD4R and CD8R cells of children perinatally infected with human immunodeficiency virus type 1 infection surviving longer than five years. Pediatr Res 1998; 43:752-758.
28. McCloskey TW, Cavaliere T, Bakshi S, Harper R, Fagin J, Kohn N, et al. Immunophenotyping of T lymphocytes by three-color flow cytometry in healthy newborns, children, and adults. Clin Immunol Immunopathol 1997; 84:46-55.
29. Ho HN, Hultin LE, Mitsuyasu RT, Matud JL, Hausner MA, Bockstoce D, et al. Circulating HIV-specific CD8R cytotoxic T cells express CD38 and HLA-DR antigens. J Immunol 1993; 150:3070-3079.
30. Schlesinger M, Peters V, Jiang JD, Roboz JP, Bekesi JG. Increased expression of activation markers on CD8 lymphocytes in children with human immunodeficiency virus-1 infection. Pediatr Res 1995; 38:390-396.
31. Bofill M, Mocroft A, Lipman M, Medina E, Borthwick NJ, Sabin CA, et al. Increased numbers of primed activated CD8RCD38RCD45ROR T cells predict the decline of CD4R T cells in HIV-1-infected patients. AIDS 1996; 10:827-834.
32. Paul ME, Mao C, Charurat M, Serchuck L, Foca M, Hayani K, et al. Women and Infants Transmission Study. Predictors of immunologic long-term nonprogression in HIV-infected children: Implications for initiating therapy. J Allergy Clin Immunol 2005; 115:848-855.
33. Wright E. Neurocognitive impairment and neuroCART. Curr Opin HIV AIDS 2011; 6:303-308.