Expression of heat shock protein 70 in nasopharyngeal carcinomas: different expression patterns correlate with distinct clinical prognosis

Journal of Translational Medicine

Volumn 10, Issue 1, 2012, Pages

  Cai, Man Bo ^a,b   Wang, Xiao Pai ^a   Zhang, Jia Xing ^a   Han, Hui Qiong ^a   Liu, Chao Chun ^c   Bei, Jin Xin ^a   Peng, Ruo Jun ^a   Liang, Yi ^a   Feng, Qi Sheng ^a   Wang, Hai Yun ^a   Chen, Li Zhen ^a   Fu, Sha ^a   Kang, Tiebang ^a   Shao, Jian Yong ^a   Zeng, Yi Xin ^a  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^b UNIVERSITY OF SOUTH CHINA   (China)

^c WADSWORTH CENTER   (United States)

Author keywords

Expression; Heat shock protein 70; Nasopharyngeal carcinoma; Prognosis

Indexed keywords

HEAT SHOCK PROTEIN 70; HLA A ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER PROGNOSIS; CANCER SURVIVAL; CELLULAR DISTRIBUTION; CLINICAL FEATURE; DISEASE FREE SURVIVAL; DISTANT METASTASIS; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; NASOPHARYNX CARCINOMA; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PREDICTIVE VALUE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; UPREGULATION;

ADULT; AGED; FEMALE; HSP70 HEAT-SHOCK PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; PROGNOSIS; ROC CURVE; SURVIVAL ANALYSIS; TISSUE ARRAY ANALYSIS;

EID: 84861001896     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-10-96     Document Type: Article

References (50)

