C-peptide: A new mediator of atherosclerosis in diabetes

Mediators of Inflammation

Volumn 2012, Issue , 2012, Pages

  Vasic, Dusica ^a   Walcher, Daniel ^a  

^a UNIVERSITY OF ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); C PEPTIDE; CD34 ANTIGEN; CHEMOKINE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FRACTALKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; OXIDIZED LOW DENSITY LIPOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPID; PROTEIN KINASE B; RANTES; RIBOSOME RNA; SCAVENGER RECEPTOR; SELECTIN; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1; INSULIN; PROINSULIN;

ATHEROGENESIS; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CARDIOVASCULAR RISK; CHEMOTAXIS; CYTOKINE RELEASE; DEGRADATION; ENDOTHELIAL DYSFUNCTION; EXTRACELLULAR MATRIX; FAT CONTENT; FOAM CELL; HIGH RISK PATIENT; HUMAN; INTIMA; ISCHEMIC HEART DISEASE; LEUKOCYTE ADHERENCE; LIPOGENESIS; LYMPHOCYTE MIGRATION; MACROPHAGE; MICROVASCULARIZATION; MITOGENICITY; MONOCYTE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; REVIEW; RNA SYNTHESIS; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; T LYMPHOCYTE; ANIMAL; BIOLOGICAL MODEL; BLOOD; DIABETES MELLITUS; INFLAMMATION; INSULIN RESISTANCE; METABOLISM;

ANIMALS; ATHEROSCLEROSIS; C-PEPTIDE; DIABETES COMPLICATIONS; DIABETES MELLITUS; HUMANS; INFLAMMATION; INSULIN; INSULIN RESISTANCE; MODELS, BIOLOGICAL; PROINSULIN; SIGNAL TRANSDUCTION;

EID: 84861040648     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2012/858692     Document Type: Review

References (64)

