Identification of HLA-A24-restricted epitopes with high affinities to Hsp70 using peptide arrays

Journal of Bioscience and Bioengineering

Volumn 105, Issue 3, 2008, Pages 198-203

  Okochi, Mina ^a   Hayashi, Hiroki ^a   Ito, Akira ^a   Kato, Ryuji ^a   Tamura, Yasuaki ^b   Sato, Noriyuki ^b   Honda, Hiroyuki ^a  

^a NAGOYA UNIVERSITY   (Japan)

^b SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

antitumor vaccines; chaperone; HLA A24; Hsp70; peptide array; restricted epitopes

Indexed keywords

ANTITUMOR VACCINES; CHAPERONE; HLA-A24; HSP70; PEPTIDE ARRAYS; RESTRICTED EPITOPES;

ANTIGENS; BIOASSAY; CELL CULTURE; IMMUNOLOGY; MATHEMATICAL MODELS; VACCINES;

PEPTIDES;

CANCER ANTIBODY; EPITOPE; GLYCYLTYROSYLPROLYLVALYLTHREONYLASPARAGINYLALANYLVALYLISOLEUCINE; HLA A24 ANTIGEN; PEPTIDE DERIVATIVE; SERYLTYROSYLLYSYLGLYCYLGLUTAMYLTHREONYLLYSYLALANYLPHENYLALANINE; TUMOR ANTIGEN; TUMOR VACCINE; UNCLASSIFIED DRUG; VALYLPHENYLALANYLGLUTAMINYLHISTIDYLGLYCYLLYSYLVALYLGLUTAMYLISOLEUCINE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CELL LYSATE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DRUG PROTEIN BINDING; IMMUNIZATION; MOUSE; NONHUMAN; PEPTIDE ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; THYMOMA; TRANSGENIC MOUSE; VACCINATION;

EPITOPES; HLA-A ANTIGENS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; OLIGOPEPTIDES; PROTEIN ARRAY ANALYSIS;

MUS MUSCULUS;

EID: 41549140731     PISSN: 13891723     EISSN: None     Source Type: Journal    
DOI: 10.1263/jbb.105.198     Document Type: Article

References (30)