1. Wei WI, Sham JS. Nasopharyngeal carcinoma. Lancet 2005, 365(9476):2041-2054. 10.1016/S0140-6736(05)66698-6, 15950718.
2. Chang ET, Adami HO. The enigmatic epidemiology of nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev 2006, 15(10):1765-1777. 10.1158/1055-9965.EPI-06-0353, 17035381.
3. Klibi J, Niki T, Riedel A, Pioche-Durieu C, Souquere S, Rubinstein E, Le Moulec S, Guigay J, Hirashima M, Guemira F, Adhikary D, Mautner J, Busson P. Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells. Blood 2009, 113(9):1957-1966. 10.1182/blood-2008-02-142596, 19005181.
4. Baujat B, Audry H, Bourhis J, Chan AT, Onat H, Chua DT, Kwong DL, Al-Sarraf M, Chi KH, Hareyama M, Pignon JP, . MAC-NPC Collaborative Group Chemotherapy in locally advanced nasopharyngeal carcinoma: an individual patient data meta-analysis of eight randomized trials and 1753 patients. Int J Radiat Oncol Biol Phys 2006, 64(1):47-56. 10.1016/j.ijrobp.2005.06.037, 16377415, MAC-NPC Collaborative Group.
5. Al-Sarraf M, LeBlanc M, Giri PG, Fu KK, Cooper J, Vuong T, Forastiere AA, Adams G, Sakr WA, Schuller DE, Ensley JF. Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099. J Clin Oncol 1998, 16(4):1310-1317.
6. Langendijk JA, Leemans CR, Buter J, Berkhof J, Slotman BJ. The additional value of chemotherapy to radiotherapy in locally advanced nasopharyngeal carcinoma: a meta-analysis of the published literature. J Clin Oncol 2004, 22(22):4604-4612. 10.1200/JCO.2004.10.074, 15542811.
7. Chan SL, Ma BB. Novel systemic therapeutic for nasopharyngeal carcinoma. Expert Opin Ther Targets 2012, 16(Suppl 1):S63-S68.
8. Komatsu M, Tsukuda M, Matsuda H, Horiuchi C, Taguch T, Takahashi M, Nishimura G, Mori M, Niho T, Ishitoya J, Sakuma Y, Hirama M, Shiono O. Comparison of concurrent chemoradiotherapy versus induction chemotherapy followed by radiation in patients with nasopharyngeal carcinoma. Anticancer Res 2012, 32(2):681-686.
9. Patel SG, Shah JP. TNM staging of cancers of the head and neck: striving for uniformity among diversity. CA Cancer J Clin 2005, 55(6):242-258.
10. Ma BB, Chan AT. Recent perspectives in the role of chemotherapy in the management of advanced nasopharyngeal carcinoma. Cancer 2005, 103(1):22-31. 10.1002/cncr.20768, 15565580.
11. Chua DT, Ma J, Sham JS, Mai HQ, Choy DT, Hong MH, Lu TX, Min HQ. Long-term survival after cisplatin-based induction chemotherapy and radiotherapy for nasopharyngeal carcinoma: a pooled data analysis of two phase III trials. J Clin Oncol 2005, 23(6):1118-1124. 10.1200/JCO.2005.12.081, 15657403.
12. Hockel M, Vaupel P. Biological consequences of tumor hypoxia. Semin Oncol 2001, 28(2 Suppl 8):36-41.
13. Cui X, Yu ZY, Wang W, Zheng YQ, Liu W, Li LX. Co-Inhibition of HSP70/HSP90 Synergistically Sensitizes Nasopharyngeal Carcinoma Cells to Thermotherapy. Integr Cancer Ther 2011, [Epub ahead of print].
14. Gehrmann M, Radons J, Molls M, Multhoff G. The therapeutic implications of clinically applied modifiers of heat shock protein 70 (Hsp70) expression by tumor cells. Cell Stress Chaperones 2008, 13(1):1-10. 10.1007/s12192-007-0006-0, 2666213, 18347936.
15. Wei YQ, Zhao X, Kariya Y, Teshigawara K, Uchida A. Inhibition of proliferation and induction of apoptosis by abrogation of heat-shock protein (HSP) 70 expression in tumor cells. Cancer Immunol Immunother 1995, 40(2):73-78. 10.1007/BF01520287, 7882385.
16. Jaattela M, Wissing D, Kokholm K, Kallunki T, Egeblad M. Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases. EMBO J 1998, 17(21):6124-6134. 10.1093/emboj/17.21.6124, 1170939, 9799222.
17. Rerole AL, Jego G, Garrido C. Hsp70: anti-apoptotic and tumorigenic protein. Methods Mol Biol 2011, 787:205-230. 10.1007/978-1-61779-295-3_16, 21898238.
18. Tong YQ, Zhang ZJ, Liu B, Huang J, Liu H, Liu Y, Guo FJ, Zhou GH, Xie PL, Li YH, Zuo CH, Hu JY, Li GC. Autoantibodies as potential biomarkers for nasopharyngeal carcinoma. Proteomics 2008, 8(15):3185-3193. 10.1002/pmic.200700651, 18654982.
