Renal differentiation of amniotic fluid stem cells: Perspectives for clinical application and for studies on specific human genetic diseases

European Journal of Clinical Investigation

Volumn 42, Issue 6, 2012, Pages 677-684

  Rosner, Margit ^a   Schipany, Katharina ^a   Gundacker, Claudia ^a   Shanmugasundaram, Bharanidharan ^a   Li, Kongzhao ^a   Fuchs, Christiane ^a   Lubec, Gert ^a   Hengstschläger, Markus ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Amniotic fluid; Human genetics; MTOR; Pluripotent; Renal development; Stem cell

Indexed keywords

AMNIOTIC FLUID CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; EPIGENETICS; GENETIC DISORDER; HUMAN; KIDNEY DEVELOPMENT; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REGENERATIVE MEDICINE; REVIEW;

ADULT STEM CELLS; AMNIOTIC FLUID; CELL DIFFERENTIATION; CELL TRANSPLANTATION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; KIDNEY; KIDNEY FAILURE, CHRONIC; PLURIPOTENT STEM CELLS; REGENERATIVE MEDICINE;

EID: 84860917735     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2011.02622.x     Document Type: Review

References (80)

1. Aboushwareb T, Atala A. Stem cells in urology. Nat Clin Pract Urol 2008;5:621-31.
2. Benigni A, Morigi M, Remuzzi G. Kidney regeneration. Lancet 2010;375:1310-7.
3. Pino CJ, Humes HD. Stem cell technology for the treatment of acute and chronic renal failure. Transl Res 2010;156:161-8.
4. Bussolati B, Tetta C, Camussi G. Contribution of stem cells to kidney repair. Am J Nephrol 2008;28:813-22.
5. Abbattista MR, Schena FP. Stem cells and kidney diseases. Minerva Med 2004;95:411-8.
6. Sagrinati C, Ronconi E, Lazzeri E, Lasagni L, Romagnani P. Stem-cell approaches for kidney repair: choosing the right cells. Trends Mol Med 2008;14:277-85.
7. Iwatani H, Imai E. Kidney repair using stem cells: myth or reality as a therapeutic option? J Nephrol 2010;23:143-6.
8. Fioretto P, Steffens MW, Sutherland DE, Goetz FC, Mauer M. Reversal of lesions of diabetic nephropathy after pancreas transplantation. N Engl J Med 1998;339:69-75.
9. Murray P, Camussi G, Davies JA, Edgar D, Hengstschläger M, Kenny S et al. The KIDSTEM European research training network. Developing s stem cell based therapy to replace nephrons lost through reflux nephropathy. Organogenesis 2007;3:2-5.
10. Pleniceau O, Harari-Steinberg O, Dekel B. Concise review: kidney stem/progenitor cells: differentiate, sort out, or reprogram? Stem Cells 2010;28:1649-59.
11. Dekel B, Reisner Y. Engraftment of human early kidney precursors. Transpl Immunol 2004;12:241-7.
12. Kim SS, Gwak SJ, Han J, Park MH, Song KW, Kim BS. Regeneration of kidney tissue using in vitro cultured fetal kidney cells. Exp Mol Med 2008;40:361-9.
13. Lazzeri E, Crescioli C, Ronconi E, Mazzinghi B, Sagrinati C, Netti GS et al. Regenerative potential of embryonic renal multipotent progenitors in acute renal failure. J Am Soc Nephrol 2007;18:3128-38.
14. Perin L, Giuliani S, Sedrakyan S, DaSacco S, DeFilippo RE. Stem cell and regenerative science applications in the development of bioengineering of renal tissue. Pediatr Res 2008;63:467-71.
15. Maeshima A, Yamashita S, Nojima Y. Identification of renal progenitor-like tubular cells that participate in the regeneration process of the kidney. J Am Soc Nephrol 2003;14:3138-46.
16. Oliver JA, Maarouf O, Cheema FH, Martens TP, Al-Awqati Q. The renal papilla is a niche for adult kidney stem cells. J Clin Invest 2004;114:795-804.
17. Bussolati B, Bruno S, Grange C, Buttiglieri S, Deregibus MC, Cantino D et al. Isolation of renal progenitor cells from adult human kidney. Am J Pathol 2005;166:545-55.
18. Sagrinati C, Netti GS, Mazzinghi B, Lazzeri E, Liotta F, Frosali F et al. Isolation and characterization of multipotent progenitor cells from the Bowman's capsule of adult human kidneys. J Am Soc Nephrol 2006;17:2443-56.
