Functional heartburn: Definition and management strategies

Current Gastroenterology Reports

Volumn 14, Issue 3, 2012, Pages 181-188

  Zerbib, Frank ^a   Des Varannes, Stanislas Bruley ^b   Simon, Mireille ^a   Galmiche, Jean Paul ^b  

^a HÔPITAL SAINT ANDRÉ   (France)

^b NANTES UNIVERSITY HOSPITAL   (France)

Author keywords

Esophageal impedance; Esophageal pH monitoring; Esophageal sensitivity; Functional esophageal disorders; Heartburn; Proton pump inhibitors; Rome III classification

Indexed keywords

AZD 1386; PLACEBO; PROTON PUMP INHIBITOR; TEGASEROD; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1 ANTAGONIST;

ANTIREFLUX OPERATION; ARTICLE; CLINICAL ASSESSMENT; CLINICAL FEATURE; CONTROLLED CLINICAL TRIAL (TOPIC); DISEASE CLASSIFICATION; DRUG SCREENING; ESOPHAGEAL PH MONITORING; ESOPHAGUS MANOMETRY; FUNCTIONAL HEARTBURN; GASTROESOPHAGEAL REFLUX; HEARTBURN; HUMAN; PATHOGENESIS; PREVALENCE; PSYCHOLOGICAL ASPECT; RISK FACTOR;

ESOPHAGEAL PH MONITORING; GASTROESOPHAGEAL REFLUX; HEARTBURN; HUMANS; PROTON PUMP INHIBITORS;

EID: 84861097428     PISSN: 15228037     EISSN: 1534312X     Source Type: Journal    
DOI: 10.1007/s11894-012-0255-7     Document Type: Article

References (58)

