Multipotent mesenchymal stem cells from amniotic fluid originate neural precursors with functional voltage-gated sodium channels

Cytotherapy

Volumn 11, Issue 5, 2009, Pages 534-547

  Mareschi, Katia ^a,b   Rustichelli, Deborah ^a   Comunanza, Valentina ^b   De Fazio, Roberta ^c   Cravero, Cristina ^a   Morterra, Giulia ^a   Martinoglio, Barbara ^c   Medico, Enzo ^c   Carbone, Emilio ^b   Benedetto, Chiara ^c   Fagioli, Franca ^a  

^a REGINA MARGHERITA CHILDREN S HOSPITAL   (Italy)

^b NIS Center   (Italy)

^c UNIVERSITY OF TURIN   (Italy)

Author keywords

Amniotic fl uid; Mesenchymal stromal cells; Neuronal differentiation; Sodium channels

Indexed keywords

5' NUCLEOTIDASE; ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE; BETA1 INTEGRIN; ENDOGLIN; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR; HERMES ANTIGEN; OCTAMER TRANSCRIPTION FACTOR 4; TETRODOTOXIN; THY 1 ANTIGEN; TRANSCRIPTION FACTOR NANOG; VOLTAGE GATED SODIUM CHANNEL;

ADIPOCYTE; AMNIOCENTESIS; AMNION FLUID; ARTICLE; CARTILAGE CELL; CELL CULTURE; CELL DIFFERENTIATION; CELL EXPANSION; CELL GROWTH; CULTURE MEDIUM; CYTOFLUOROMETRY; ELECTROPHYSIOLOGY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOPHENOTYPING; IN VITRO STUDY; MESENCHYMAL STEM CELL; MULTIPOTENT STEM CELL; OSTEOBLAST; PHENOTYPE; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMNIOTIC FLUID; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELL SEPARATION; CELL SHAPE; CELLS, CULTURED; CULTURE MEDIA; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; IMMUNOPHENOTYPING; ION CHANNEL GATING; MESENCHYMAL STEM CELLS; MULTIPOTENT STEM CELLS; NEURONS; PREGNANCY; SODIUM CHANNELS;

EID: 70849127052     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.1080/14653240902974024     Document Type: Article

References (45)

1. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999; 284: 143-147
2. Kopen GC, P rockop DJ, Phinney DG. M arrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neo natal mouse brains. Proc Natl Acad Sci USA 1999; 96: 10711-10716
3. Sato Y, A raki H, Kato J, N akamura K, K awano Y, K obune M et al. Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion. Blood 2005; 106: 756-763
4. Campagnoli C, R oberts IA, K umar S, C ampagnoli C, Roberts IA, Kumar S, et al. Identifi cation of mesenchymal stem/progenitor cells in human fi rst-trimester fetal blood, liver, and bone marrow. Blood 2001; 98: 2396-2402
5. Hu Y, L iao L, W ang Q, M a L, M a G, J iang X, e t al. Isolation and identifi cation of mesenchymal stem cells from human fetal pancreas. J Lab Clin Med 2003; 141: 342-349
6. Romanov YA, S vintsitskaya VA, Smirnov VN. S earching for alternative sources of postnatal human mesenchymal stem cells: candidate MSC-like cells from umbilical cord. Stem Cells 2003; 21: 105-110
7. Kern S, E ichler H, S toeve J, K luter H, B ieback K. C omparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells 2006; 24: 1294-1301
8. Milunsky A, B ender CS. Failure of amniotic-fl uid cell growth with toxic tubes. N Engl J Med 1979; 301: 47-48
9. Hoehn H, Salk D. Morphological and biochemical heterogeneity of amniotic fl uid cells in culture. Methods Cell Biol 1982; 26: 11-34.
10. Gosden CM. A mniotic fl uid cell types and culture. B r Med Bull 1983; 39: 348-354
11. Prusa AR, H engstschlager M. A mniotic fl uid cells and human stem cell research: a new connection. Med Sci Monit 2002; 8: 253-257
12. In'tAnker PS, S cherjon SA, K leijburg-van der Keur C, Noort WA, Claas FH, Willemzer R, et al. Amniotic fl uid as a novel source of mesenchymal stem cells for therapeutic transplantation. Blood 2003; 102: 1548-1549
13. De Coppi P, B artsch G Jr, S iddiqui MM, X u T, S antos CC, Perin L, et al. Isolation of amniotic stem cell lines with potential for therapy. Nat Biotechnol 2007; 25: 100-106
14. Sessarego N, Parodi A, Podesta M, Benvenuto F, Mogni M, Raviolo V, et al. Multipotent mesenchymal stromal cells from amniotic fl uid: solid perspectives for clinical application. Haematologica 2008; 93: 339-346
15. Mareschi K, N ovara M, Rustichelli D, Ferrero I, Guido D, Carbone E, et al. Neural differentiation of hu man mesenchymal stem cells: evidence for expression of neural markers and EAG K-channel types. Exp Hematol 2006; 34: 1563-1572
16. Cesetti T, H ernandez-Guijo JM, Baldelli P, Carabelli V, Carbone E. Opposite action of beta1-and beta2-adrenergic receptors on Ca(V)1 L-channel current in rat adrenal chromaffi n cells. Neuroscience 2003; 23: 73-83.
17. Mareschi K, F errero I, Rustichelli D, Aschero S, Gammaitoni L, Aglietta M, et al. Expansion of mesenchymal stem cells isolated from pediatric and adult donor bone marrow. J Cell Biochem 2006; 97: 744-754
18. Hille B. I on Channels of Excitable Membranes . Sunderland: Sinauer Ass Inc , 2001.
19. Carbone E, Lux HD. Sodium channels in cultured chick dorsal root ganglion neurons. Eur Biophys J 1986; 13: 259-271
20. Tsai MS, H wang SM, Tsai YL, C heng FC, L ee JL, C hang YJ. Clonal amniotic fl uid-derived stem cells express characteristics of both mesenchymal and neural stem cells. Biol Reprod 2006; 74: 545-551
21. Roubelakis MG, Pappa KI, Bitsika V, Zagoura D, Vlahou A, Papadaki HA, et al. Molecular and proteomic characterization of human mesenchymal stem cells derived from amniotic fl uid: comparison to bone marrow mesenchymal stem cells. Stem Cells Dev 2007; 16: 931-952
22. Horwitz EM, Le Blanc K, D ominici M, M ueller I, Slaper-Cortenbach I, Marini FC, et al. Clarifi cation of the nomenclature for MSC: The International Society for Cellular Therapy position statement. Cytotherapy 2005; 7: 393-395
23. Dominici M, L e Blanc K, M ueller I, S laper-Cortenbach I, Marini F, Krause D et al. Minimal criteria for defi ning multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006; 8: 315-317
24. Niwa H, M iyazaki J, S mith AG. Quantitative expression of Oct-3/4 defi nes differentiation, dedifferentiation or selfrenewal of ES cells. Nat Genet 2000; 24: 372-376
25. Trosko JE. From adult stem cells to cancer stem cells: Oct-4 gene, cell-cell communication, and hormones during tumor promotion. Ann NY Acad Sci 2006; 1089: 36-58.
26. Chambers I, C olby D, R obertson M, N ichols J, L ee S, Tweedie S, et al. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 2003; 113: 643-655
27. Ye F, Zhou C, Cheng Q, Shen J, Chen H. S tem-cell-abundant proteins Nanog, Nucleostemin and Musashi1 are highly expressed in malignant cervical epithelial cells. BMC Cancer 2008; 8: 108.
28. Ezeh UI, T urek PJ, Reijo RA, Clark AT. H uman embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma. Cancer 2005; 104: 2255-2265
29. Carlin R, D avis D, Weiss M, S chultz B, T royer D. Expression of early transcription factors Oct-4, Sox-2 and Nanog by porcine umbilical cord (PUC) matrix cells. Reprod Biol Endocrinol 2006; 4: 8.
30. Bourguignon LY, P eyrollier K, X ia W, G ilad E. H yaluronan-CD44 interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug effl ux in breast and ovarian tumor cells. J Biol Chem 2008; 283: 17635-17651
31. Tondreau T, L agneaux L, D ejeneffe M, et al. B one marrow derived mesenchymal stem cells already express specifi c neural proteins before any differentiation. Differentiation 2004; 72: 319-326
32. Wislet-Gendebien S, H ans G, L eprince P, R igo JM, M oonen G, Rogister B. Plasticity of cultured mesenchymal stem cells: switch from nestin-positive to excitable neuron-like phenotype. Stem Cells 2005; 23: 392-402.
33. Buniatian G, Gebhardt R, Traub P, M ecke D, Osswald H. Dynamics of glial fi brillary acidic protein distribution in cultured glomerular podocytes and mesangial cells of the rat kidney. Biol Cell 1999; 91: 675-684
34. Neubauer K, K nittel T, Aurisch S, F ellmer P, R amadori G. Glial fi brillary acidic protein: a cell type specifi c marker for Ito cells in vivo and in vitro . J Hepatol 1996; 24: 719-730
35. Eliasson C, Sahlgren C, Berthold C, S takeberg J, C elis JE, Betsholtz C, et al. Intermediate fi lament protein partnership in astrocytes. J Biol Chem 1999; 274: 23996-24006
36. Frisen J, Johansson CB, T orok C, R isling M, L endahl U. Rapid, widespread, and longlasting induction of nestin contributes to the generation of glial scar tissue after CNS injury. J Cell Biol 1995; 131: 453-464
37. Lendahl U, Zimmerman LB, McKay RD. CNS stem cells express a new class of intermediate fi lament protein. Cell 1990; 60: 585-595
38. Garcia ADR, D oan NB, I mura T, B ush TG, Sofroniew MV. GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain. Nature Neurosci 2004; 7: 1233-1241
39. Catterall WA, P erez-Reyes E, S nutch TP, Striessnig J. International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels [Review]. Pharmacol Rev 2005; 57: 411-425
40. Meadows LS, C hen YH, P owell AJ, C lare JJ, Ragsdale DS. Functional modulation of human brain Nav1.3 sodium channels, expressed in mammalian cells, by auxiliary-1,-2 and-3 subunits. Neuroscience 2002; 114: 745-753
41. Fenwick EM, M arty A, N eher E. S odium and calcium channels in bovine chromaffi n cells. J Physiol 1982; 356: 565-585
42. Colbert CM, J ohnston D. A xonal action-potential initiation and Na-channel densities in the soma and axon initial segment of subicular pyramidal neurons. J Neurosci 1996; 16: 676-686
43. Feldman DH, T hischimidt JS, P eel AL, P apke RL, R eier PJ. Differentiation of ionic currents in CNS progenitor cells: dependence upon substrate attachment and epidermal growth fact. Exp Neurol 1996; 140: 206-217
44. Barres BA, Chun LY, Corey DP. Glial and neuronal forms of the voltage-dependent sodium channel. Neuron 1989; 2: 13754-13788
45. Li GR, S un H, D eng X, L au CP. C haracterization of ionic currents in human mesenchymal stem cells from bone marrow. Stem Cells 2005; 23: 371-382