19. Gupta S, Verfaillie C, Chmielewski D, Kren S, Eidman K, Connaire J et al. Isolation and characterization of kidney-derived stem cells. J Am Soc Nephrol 2006;17:3028-40.
20. D'Agati VD. Podocyte injury in focal segmental glomerulosclerosis: lessons from animal models. Kidney Int 2008;73:399-406.
21. Appel D, Kershaw DB, Smeets B, Yuan G, Fuss A, Frye B et al. Recruitment of podocytes from glomerular parietal epithelial cells. J Am Soc Nephrol 2009;20:333-43.
22. Bonventre JV. Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure. J Am Soc Nephrol 2003;14:S55-61.
23. Poulsom R, Forbes SJ, Hodivala-Dilke K, Ryan E, Wyles S, Navaratnarasah S et al. Bone marrow contributes to renal parenchymal turnover and regeneration. J Pathol 2001;195:229-35.
24. Morrigi M, Imberti B, Zoja C, Corna D, Tomasoni S, Abbate M et al. Mesenchymal stem cells are renotropic, helping to repair the kidney and improve function in acute renal failure. J Am Soc Nephrol 2004;15:1794-804.
25. Herrera MB, Bussolati B, Bruno S, Fonsato V, Romanazzi GM, Camussi G. Mesenchymal stem cells contribute to the renal repair of acute tubular epithelial injury. Int J Mol Med 2004;14:1035-41.
26. Yokoo T, Fukui A, Ohashi T, Miayzaki Y, Utsunomiya Y, Kawamura T et al. Xenobiotic kidney organogenesis from human mesenchymal stem cells using a growing rodent embryo. J Am Soc Nephrol 2006;17:1026-34.
27. Ito T, Suzuki A, Imai E, Okabe M, Hori M. Bone marrow is a reservoir of repopulating mesangial cells during glomerular remodelling. J Am Soc Nephrol 2001;12:2625-35.
28. Rookmaaker MB, Smits AM, Tolboom H, Van't Wout K, Martens AC, Goldschmeding R et al. Bone-marrow-derived cells contribute to glomerular endothelial repair in experimental glomerulonephritis. Am J Pathol 2003;163:553-62.
29. Sugimoto H, Mundel TM, Suund M, Xie L, Cosgrove D, Kalluri R. Bone marrow-derived stem cells repair basement membrane collagen defects and reverse genetic kidney disease. Proc Natl Acad Sci USA 2006;103:7321-6.
30. Tögel F, Hu Z, Weiss K, Isaac J, Lange C, Westenfelder C. Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms. Am J Physiol Renal Physiol 2005;289:F31-42.
31. Bi B, Schmitt R, Israilova M, Nishio H, Cantley LG. Stromal cells protect against acute tubular injury via an endocrine effect. J Am Soc Nephrol 2007;18:2486-96.
32. Fang TC, Otto WR, Rao J, Jeffery R, Hunt T, Alison MR et al. Haematopoietic lineage-committed bone marrow cells, but not cloned cultured mesenchymal stem cells, contribute to regeneration of renal tubular epithelium after HgCl 2 -induced acute tubular injury. Cell Prolif 2008;41:575-91.
33. Li B, Cohen A, Hudson TE, Motlagh D, Amrani DL, Duffield JS. Mobilized human hematopoietic stem/progenitor cells promote kidney repair after ischemia/reperfusion injury. Circulation 2010;121:2211-20.
34. Stokman G, Leemans JC, Claessen N, Weening JJ, Florquin S. Hematopoietic stem cell mobilization therapy accelerates recovery of renal function independent of stem cell contribution. J Am Soc Nephrol 2005;16:1684-92.
35. Stokman G, Leemans JC, Stroo I, Hoedemaeker I, Claessen N, Teske GJ et al. Enhanced mobilization of bone marrow cells does not ameliorate renal fibrosis. Nephrol Dial Transplant 2008;23:483-91.
36. Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS et al. Embryonic stem cell lines derived from human blastocysts. Science 1998;282:1145-7.
37. Kramer J, Steinhoff J, Klinger M, Fricke L, Rohwedel J. Cells differentiated from mouse embryonic stem cells via embryoid bodies express renal marker molecules. Differentiation 2006;74:91-104.