1. Steiner D., Bell G., Tager H., DeGroot L., Chemistry and biosynthesis of pancreatic protein hormones Endocrinology 1995 Philadelphia, Pa, USA Saunders 1296 1328
2. Rubenstein A. H., Clark J. L., Melani F., Steiner D. F., Secretion of proinsulin C-Peptide by pancreatic cells and its circulation in blood Nature 1969 224 5220 697 699
3. Munte C. E., Vilela L., Kalbitzer H. R., Garratt R. C., Solution structure of human proinsulin C-peptide The FEBS Journal 2005 272 16 4284 4293 (Pubitemid 41166561)
4. Flatt P. R., Swanston-Flatt S. K., Hampton S. M., Bailey C. J., Marks V., Specific binding of the C-peptide of proinsulin to cultured B-cells from a transplantable rat islet cell tumor Bioscience Reports 1986 6 2 193 199
5. Ohtomo Y., Bergman T., Johansson B. L., Jrnvall H., Wahren J., Differential effects of proinsulin C-peptide fragments on Na+, K+- ATPase activity of renal tubule segments Diabetologia 1998 41 3 287 291 (Pubitemid 28254822)
6. Mutt V., Jorpes J. E., Structure of porcine cholecystokinin-pancreozymin. 1. Cleavage with thrombin and with trypsin European Journal of Biochemistry 1968 6 1 156 162
7. Wahren J., Ekberg K., Johansson J., Henriksson M., Pramanik A., Johansson B.-L., Rigler R., Jrnvall H., Role of C-peptide in human physiology American Journal of Physiology 2000 278 5 E759 E768
8. Kitamura T., Kimura K., Jung B. D., Makondo K., Okamoto S., Caas X., Sakane N., Yoshida T., Saito M., Proinsulin C-peptide rapidly stimulates mitogen-activated protein kinases in swiss 3T3 fibroblasts: requirement of protein kinase C, phosphoinositide 3-kinase and pertussis toxin-sensitive G-protein Biochemical Journal 2001 355 1 123 129 (Pubitemid 32304242)
9. Kitamura T., Kimura K., Jung B. D., Makondo K., Sakane N., Yoshida T., Saito M., Proinsulin C-peptide activates cAMP response element-binding proteins through the p38 mitogen-activated protein kinase pathway in mouse lung capillary endothelial cells Biochemical Journal 2002 366 3 737 744
10. Luppi P., Geng X., Cifarelli V., Drain P., Trucco M., C-peptide is internalised in human endothelial and vascular smooth muscle cells via early endosomes Diabetologia 2009 52 10 2218 2228
11. Zhong Z., Kotova O., Davidescu A., Ehrén I., Ekberg K., Jrnvall H., Wahren J., Chibalin A. V., C-peptide stimulates Na +,K + -ATPase via activation of ERK1/2 MAP kinases in human renal tubular cells Cellular and Molecular Life Sciences 2004 61 21 2782 2790 (Pubitemid 40022442)
12. Wahren J., Shafqat J., Johansson J., Chibalin A., Ekberg K., Jrnvall H., Molecular and cellular effects of C-peptidenew perspectives on an old peptide Experimental Diabesity Research 2004 5 1 15 23 (Pubitemid 38488732)
13. Samnegrd B., Jacobson S. H., Johansson B. L., Ekberg K., Isaksson B., Wahren J., Sjquist M., C-peptide and captopril are equally effective in lowering glomerular hyperfiltration in diabetic rats Nephrology Dialysis Transplantation 2004 19 6 1385 1391 (Pubitemid 38786728)
14. Nordquist L., Moe E., Sjquist M., The C-peptide fragment EVARQ reduces glomerular hyperfiltration in streptozotocin-induced diabetic rats Diabetes/Metabolism Research and Reviews 2007 23 5 400 405 (Pubitemid 47091244)
15. Marx N., Walcher D., Raichle C., Aleksic M., Bach H., Grb M., Hombach V., Libby P., Zieske A., Homma S., Strong J., C-peptide colocalizes with macrophages in early atherosclerotic lesions of diabetic subjects and induces monocytes chemotaxis in vitro Arteriosclerosis, Thrombosis, and Vascular Biology 2004 24 3 540 545 (Pubitemid 38326150)
16. Vasic D., Marx N., Sukhova G., Walcher C-peptide promotes the inflammatory process in atherosclerotic lesions of ApoE-deficient mice. Journal of Cellular and Molecular Medicine. In press
17. Ross R., Atherosclerosisan inflammatory disease The New England Journal of Medicine 1999 340 2 115 126
18. Reaven G. M., Role of insulin resistance in human disease (syndrome X): an expanded definition Annual Review of Medicine 1993 44 121 131 (Pubitemid 23117853)
19. Cybulsky M. I., Iiyama K., Li H., Zhu S., Chen M., Iiyama M., Davis V., Gutierrez-Ramos J. C., Connelly P. W., Milstone D. S., A major role for VCAM-1, but not ICAM-1, in early atherosclerosis The Journal of Clinical Investigation 2001 107 10 1255 1262 (Pubitemid 32494542)
20. Zernecke A., Shagdarsuren E., Weber C., Chemokines in atherosclerosis an update Arteriosclerosis, Thrombosis, and Vascular Biology 2008 28 11 1897 1908
21. Murdoch C., Finn A., Chemokine receptors and their role in inflammation and infectious diseases Blood 2000 95 10 3032 3043 (Pubitemid 30321151)
22. Janeway C. A. Jr., Medzhitov R., Innate immune recognition Annual Review of Immunology 2002 20 197 216 (Pubitemid 34293424)
23. Seneviratne A. N., Sivagurunathan B., Monaco C., Toll-like receptors and macrophage activation in atherosclerosis Clinica Chimica Acta 2012 413 1-2 3 14