1. Locke 3rd GR, Talley NJ, Fett SL, et al. Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota. Gastroenterology. 1997;112:1448-56. (Pubitemid 27181367)
2. Carlsson R, Dent J, Bolling-Sternevald E, et al. The usefulness of a structured questionnaire in the assessment of symptomatic gastroesophageal reflux disease. Scand J Gastroenterol. 1998;33:1023-9. (Pubitemid 28505643)
3. Bredenoord AJ, Weusten BL, Smout AJ. Symptom association analysis in ambulatory gastro-oesophageal reflux monitoring. Gut. 2005;54:1810-7. (Pubitemid 41697683)
4. Sifrim D, Castell D, Dent J, et al. Gastro-oesophageal reflux monitoring: review and consensus report on detection and definitions of acid, non-acid, and gas reflux. Gut. 2004;53:1024-31. (Pubitemid 38824163)
5. Zerbib F, Roman S, Ropert A, et al. Esophageal pH-impedance monitoring and symptom analysis in GERD: a study in patients off and on therapy. Am J Gastroenterol. 2006;101:1956-63. (Pubitemid 44337616)
6. Clouse RE, Richter J, Heading RC. Functional esophageal disorders. In: Corazziari E, Talley NJ, Thompson WG, Whitehead WE, editors. Rome II - the functional gastrointestinal disorders. 2nd ed. MacLean: Degnon Associates; 2000. p. 247-98.
7. Galmiche JP, Clouse RE, Balint A, et al. Functional esophageal disorders. Gastroenterology. 2006;130:1459-65.
8. Fass R, Sifrim D. Management of heartburn not responding to proton pump inhibitors. Gut. 2009;58:295-309.
9. Shi G, Bruley des Varannes S, Scarpignato C, et al. Reflux related symptoms in patients with normal oesophageal exposure to acid. Gut. 1995;37:457-64.
10. Trimble KC, Douglas S, Pryde A, et al. Clinical characteristics and natural history of symptomatic but not excess gastroesophageal reflux. Dig Dis Sci. 1995;40:1098-104.
11. Watson RG, Tham TC, Johnston BT, et al. Double blind cross-over placebo controlled study of omeprazole in the treatment of patients with reflux symptoms and physiological levels of acid reflux - the "sensitive oesophagus". Gut. 1997;40:587-90. (Pubitemid 27278323)
12. Sacher-Huvelin S, Gournay J, Amouretti M, et al. Acid-sensitive esophagus: natural history and effect on the quality of life. Comparison with gastroesophageal reflux. Gastroenterol Clin Biol. 2000;24:911-6.
13. Dent J, Armstrong D, Delaney B, et al. Symptom evaluation in reflux disease: workshop background, processes, terminology, recommendations, and discussion outputs. Gut. 2004;53 Suppl 4:iv1-iv24. (Pubitemid 38580755)
14. Savarino E, Marabotto E, Zentilin P, et al. The added value of impedance-pH monitoring to Rome III criteria in distinguishing functional heartburn from non-erosive reflux disease. Dig Liver Dis. 2011;43:542-7.
15. Frazzoni M, Conigliaro R, Mirante VG, et al. The added value of quantitative analysis of on-therapy impedance-pH parameters in distinguishing refractory non-erosive reflux disease from functional heartburn. Neurogastroenterol Motil. 2011. doi:10.1039/C1AY05569K.
16. Aanen MC, Weusten BL, Numans ME, et al. Effect of protonpump inhibitor treatment on symptoms and quality of life in GERD patients depends on the symptom-reflux association. J Clin Gastroenterol. 2008;42:441-7. (Pubitemid 351572258)
17. Taghavi SA, Ghasedi M, Saberi-Firoozi M, et al. Symptom association probability and symptom sensitivity index: preferable but still suboptimal predictors of response to high dose omeprazole. Gut. 2005;54:1067-71. (Pubitemid 41025896)
18. Mainie I, Tutuian R, Shay S, et al. Acid and non-acid reflux in patients with persistent symptoms despite acid suppressive therapy: a multicentre study using combined ambulatory impedance-pH monitoring. Gut. 2006;55:1398-402. (Pubitemid 44476780)
19. Lam HG, Breumelhof R, van Berge Henegouwen GP, et al. Temporal relationships between episodes of non-cardiac chest pain and abnormal oesophageal function. Gut. 1994;35:733-6. (Pubitemid 24193210)
20. Slaughter JC, Goutte M, Rymer JA, et al. Caution about overinterpretation of symptom indexes in reflux monitoring for refractory gastroesophageal reflux disease. Clin Gastroenterol Hepatol. 2012; [Epub ahead of print].
21. Numans ME, Lau J, de Wit NJ, et al. Short-term treatment with proton-pump inhibitors as a test for gastroesophageal reflux disease: a meta-analysis of diagnostic test characteristics. Ann Intern Med. 2004;140:518-27.
22. Martinez SD, Malagon IB, Garewal HS, et al. Non-erosive reflux disease (NERD)-acid reflux and symptom patterns. Aliment Pharmacol Ther. 2003;17:537-45. (Pubitemid 36384812)
23. Zerbib F, Belhocine K, Simon M, et al. Clinical, but not oesophageal pH-impedance, profiles predict response to proton pump inhibitors in gastro-oesophageal reflux disease. Gut. 2012;61:501-6.
24. Savarino E, Pohl D, Zentilin P, et al. Functional heartburn has more in common with functional dyspepsia than with non-erosive reflux disease. Gut. 2009;58:1185-91.
25. Lee SY, Lee KJ, Kim SJ, et al. Prevalence and risk factors for overlaps between gastroesophageal reflux disease, dyspepsia, and irritable bowel syndrome: a population-based study. Digestion. 2009;79:196-201.
26. Nojkov B, Rubenstein JH, Adlis SA, et al. The influence of co-morbid IBS and psychological distress on outcomes and quality of life following PPI therapy in patients with gastrooesophageal reflux disease. Aliment Pharmacol Ther. 2008;27:473-82. (Pubitemid 351300853)
27. Jung HK, Halder S, McNally M, et al. Overlap of gastrooesophageal reflux disease and irritable bowel syndrome: prevalence and risk factors in the general population. Aliment Pharmacol Ther. 2007;26:453-61. (Pubitemid 47063139)
28. Fass R, Tougas G. Functional heartburn: the stimulus, the pain, and the brain. Gut. 2002;51:885-92. (Pubitemid 35408615)