38. Steenhard BM, Isom KS, Cazcarro P, Dunmore JH, Godwin AR, St John PL et al. Integration of embryonic stem cells in metanephric kidney organ culture. J Am Soc Nephrol 2005;16:1623-31.
39. Bruce SJ, Rea RW, Steptoe AL, Busslinger M, Bertram JF, Perkins AC. In vitro differentiation of murine embryonic stem cells toward a renal lineage. Differentiation 2007;75:337-49.
40. Kim D, Dressler GR. Nephrogenic factors promote differentiation of mouse embryonic stem cells into renal epithelia. J Am Soc Nephrol 2005;16:3527-34.
41. Prusa A, Hengstschläger M. Amniotic fluid cells and human stem cell research - a new connection. Med Sci Monit 2002;8:253-7.
42. Prusa A, Marton E, Rosner M, Bernaschek G, Hengstschläger M. Oct-4 expressing cells in human amniotic fluid: a new source for stem cell research? Hum Reprod 2003;18:1489-93.
43. Siegel N, Rosner M, Hanneder M, Freilinger A, Hengstschläger M. Human amniotic fluid stem cells: a new perspective. Amino Acids 2008;35:291-3.
44. Pappa KI, Anagnou NP. Novel sources of fetal stem cells: where do they fit on the developmental continuum? Regen Med 2009;4:423-33.
45. Dobreva P, Pereira PNG, Deprest J, Zwijsen A. On the origin of amniotic stem cells: of mice and men. Int J Dev Biol 2010;54:761-77.
46. Tsai M-S, Lee J-L, Chang Y-J, Hwang S-M. Isolation of human multipotent mesenchymal stem cells from second-trimester amniotic fluid using a novel two-stage culture protocol. Hum Reprod 2004;19:1450-6.
47. Karlmark KR, Freilinger A, Marton E, Rosner M, Lubec G, Hengstschläger M. Activation of Oct-4 and Rex-1 promoters in human amniotic fluid cells. Int J Mol Med 2005;16:987-92.
48. Bossolasco P, Montemurro T, Cova L, Zangrossi S, Calzarossa C, Miatiotis S et al. Molecular and phenotypic characterization of human amniotic fluid cells and their differentiation potential. Cell Res 2006;16:329-36.
49. Kim J, Lee Y, Kim H, Hwang KJ, Kwon HC, Kim SK et al. Human amniotic fluid-derived stem cells have characteristics of multipotent stem cells. Cell Prolif 2007;40:75-90.
50. De Coppi P, Bartsch G, Siddiqui MM, Xu T, Santos TX, Perin L et al. Isolation of amniotic stem cell lines with potential for therapy. Nat Biotechnol 2007;25:100-6.
51. in t'Anker PS, Scherjon SA, Kleijburg-van der Keur C, Noort WA, Claas FHJ, Willemze R et al. Amniotic fluid as a novel source of mesenchymal stem cells for therapeutic transplantation. Blood 2003;102:1548-9.
52. Prusa AR, Marton E, Rosner M, Freilinger A, Bernachek G, Hengstschläger M. Stem cell marker expression in human trisomy 21 amniotic fluid cells and trophoblasts. J Neural Transm 2003;67:235-42.
53. Prusa AR, Marton E, Rosner M, Bettelheim D, Lubec G, Pollak A et al. Neurogenic cells in human amniotic fluid. Am J Obstet Gynecol 2004;191:309-14.
54. Tsai M-S, Hwang S-M, Tsai Y-L, Cheng F-C, Lee J-L, Chang Y-J. Clonal amniotic fluid-derived stem cells express characteristics of both mesenchymal and neural stem cells. Biol Reprod 2006;74:545-51.
55. Rehni AK, Singh N, Jaggi AS, Singh M. Amniotic fluid derived stem cells ameliorate focal cerebral ischaemia-reperfusion injury induced behavioural deficits in mice. Behav Brain Res 2007;183:95-100.
56. Kolambkar YM, Peister A, Soker S, Atala A, Guldberg RE. Chondrogenic differentiation of amniotic fluid-derived stem cells. J Mol Hist 2007;38:405-13.
57. Orciani M, Emanuelli M, Martino C, Pugnaloni A, Tranquilli AL, DiPrimio R. Potential role of culture mediums for successful isolation and neuronal differentiation of amniotic fluid stem cells. Int J Immunopathol Pharmacol 2008;21:595-602.
58. Ditadi A, de Coppi P, Picone O, Gautreau L, Smati R, Six E et al. Human and murine amniotic c-Kit+Lin- cells display hematopoietic activity. Blood 2009;113:3953-60.
59. Jezierski A, Gruslin A, Tremblay R, Ly D, Smith C, Turksen K et al. Probing stemness and neural commitment in human amniotic fluid cells. Stem Cell Rev Rep 2010;6:199-214.