24. Hansson G. K., Regulation of immune mechanisms in atherosclerosis Annals of the New York Academy of Sciences 2001 947 157 166 (Pubitemid 34059911)
25. Doran A. C., Meller N., McNamara C. A., Role of smooth muscle cells in the initiation and early progression of atherosclerosis Arteriosclerosis, Thrombosis, and Vascular Biology 2008 28 5 812 819 (Pubitemid 351544093)
26. Libby P., Current concepts of the pathogenesis of the acute coronary syndromes Circulation 2001 104 3 365 372 (Pubitemid 32666962)
27. Libby P., Aikawa M., Stabilization of atherosclerotic plaques: new mechanisms and clinical targets Nature Medicine 2002 8 11 1257 1262 (Pubitemid 35373557)
28. Haffner S. M., Lehto S., Rnnemaa T., Pyrl K., Laakso M., Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction The New England Journal of Medicine 1998 339 4 229 234 (Pubitemid 28350165)
29. Walcher D., Aleksic M., Jerg V., Hombach V., Zieske A., Homma S., Strong J., Marx N., C-peptide induces chemotaxis of human CD4-positive cells: involvement of pertussis toxin-sensitive G-proteins and phosphoinositide 3-kinase Diabetes 2004 53 7 1664 1670 (Pubitemid 38857022)
30. Aleksic M., Walcher D., Giehl K., Bach H., Grb M., Durst R., Hombach V., Marx N., Signalling processes involved in C-peptide-induced chemotaxis of CD4-positive lymphocytes Cellular and Molecular life Sciences 2009 66 11-12 1974 1984
31. Hills C. E., Brunskill N. J., Intracellular signalling by C-peptide Experimental Diabetes Research 2008 2008 8
32. Zhong Z., Davidescu A., Ehrén I., Ekberg K., Jrnvall H., Wahren J., Chibalin A. V., C-peptide stimulates ERK1/2 and JNK MAP kinases via activation of protein kinase C in human renal tubular cells Diabetologia 2005 48 1 187 197 (Pubitemid 40174672)
33. Walcher D., Babiak C., Poletek P., Rosenkranz S., Bach H., Betz S., Durst R., Grb M., Hombach V., Strong J., Marx N., C-peptide induces vascular smooth muscle cell proliferation: involvement of Src-kinase, phosphatidylinositol 3-kinase, and extracellular signal-regulated kinase 1/2 Circulation Research 2006 99 11 1181 1187 (Pubitemid 44808654)
34. Forst T., Kunt T., Wilhelm B., Weber M. M., Pftzner A., Role of C-Peptide in the regulation of microvascular blood flow Experimental Diabetes Research 2008 2008 8
35. Irving G. J., Zhang Q., Falcone J. C., Bratcher A. P., Rodriguez W. E., Tyagi S. C., Mechanisms of endothelial dysfunction with development of type 1 diabetes mellitus: role of insulin and C-peptide Journal of Cellular Biochemistry 2005 96 6 1149 1156 (Pubitemid 41681857)
36. Kitamura T., Kimura K., Makondo K., Furuya D. T., Suzuki M., Yoshida T., Saito M., Proinsulin C-peptide increases nitric oxide production by enhancing mitogen-activated protein-kinase-dependent transcription of endothelial nitric oxide synthase in aortic endothelial cells of Wistar rats Diabetologia 2003 46 12 1698 1705 (Pubitemid 38005332)
37. Al-Rasheed N. M., Chana R. S., Baines R. J., Willars G. B., Brunskill N. J., Ligandindependent activation of peroxisome proliferator-activated receptor-gamma by insulin and C-peptide in kidney proximal tubular cells: dependent on phosphatidylinositol 3-kinase activity The Journal of Biological Chemistry 2004 26 48 49747 49754 (Pubitemid 39577779)
38. Velarde V., Jenkins A. J., Christopher J., Lyons T. J., Jaffa A. A., Activation of MAPK by modified low-density lipoproteins in vascular smooth muscle cells Journal of Applied Physiology 2001 91 3 1412 1420 (Pubitemid 32803940)
39. Beijersbergen R. L., Bernards R., Cell cycle regulation by the retinoblastoma family of growth inhibitory proteins Biochimica et Biophysica Acta 1996 1287 2-3 103 120 (Pubitemid 26189190)
40. Harbour J. W., Dean D. C., Rb function in cell-cycle regulation and apoptosis Nature Cell Biology 2000 2 4 E65 E67
41. Mughal R. S., Scragg J. L., Lister P., Warburton P., Riches K., O'Regan D. J., Ball S. G., Turner N. A., Porter K. E., Cellular mechanisms by which proinsulin C-peptide prevents insulin-induced neointima formation in human saphenous vein Diabetologia 2010 53 8 1761 1771
42. Lindahl E., Nyman U., Zaman F., Palmberg C., Cascante A., Shafqat J., Takigawa M., Svendahl L., Jrnvall H., Joseph B., Proinsulin C-peptide regulates ribosomal RNA expression The Journal of Biological Chemistry 2010 285 5 3462 3469
43. Lindenblatt N., Braun B., Menger M. D., Klar E., Vollmar B., C-peptide exerts antithrombotic effects that are repressed by insulin in normal and diabetic mice Diabetologia 2006 49 4 792 800 (Pubitemid 43357554)
44. Suzuki L. A., Poot M., Gerrity R. G., Bornfeldt K. E., Diabetes accelerates smooth muscle accumulation in lesions of atherosclerosis: lack of direct growth-promoting effects of high glucose levels Diabetes 2001 50 4 851 860 (Pubitemid 32242644)
