Loss of epithelial membrane protein-2 expression confers an independent prognosticator in nasopharyngeal carcinoma: A cohort study

BMJ Open

Volumn 2, Issue 2, 2012, Pages

  Chen, Yi Hsien ^a   Wu, Li Ching ^a   Wu, Wen Ren ^b   Lin, Hung Jung ^a   Lee, Sung Wei ^a   Lin, Ching Yih ^a   Chang, Shih Lun ^a   Chow, Nan Haw ^c,d   Huang, Hsuan Ying ^e   Li, Chien Feng ^a,b,f,g   Hsu, Han Ping ^h   Shiue, Yow Ling ^b  

^a CHI MEI MEDICAL CENTER   (Taiwan)

^b NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^c NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

^d NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^e CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^f National Institute of Cancer Research   (Taiwan)

^g SOUTHERN TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^h CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

EPITHELIAL MEMBRANE PROTEIN 2; MEMBRANE PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER DIAGNOSIS; CANCER RECURRENCE; CANCER STAGING; CANCER SURVIVAL; COHORT ANALYSIS; DISEASE SPECIFIC SURVIVAL; DISTANT METASTASIS; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; NASOPHARYNX CARCINOMA; OUTCOME ASSESSMENT; PRACTICE GUIDELINE; PRIMARY TUMOR; PROGNOSIS; RETROSPECTIVE STUDY; TUMOR BIOPSY;

EID: 84860904596     PISSN: None     EISSN: 20446055     Source Type: Journal    
DOI: 10.1136/bmjopen-2012-000900     Document Type: Article

References (36)