60. Mareschi K, Rustichelli D, Comunanza V, DeFazio R, Cravero C, Morterra G et al. Multipotent mesenchymal stem cells from amniotic fluid originate neural precursors with functional voltage-gated sodium channels. Cytotherapy 2009;11:534-8.
61. Pfeiffer S, McLaughlin D. In vitro differentiation of human amniotic fluid-derived cells: augmentation towards a neuronal dopaminergic phenotype. Cell Biol Int 2010;34:959-67.
62. Valli A, Rosner M, Fuchs C, Siegel N, Bishop CE, Dolznig H et al. Embryoid body formation of human amniotic fluid stem cells depends on mTOR. Oncogene 2010;29:966-77.
63. Prasongchean W, Bagni M, Calzarossa C, De Coppi P, Ferretti P. Amniotic fluid stem cells increase embryo survival following injury. Stem Cells Dev 2011 Sep 9. [Epub ahead of print]
64. Siegel N, Rosner M, Hanneder M, Valli A, Hengstschläger M. Stem cells in amniotic fluid as new tools to study human genetic diseases. Stem Cell Rev 2007;3:256-64.
65. Pozzobon M, Ghionzoli M, DeCoppi P. ES, iPS, MSC and AFS cells. Stem cells exploitation for pediatric surgery: current research and perspective. Pediatr Surg Int 2010;26:3-10.
66. Abdulrazzak H, Moschidou D, Jones G, Guillot PV. Biological characteristics of stem cells from foetal, cord blood and extraembryonic tissues. J R Soc Interface 2010;7:S689-706.
67. Antonucci I, Stuppia L, Kaneko Y, Yu S, Tajiri N, Bae EC et al. Amniotic fluid as rich source of mesenchymal stromal cells for transplantation therapy. Cell Transplant 2011;20:789-95.
68. Perin L, Giuliani S, Jin D, Sedrakyan S, Carraro G, Habibian R et al. Renal differentiation of amniotic fluid stem cells. Cell Prolif 2007;40:936-48.
69. Siegel N, Valli A, Fuchs C, Rosner M, Hengstschläger M. Induction of mesenchymal/epithelial marker expression in human amniotic fluid stem cells. Reprod Biomed Online 2009;19:838-46.
70. Hauser PV, DeFazio R, Bruno S, Sdei S, Grange C, Bussolati B et al. Stem cells derived from human amniotic fluid contribute to acute kidney injury recovery. Am J Pathol 2010;177:2011-21.
71. DaSacco S, Sedrakyan S, Boldrin F, Giuliani S, Parnigotto PP, Habibian R et al. Human amniotic fluid as a potential new source of organ specific precursor cells for future regenerative medicine applications. Invest Urol 2010;183:1193-200.
72. Perin L, Sedrakyan S, Giuliani S, DaSacco S, Carraro G, Shiri L et al. Protective effect of human amniotic fluid stem cells in an immunodeficient mouse model of acute tubular necrosis. PLoS ONE 2010;5:1-16.
73. Siegel N, Rosner M, Unbekandt M, Fuchs C, Slabina N, Dolznig H et al. Contribution of human amniotic fluid stem cells to renal tissue formation depends on mTOR. Hum Mol Genet 2010;19:3320-31.
74. Rosner M, Siegel N, Fuchs C, Slabina N, Dolznig H, Hengstschläger M. Efficient siRNA-mediated prolonged gene silencing in human amniotic fluid stem cells. Nat Protoc 2010;5:1081-95.
75. Wu SM, Hochedlinger K. Harnessing the potential of induced pluripotent stem cells for regenerative medicine. Nat Cell Biol 2011;13:497-505.
76. Sengupta S, Peterson TR, Sabatini DM. Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell 2010;40:310-22.
77. Rosner M, Hanneder M, Siegel N, Valli A, Fuchs C, Hengstschläger M. The mTOR pathway and its role in human genetic diseases. Mutat Res 2008;659:284-92.
78. Yang Q, Guan K-L. Expanding mTOR signaling. Cell Res 2007;17:666-81.
79. Rosner M, Dolznig H, Fuchs C, Siegel N, Valli A, Hengstschläger M. CDKs as therapeutic targets for the human genetic disease tuberous sclerosis? Eur J Clin Invest 2009;39:1033-5.
80. Axwijk PH, Kluijt I, deJong D, Gille H, Teertstra J, Horenblas S. Hereditary causes of kidney tumours. Eur J Clin Invest 2010;40:433-9.