19. Liao Q, Zhao L, Chen X, Deng Y, Ding Y. Serum proteome analysis for profiling protein markers associated with carcinogenesis and lymph node metastasis in nasopharyngeal carcinoma. Clin Exp Metastasis 2008, 25(4):465-476. 10.1007/s10585-008-9152-8, 2413104, 18357507.
20. Calderwood SK, Theriault JR, Gong J. How is the immune response affected by hyperthermia and heat shock proteins?. Int J Hyperthermia 2005, 21(8):713-716. 10.1080/02656730500340794, 16338853.
21. Srivastava PK. Immunotherapy for human cancer using heat shock protein-peptide complexes. Curr Oncol Rep 2005, 7(2):104-108. 10.1007/s11912-005-0035-8, 15717943.
22. Srivastava PK, Menoret A, Basu S, Binder RJ, McQuade KL. Heat shock proteins come of age: primitive functions acquire new roles in an adaptive world. Immunity 1998, 8(6):657-665. 10.1016/S1074-7613(00)80570-1, 9655479.
23. Liu G, Yao K, Wang B, Zhou F, Chen Y, Li L, Chi J, Peng G. Reconstituted complexes of mycobacterial HSP70 and EBV LMP2A-derived peptides elicit peptide-specific cytotoxic T lymphocyte responses and anti-tumor immunity. Vaccine 2011, 29(45):7414-7423.
24. Min H, Hong M, Ma J, Zhang E, Zheng Q, Zhang J, Zhang F, Su Y, Qiu F. A new staging system for nasopharyngeal carcinoma in China. Int J Radiat Oncol Biol Phys 1994, 30(5):1037-1042. 10.1016/0360-3016(94)90307-7, 7961009.
25. Wang HY, Sun BY, Zhu ZH, Chang ET, To KF, Hwang JS, Jiang H, Kam MK, Chen G, Cheah SL, Lee M, Liu ZW, Chen J, Zhang JX, Zhang HZ, He JH, Chen FL, Zhu XD, Huang MY, Liao DZ, Fu J, Shao Q, Cai MB, Du ZM, Yan LX, Hu CF, Ng HK, Wee JT, Qian CN, Liu Q, Ernberg I, Ye W, Adami HO, Chan AT, Zeng YX, Shao JY. Eight-Signature Classifier for Prediction of Nasopharnyngeal Carcinoma Survival. J Clin Oncol 2011, 29(34):4516-4525. 10.1200/JCO.2010.33.7741, 22025164.
26. Cai MY, Tong ZT, Zhu W, Wen ZZ, Rao HL, Kong LL, Guan XY, Kung HF, Zeng YX, Xie D. H3K27me3 Protein Is a Promising Predictive Biomarker of Patients' Survival and Chemoradioresistance in Human Nasopharyngeal Carcinoma. Mol Med 2011, [Epub ahead of print].
27. Boroughs LK, Antonyak MA, Johnson JL, Cerione RA. A unique role for heat shock protein 70 and its binding partner tissue transglutaminase in cancer cell migration. J Biol Chem 2011, 286(43):37094-37107. 10.1074/jbc.M111.242438, 21896482.
28. Malusecka E, Krzyzowska-Gruca S, Gawrychowski J, Fiszer-Kierzkowska A, Kolosza Z, Krawczyk Z. Stress proteins HSP27 and HSP70i predict survival in non-small cell lung carcinoma. Anticancer Res 2008, 28(1B):501-506.
29. Thubashini M, Malathi N, Kannan L. Expression of heat shock protein70 in oral submucous fibrosis and oral squamous cell carcinoma: an immunohistochemical study. Indian J Dent Res 2011, 22(2):256-259. 10.4103/0970-9290.84299, 21891896.
30. Lu S, Tan Z, Wortman M, Dong Z. Regulation of heat shock protein 70-1 expression by androgen receptor and its signaling in human prostate cancer cells. Int J Oncol 2010, 36(2):459-467. 2929386, 20043082.
31. Zeng Y, Chen X, Larmonier N, Larmonier C, Li G, Sepassi M, Marron M, Andreansky S, Katsanis E. Natural killer cells play a key role in the antitumor immunity generated by chaperone-rich cell lysate vaccination. Int J Cancer 2006, 119(11):2624-2631. 10.1002/ijc.22150, 16989012.
32. Bei JX, Jia WH, Zeng YX. Familial and large-scale case-control studies identify genes associated with nasopharyngeal carcinoma. Semin Cancer Biol 2012, 22(2):96-106. 10.1016/j.semcancer.2012.01.012, 22313875.
33. Sengupta S, den Boon JA, Chen IH, Newton MA, Dahl DB, Chen M, Cheng YJ, Westra WH, Chen CJ, Hildesheim A, Sugden B, Ahlquist P. Genome-wide expression profiling reveals EBV-associated inhibition of MHC class I expression in nasopharyngeal carcinoma. Cancer Res 2006, 66(16):7999-8006. 10.1158/0008-5472.CAN-05-4399, 16912175.
34. Tang YL, Lu JH, Cao L, Wu MH, Peng SP, Zhou HD, Huang C, Yang YX, Zhou YH, Chen Q, Li XL, Zhou M, Li GY. Genetic variations of EBV-LMP1 from nasopharyngeal carcinoma biopsies: potential loss of T cell epitopes. Braz J Med Biol Res 2008, 41(2):110-116.