45. Johansson B. L., Borg K., Fernqvist-Forbes E., Kernell A., Odergren T., Wahren J., Beneficial effects of C-peptide on incipient nephropathy and neuropathy in patients with Type 1 diabetes mellitus Diabetic Medicine 2000 17 3 181 189 (Pubitemid 30212289)
46. Samnegrd B., Jacobson S. H., Jaremko G., Johansson B. L., Ekberg K., Isaksson B., Eriksson L., Wahren J., Sjquist M., C-peptide prevents glomerular hypertrophy and mesangial matrix expansion in diabetic rats Nephrology Dialysis Transplantation 2005 20 3 532 538 (Pubitemid 40378421)
47. Ekberg K., Brismar T., Johansson B. L., Lindstrom P., Juntti-Berggren L., Norrby A., Berne C., Arnqvist H. J., Bolinder J., Wahren J., C-peptide replacement therapy and sensory nerve function in type 1 diabetic neuropathy Diabetes Care 2007 30 1 71 76 (Pubitemid 46061294)
48. Hach T., Forst T., Kunt T., Ekberg K., Pftzner A., Wahren J., C-peptide improves adenosine-induced myocardial vasodilation in type 1 diabetes patients American Journal of Physiology 2004 286 1 E14 E19
49. Wallerath T., Kunt T., Forst T., Closs E. I., Lehmann R., Flohr T., Gabriel M., Schfer D., Gpfert A., Pftzner A., Beyer J., Frstermann U., Stimulation of endothelial nitric oxide synthase by proinsulin C-peptide Nitric Oxide 2003 9 2 95 102 (Pubitemid 37386378)
50. Johansson J., Ekberg K., Shafqat J., Henriksson M., Chibalin A., Wahren J., Jrnvall H., Molecular effects of proinsulin C-peptide Biochemical and Biophysical Research Communications 2002 295 5 1035 1040
51. Sima A. A. F., Zhang W., Grunberger G., Type 1 diabetic neuropathy and C-peptide Experimental Diabesity Research 2004 5 1 65 77 (Pubitemid 38477266)
52. Stridh S., Sllstrm J., Fridén M., Hansell P., Nordquist L., Palm F., C-peptide normalizes glomerular filtration rate in hyperfiltrating conscious diabetic rats Advances in Experimental Medicine and Biology 2009 645 219 225
53. Helivaara M. K., Teppo A. M., Karonen S. L., Tuominen J. A., Ebeling P., Plasma IL-6 concentration is inversely related to insulin sensitivity, and acute-phase proteins associate with glucose and lipid metabolism in healthy subjects Diabetes, Obesity and Metabolism 2005 7 6 729 736 (Pubitemid 41601078)
54. McNeill A. M., Rosamond W. D., Girman C. J., Heiss G., Golden S. H., Duncan B. B., East H. E., Ballantyne C., Prevalence of coronary heart disease and carotid arterial thickening in patients with the metabolic syndrome (The ARIC Study) American Journal of Cardiology 2004 94 10 1249 1254 (Pubitemid 39469942)
55. Scalia R., Coyle K. M., Levine B. J., Booth G., Lefer A. M., C-peptide inhibits leukocyte-endothelium interaction in the microcirculation during acute endothelial dysfunction The FASEB Journal 2000 14 14 2357 2364
56. Luppi P., Cifarelli V., Tse H., Piganelli J., Trucco M., Human C-peptide antagonises high glucose-induced endothelial dysfunction through the nuclear factor- B pathway Diabetologia 2008 51 8 1534 1543
57. Vish M. G., Mangeshkar P., Piraino G., Denenberg A., Hake P. W., O'Connor M., Zingarelli B., Proinsulin c-peptide exerts beneficial effects in endotoxic shock in mice Critical Care Medicine 2007 35 5 1348 1355 (Pubitemid 46642665)
58. Stary H. C., Chandler A. B., Dinsmore R. E., Fuster V., Glagov S., Insull W., Rosenfeld M. E., Schwartz C. J., Wagner W. D., Wissler R. W., A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis: a report from the Committee on Vascular Lesions of the council on arteriosclerosis, American heart association Circulation 1995 92 5 1355 1374
59. Bittl J. A., Advances in coronary angioplasty The New England Journal of Medicine 1996 335 17 1290 1302 (Pubitemid 26349272)
60. Liu B., Fisher M., Groves P., Down-regulation of the ERK1 and ERK2 mitogen-activated protein kinases using antisense oligonucleotides inhibits intimal hyperplasia in a porcine model of coronary balloon angioplasty Cardiovascular Research 2002 54 3 640 648 (Pubitemid 34595423)
61. Kobayashi Y., Naruse K., Hamada Y., Nakashima E., Kato K., Akiyama N., Kamiya H., Watarai A., Nakae M., Oiso Y., Nakamura J., Human proinsulin C-peptide prevents proliferation of rat aortic smooth muscle cells cultured in high-glucose conditions Diabetologia 2005 48 11 2396 2401 (Pubitemid 41618932)
62. Cifarelli V., Geng X., Styche A., Lakomy R., Trucco M., Luppi P., C-peptide reduces high-glucose-induced apoptosis of endothelial cells and decreases NAD(P)H-oxidase reactive oxygen species generation in human aortic endothelial cells Diabetologia 2011 54 10 2702 2712
63. Chima R. S., LaMontagne T., Piraino G., Hake P. W., Denenberg A., Zingarelli B., C-peptide, a novel inhibitor of lung inflammation following hemorrhagic shock American Journal of Physiology 2011 300 5 L730 L739
64. Kim S. T., Kim B. J., Lim D. M., Basal C-peptide level as a surrogate marker of subclinical atherosclerosis in type 2 diabetic patients Diabetes and Metabolism Journal 2011 35 1 41 49.