1. Suto R., and Srivastava P.K. A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides. Science 269 (1995) 1585-1588
2. Srivastava P. Roles of heat-shock proteins in innate and adaptive immunity. Nat. Rev. Immunol. 2 (2002) 185-194
3. Li Z., Menoret A., and Srivastava P. Roles of heat-shock proteins in antigen presentation and cross-presentation. Curr. Opin. Immunol. 14 (2002) 45-51
4. Singh-Jasuja H., Hilf N., Arnold-Schild D., and Schild H. The role of heat shock proteins and their receptors in the activation of the immune system. Biol. Chem. 382 (2001) 629-636
5. Srivastava P.K. Immunotherapy of human cancer: lessons from mice. Nat. Immunol. 1 (2000) 363-366
6. Wells A.D., and Malkovsky M. Heat shock proteins, tumor immunogenicity and antigen presentation: an integrated view. Immunol. Today 21 (2000) 129-132
7. Udono H., and Srivastava P.K. Heat shock protein 70-associated peptides elicit specific cancer immunity. J. Exp. Med. 178 (1993) 1391-1396
8. Blachere N.E., Li Z., Chandawarkar R.Y., Suto R., Jaikaria N.S., Basu S., Udono H., and Srivastava P.K. Heat shock protein-peptide complexes, reconstituted in vitro, elicit peptide specific cytotoxic T lymphocyte response and tumor immunity. J. Exp. Med. 186 (1997) 1315-1322
9. Udono H., Yamano T., Kawabata Y., Ueda M., and Yui K. Generation of cytotoxic T lymphocytes by MHC class I ligands fused to heat shock cognate protein 70. Int. Immunol. 13 (2001) 1233-1242
10. Enomoto Y., Bharti A., Khaleque A.A., Song B., Liu C., Apostolopoulos V., Xing P., Calderwood S.K., and Gong J. Enhanced Immunogenicity of heat shock protein 70 peptide complexes from dendritic cell-tumor fusion cells. J. Immunol. 177 (2006) 5946-5955
11. Ito A., Shinkai M., Honda H., Yoshikawa K., Saga S., Wakabayashi T., Yoshida J., and Kobayashi T. Heat shock protein 70 expression induces antitumor immunity during intracellular hyperthermia using magnetite nanoparticles. Cancer Immunol. Immunother. 52 (2003) 80-88
12. Srivastava P. Interaction of heat shock proteins with peptides and antigen presenting cells: chaperoning of the innate and adaptive immune responses. Annu. Rev. Immunol. 20 (2002) 395-425
13. Berwin B., and Nicchitta C.V. To find the road traveled to tumor immunity: the trafficking itineraries of molecular chaperones in antigen-presenting cells. Traffic 2 (2001) 690-697
14. Schild H., and Rammensee H.-G. gp96-the immune system's Swiss army knife. Nat. Immunol. 1 (2000) 100-101
15. Basu S., Binder R.J., Ramalingam T., and Srivastava P.K. CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin. Immunity 14 (2001) 303-313
16. Binder R.J., Han D.K., and Srivastava P.K. CD91: a receptor for heat shock protein gp96. Nat. Immunol. 1 (2000) 151-155
17. Castellino F., Boucher P.E., Eichelberg K., Mayhew M., Rothman J.E., Houghton A.N., and Germain R.N. Receptor-mediated uptake of antigen/heat shock protein complexes results in major histocompatibility complex class I antigen presentation via two distinct processing pathways. J. Exp. Med. 191 (2000) 1957-1964
18. Graner M.W., Zeng Y., Feng H., and Katsanis E. Tumor-derived chaperone-rich cell lysates are effective therapeutic vaccines against a variety of cancers. Cancer Immunol. Immunother. 52 (2003) 226-234
19. Melcher A., Todryk S., Hardwick N., Ford M., Jacobson M., and Vile R.G. Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression. Nat. Med. 4 (1998) 581-587
20. Faure O., Graff-Dubois S., Bretaudeau L., Derre L., Gross D.-A., Alves P.M., Cornet S., Duffour M.-T., Chouaib S., Miconnet I., Gregoire M., Jotereau F., Lemonnier F.A., Abastado J.-P., and Kosmatopoulos K. Inducible Hsp70 as target of anticancer immunotherapy: identification of HLA-A*0201-erstricted epitopes. Int. J. Cancer 108 (2004) 863-870
21. Frank R., and Döring R. Simultaneous multiple peptide synthesis under continuous flow conditions on cellulose paper discs as segmental solid supports. Tetrahedron 44 (1988) 6031-6040
22. Gao X., Pellois J.P., Na Y., Kim Y., Gulari E., and Zhou X. High density peptide microarrays. In situ synthesis and applications. Mol. Divers. 8 (2004) 177-187
23. Kato R., Kaga C., Kunimatsu M., Kobayashi T., and Honda H. Peptide array-based interaction assay of solid-bound peptides and anchorage-dependant cells and its effectiveness in cell-adhesive peptide design. J. Biosci. Bioeng. 101 (2006) 485-495
24. Okochi M., Nakanishi M., Kato R., Kobayashi T., and Honda H. High-throughput screening of cell death inducible short peptides from TNF-related apoptosis-inducing ligand sequence. FEBS Lett. 580 (2006) 885-889
25. Rüdiger S., Germeroth L., Schneider-Mergener J., and Bukau B. Substrate specificity of the DnaK chaperone determined by screening cellulose-bound peptide libraries. EMBO J. 16 (1997) 1501-1507
26. Schmid D., Baici A., Gehring H., and Christen P. Kinetics of molecular chaperone action. Science 263 (1994) 971-973
27. Ishii T., Udono H., Yamano T., Ohta H., Uenaka A., Ono T., Hizuta A., Tanaka N., Srivastava P.K., and Nakayama E. Isolation of MHC class I-restricted tumor antigen peptide and its precursor associated with heat shock proteins hsp70, hsp90, gp96. J. Immunol. 162 (1999) 1303-1309
28. Uenaka A., Ono T., Akisawa T., Wada H., Yasuda T., and Nakayama E. Identification of a unique antigen peptide pRL1 on BALB/c RL♂1 leukemia recognized by cytotoxic T lymphocytes and its relation to the Akt oncogene. J. Exp. Med. 180 (1994) 1599-1607
29. Rüdiger S., Germeroth L., Schneider-Mergener J., and Bukau B. Substrate specificity of the DnaK chaperone determined by screening cellulose-bound peptide libraries. EMBO J. 16 (1997) 1501-1507
30. Sasazuki, T., Tsuji, K., and Aizawa, M.: HLA 1991: Proceedings of the eleventh International Histocompatibility Workshop and Conference, held in Yokohama, Japan, 6-13 November, 1991. Oxford University Press, Oxford, Oxfordshire (1992).