35. Lin JC, Cherng JM, Lin HJ, Tsang CW, Liu YX, Lee SP. Amino acid changes in functional domains of latent membrane protein 1 of Epstein-Barr virus in nasopharyngeal carcinoma of southern China and Taiwan: prevalence of an HLA A2-restricted 'epitope-loss variant'. J Gen Virol 2004, 85(7):2023-2034. 10.1099/vir.0.19696-0, 15218188.
36. Maranon C, Egui A, Carrilero B, Thomas MC, Pinazo MJ, Gascon J, Segovia M, Lopez MC. Identification of HLA-A *02:01-restricted CTL epitopes in Trypanosoma cruzi heat shock protein-70 recognized by Chagas disease patients. Microbes Infect 2011, 13(12-13):1025-1032.
37. Okochi M, Hayashi H, Ito A, Kato R, Tamura Y, Sato N, Honda H. Identification of HLA-A24-restricted epitopes with high affinities to Hsp70 using peptide arrays. J Biosci Bioeng 2008, 105(3):198-203. 10.1263/jbb.105.198, 18397768.
38. Mizukami S, Kajiwara C, Tanaka M, Kaisho T, Udono H. Differential MyD88/IRAK4 requirements for cross-priming and tumor rejection induced by heat shock protein 70-model antigen fusion protein. Cancer Sci 2012, Epub ahead of print.
39. Tischer S, Basila M, Maecker-Kolhoff B, Immenschuh S, Oelke M, Blasczyk R, Eiz-Vesper B. Heat shock protein 70/peptide complexes: potent mediators for the generation of antiviral T cells particularly with regard to low precursor frequencies. J Transl Med 2011, 9:175. 10.1186/1479-5876-9-175, 3217864, 21992180.
40. Liu G, Yao K, Wang B, Zhou F, Chen Y, Li L, Chi J, Peng G. Reconstituted complexes of mycobacterial HSP70 and EBV LMP2A-derived peptides elicit peptide-specific cytotoxic T lymphocyte responses and anti-tumor immunity. Vaccine 2011, 29(43):7414-7423. 10.1016/j.vaccine.2011.07.063, 21807054.
41. Wells AD, Rai SK, Salvato MS, Band H, Malkovsky M. Hsp72-mediated augmentation of MHC class I surface expression and endogenous antigen presentation. Int Immunol 1998, 10(5):609-617. 10.1093/intimm/10.5.609, 9645609.
42. Dressel R, Lubbers M, Walter L, Herr W, Gunther E. Enhanced susceptibility to cytotoxic T lymphocytes without increase of MHC class I antigen expression after conditional overexpression of heat shock protein 70 in target cells. Eur J Immunol 1999, 29(12):3925-3935. 10.1002/(SICI)1521-4141(199912)29:12<3925::AID-IMMU3925>3.0.CO;2-S, 10602000.
43. Kumar S, Deepak P, Acharya A. Autologous Hsp70 immunization induces anti-tumor immunity and increases longevity and survival of tumor-bearing mice. Neoplasma 2009, 56(3):259-268. 10.4149/neo_2009_03_259, 19309230.
44. Tamura Y, Peng P, Liu K, Daou M, Srivastava PK. Immunotherapy of tumors with autologous tumor-derived heat shock protein preparations. Science 1997, 278(5335):117-120. 10.1126/science.278.5335.117, 9311915.
45. Srivastava PK. Immunotherapy of human cancer: lessons from mice. Nat Immunol 2000, 1(5):363-366. 10.1038/80795, 11062489.
46. Parmiani G, Testori A, Maio M, Castelli C, Rivoltini L, Pilla L, Belli F, Mazzaferro V, Coppa J, Patuzzo R, et al. Heat shock proteins and their use as anticancer vaccines. Clin Cancer Res 2004, 10(24):8142-8146. 10.1158/1078-0432.CCR-04-1194, 15623587.
47. Nishikawa M, Otsuki T, Ota A, Guan X, Takemoto S, Takahashi Y, Takakura Y. Induction of tumor-specific immune response by gene transfer of Hsp70-cell-penetrating peptide fusion protein to tumors in mice. Mol Ther 2010, 18(2):421-428. 10.1038/mt.2009.203, 2839311, 19724264.
48. Rohde M, Daugaard M, Jensen MH, Helin K, Nylandsted J, Jaattela M. Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms. Genes Dev 2005, 19(5):570-582. 10.1101/gad.305405, 551577, 15741319.
49. Welch WJ, Feramisco JR. Nuclear and nucleolar localization of the 72,000-dalton heat shock protein in heat-shocked mammalian cells. J Biol Chem 1984, 259(7):4501-4513.
50. Kotoglou P, Kalaitzakis A, Vezyraki P, Tzavaras T, Michalis LK, Dantzer F, Jung JU, Angelidis C. Hsp70 translocates to the nuclei and nucleoli, binds to XRCC1 and PARP-1, and protects HeLa cells from single-strand DNA breaks. Cell Stress Chaperones 2009, 14(4):391-406. 10.1007/s12192-008-0093-6, 2728274, 19089598.