29. Fass R, Naliboff B, Higa L, et al. Differential effect of long-term esophageal acid exposure on mechanosensitivity and chemosensitivity in humans. Gastroenterology. 1998;115:1363-73. (Pubitemid 28545986)
30. Knowles CH, Aziz Q. Visceral hypersensitivity in non-erosive reflux disease. Gut. 2008;57:674-83. (Pubitemid 351579984)
31. Vela MF, Craft BM, Sharma N, et al. Refractory heartburn: comparison of intercellular space diameter in documented GERD vs. functional heartburn. AmJ Gastroenterol. 2011;106:844-50.
32. Farre R, Fornari F, Blondeau K, et al. Acid and weakly acidic solutions impair mucosal integrity of distal exposed and proximal non-exposed human oesophagus. Gut. 2010;59:164-9.
33. Fried M, Feinle C. The role of fat and cholecystokinin in functional dyspepsia. Gut. 2002;51 Suppl 1:i54-7. (Pubitemid 34717721)
34. Meyer JH, Lembo A, Elashoff JD, et al. Duodenal fat intensifies the perception of heartburn. Gut. 2001;49:624-8. (Pubitemid 32989197)
35. Yang M, Li ZS, Xu XR, et al. Characterization of cortical potentials evoked by oesophageal balloon distention and acid perfusion in patients with functional heartburn. Neurogastroenterol Motil. 2006;18:292-9.
36. Kern MK, Birn RM, Jaradeh S, et al. Identification and characterization of cerebral cortical response to esophageal mucosal acid exposure and distention. Gastroenterology. 1998;115:1353-62. (Pubitemid 28545985)
37. Kern M, Hofmann C, Hyde J, et al. Characterization of the cerebral cortical representation of heartburn in GERD patients. Am J Physiol Gastrointest Liver Physiol. 2004;286:G174-81. (Pubitemid 38055851)
38. Yang M, Li ZS, Chen DF, et al. Quantitative assessment and characterization of visceral hyperalgesia evoked by esophageal balloon distention and acid perfusion in patients with functional heartburn, nonerosive reflux disease, and erosive esophagitis. Clin J Pain. 2010;26:326-31.
39. Fass R, Naliboff BD, Fass SS, et al. The effect of auditory stress on perception of intraesophageal acid in patients with gastroesophageal reflux disease. Gastroenterology. 2008;134:696-705. (Pubitemid 351312725)
40. Schey R, Dickman R, Parthasarathy S, et al. Sleep deprivation is hyperalgesic in patients with gastroesophageal reflux disease. Gastroenterology. 2007;133:1787-95. (Pubitemid 350180819)
41. Naliboff BD, Mayer M, Fass R, et al. The effect of life stress on symptoms of heartburn. Psychosom Med. 2004;66:426-34. (Pubitemid 38668416)
42. Johnston BT, Lewis SA, Collins JS, et al. Acid perception in gastro-oesophageal reflux disease is dependent on psychosocial factors. Scand J Gastroenterol. 1995;30:1-5.
43. Shapiro M, Green C, Bautista JM, et al. Functional heartburn patients demonstrate traits of functional bowel disorder but lack a uniform increase of chemoreceptor sensitivity to acid. Am J Gastroenterol. 2006;101:1084-91. (Pubitemid 43725324)
44. Furuta GT, Liacouras CA, Collins MH, et al. Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. Gastroenterology. 2007;133:1342-63.
45. Ponce J, Ortiz V, Maroto N, et al. High prevalence of heartburn and low acid sensitivity in patients with idiopathic achalasia. Dig Dis Sci. 2011;56:773-6.
46. Prakash C, Clouse RE. Value of extended recording time with wireless pH monitoring in evaluating gastroesophageal reflux disease. Clin Gastroenterol Hepatol. 2005;3:329-34. (Pubitemid 40488340)
47. Gonlachanvit S. Are rice and spicy diet good for functional gastrointestinal disorders? J Neurogastroenterol Motil;16:131-8.
48. Viazis N, Karamanolis G, Vienna E, et al. Selective-serotonin reuptake inhibitors for the treatment of hypersensitive esophagus. Therap Adv Gastroenterol. 2011;4:295-300.
49. Viazis N, Keyoglou A, Kanellopoulos AK, et al. Selective serotonin reuptake inhibitors for the treatment of hypersensitive esophagus: a randomized, double-blind, placebo-controlled study. Am J Gastroenterol. 2011;Epub ahead of print.
50. McDonald-Haile J, Bradley LA, Bailey MA, et al. Relaxation training reduces symptom reports and acid exposure in patients with gastroesophageal reflux disease. Gastroenterology. 1994;107:61-9. (Pubitemid 24195346)
51. Miner Jr. PB, Rodriguez-Stanley S, Proskin HM, et al. Tegaserod in patients with mechanical sensitivity and overlapping symptoms of functional heartburn and functional dyspepsia. Curr Med Res Opin. 2008;24:2159-72.
52. Krarup AL, Ny L, Astrand M, et al. Randomised clinical trial: the efficacy of a transient receptor potential vanilloid 1 antagonist AZD1386 in human oesophageal pain. Aliment Pharmacol Ther. 2011;33:1113-22.
53. Khajanchee YS, Hong D, Hansen PD, et al. Outcomes of antireflux surgery in patients with normal preoperative 24-hour pH test results. Am J Surg. 2004;187:599-603. (Pubitemid 38596878)
54. Campos GM, Peters JH, DeMeester TR, et al. Multivariate analysis of factors predicting outcome after laparoscopic Nissen fundoplication. J Gastrointest Surg. 1999;3:292-300.
55. Mainie I, Tutuian R, Agrawal A, et al. Combined multichannel intraluminal impedance-pH monitoring to select patients with persistent gastro-oesophageal reflux for laparoscopic Nissen fundoplication. Br J Surg. 2006;93:1483-7. (Pubitemid 44893649)
56. Broeders JA, Draaisma WA, Bredenoord AJ, et al. Impact of symptom-reflux association analysis on long-term outcome after Nissen fundoplication. Br J Surg. 2011;98:247-54.
57. Thompson SK, Cai W, Jamieson GG, et al. Recurrent symptoms after fundoplication with a negative pH study-recurrent reflux or functional heartburn? J Gastrointest Surg. 2009;13:54-60.
58. Arts J, Sifrim D, Rutgeerts P, et al. Influence of radiofrequency energy delivery at the gastroesophageal junction (the Stretta procedure) on symptoms, acid exposure, and esophageal sensitivity to acid perfusion in gastroesophagal reflux disease. Dig Dis Sci. 2007;52:2170-7. (Pubitemid 47246518)