1. Chang ET, Adami HO. The enigmatic epidemiology of nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev 2006;15:1765-77. (Pubitemid 44664247)
2. Yu MC, Yuan JM. Epidemiology of nasopharyngeal carcinoma. Semin Cancer Biol 2002;12:421-9. (Pubitemid 35370755)
3. Liebowitz D. Nasopharyngeal carcinoma: the Epstein-Barr virus association. Semin Oncol 1994;21:376-81. (Pubitemid 24191597)
4. Lo KW, To KF, Huang DP. Focus on nasopharyngeal carcinoma. Cancer Cell 2004;5:423-8. (Pubitemid 38612865)
5. Fang FM, Chien CY, Li CF, et al. Effect of S-phase kinase-associated protein 2 expression on distant metastasis and survival in nasopharyngeal carcinoma patients. Int J Radiat Oncol Biol Phys 2009;73:202-7.
6. Fang FM, Tsai WL, Go SF, et al. Implications of quantitative tumor and nodal regression rates for nasopharyngeal carcinomas after 45 Gy of radiotherapy. Int J Radiat Oncol Biol Phys 2001;50:961-9.
7. Jeyakumar A, Brickman TM, Doerr T. Review of nasopharyngeal carcinoma. Ear Nose Throat J 2006;85:168-70, 172-3, 184.
8. Ben-Porath I, Kozak CA, Benvenisty N. Chromosomal mapping of Tmp (Emp1), Xmp (Emp2), and Ymp (Emp3), genes encoding membrane proteins related to Pmp22. Genomics 1998;49:443-7. (Pubitemid 28268353)
9. Liehr T, Kuhlenbaumer G, Wulf P, et al. Regional localization of the human epithelial membrane protein genes 1, 2, and 3 (EMP1, EMP2, EMP3) to 12p12.3, 16p13.2, and 19q13.3. Genomics 1999;58:106-8. (Pubitemid 29269888)
10. Wang CX, Wadehra M, Fisk BC, et al. Epithelial membrane protein 2, a 4-transmembrane protein that suppresses B-cell lymphoma tumorigenicity. Blood 2001;97:3890-5.
11. Taylor V, Suter U. Epithelial membrane protein-2 and epithelial membrane protein-3: two novel members of the peripheral myelin protein 22 gene family. Gene 1996;175:115-20. (Pubitemid 26363007)
12. Berditchevski F, Odintsova E. Characterization of integrin-tetraspanin adhesion complexes: role of tetraspanins in integrin signaling. J Cell Biol 1999;146:477-92. (Pubitemid 29369782)
13. Jetten AM, Suter U. The peripheral myelin protein 22 and epithelial membrane protein family. Prog Nucleic Acid Res Mol Biol 2000;64:97-129.
14. Wadehra M, Sulur GG, Braun J, et al. Epithelial membrane protein-2 is expressed in discrete anatomical regions of the eye. Exp Mol Pathol 2003;74:106-12. (Pubitemid 36438658)
15. Kandouz M, Batist G. Gap junctions and connexins as therapeutic targets in cancer. Expert Opin Ther Targets 2010;14:681-92.
16. Wolden SL, Zelefsky MJ, Kraus DH, et al. Accelerated concomitant boost radiotherapy and chemotherapy for advanced nasopharyngeal carcinoma. J Clin Oncol 2001;19:1105-10. (Pubitemid 32176287)
17. Horikawa T, Yang J, Kondo S, et al. Twist and epithelial-mesenchymal transition are induced by the EBV oncoprotein latent membrane protein 1 and are associated with metastatic nasopharyngeal carcinoma. Cancer Res 2007;67:1970-8. (Pubitemid 46424213)
18. Wadehra M, Goodglick L, Braun J. The tetraspan protein EMP2 modulates the surface expression of caveolins and glycosylphosphatidyl inositol-linked proteins. Mol Biol Cell 2004;15:2073-83. (Pubitemid 38580629)
19. Wadehra M, Natarajan S, Seligson DB, et al. Expression of epithelial membrane protein-2 is associated with endometrial adenocarcinoma of unfavorable outcome. Cancer 2006;107:90-8. (Pubitemid 43939035)
20. Fu M, Maresh EL, Soslow RA, et al. Epithelial membrane protein-2 is a novel therapeutic target in ovarian cancer. Clin Cancer Res 2010;16:3954-63.
21. Habeeb O, Goodglick L, Soslow RA, et al. Epithelial membrane protein-2 expression is an early predictor of endometrial cancer development. Cancer 2010;116:4718-26.
22. Wadehra M, Iyer R, Goodglick L, et al. The tetraspan protein epithelial membrane protein-2 interacts with beta1 integrins and regulates adhesion. J Biol Chem 2002;277:41094-100. (Pubitemid 35215700)
23. Wadehra M, Forbes A, Pushkarna N, et al. Epithelial membrane protein-2 regulates surface expression of alphavbeta3 integrin in the endometrium. Dev Biol 2005;287:336-45. (Pubitemid 41636768)
24. Morales SA, Mareninov S, Coulam P, et al. Functional consequences of interactions between FAK and epithelial membrane protein 2 (EMP2). Invest Ophthalmol Vis Sci 2009;50:4949-56.
25. Chigaev A, Sklar LA. Overview: assays for studying integrin-dependent cell adhesion. Methods Mol Biol 2012;757:3-14.
26. Margadant C, Monsuur HN, Norman JC, et al. Mechanisms of integrin activation and trafficking. Curr Opin Cell Biol 2011;23:607-14.
27. Wadehra M, Su H, Gordon LK, et al. The tetraspan protein EMP2 increases surface expression of class I major histocompatibility complex proteins and susceptibility to CTL-mediated cell death. Clin Immunol 2003;107:129-36. (Pubitemid 36579377)
28. Wilson HL, Wilson SA, Surprenant A, et al. Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus. J Biol Chem 2002;277:34017-23.
29. Yuan JM, Wang XL, Xiang YB, et al. Preserved foods in relation to risk of nasopharyngeal carcinoma in Shanghai, China. Int J Cancer 2000;85:358-63.
30. Lo KW, Huang DP. Genetic and epigenetic changes in nasopharyngeal carcinoma. Semin Cancer Biol 2002;12:451-62. (Pubitemid 35370758)
31. Razak AR, Siu LL, Liu FF, et al. Nasopharyngeal carcinoma: the next challenges. Eur J Cancer 2010;46:1967-78.
32. Lee AW, Sze WM, Au JS, et al. Treatment results for nasopharyngeal carcinoma in the modern era: the Hong Kong experience. Int J Radiat Oncol Biol Phys 2005;61:1107-16. (Pubitemid 40340904)
33. Guigay J. Advances in nasopharyngeal carcinoma. Curr Opin Oncol 2008;20:264-9. (Pubitemid 351507545)
34. Xu HM, Liang Y, Chen Q, et al. Correlation of Skp2 overexpression to prognosis of patients with nasopharyngeal carcinoma from South China. Chin J Cancer 2011;30:204-12.
35. Cao XJ, Hao JF, Yang XH, et al. Prognostic value of expression of EGFR and nm23 for locoregionally advanced nasopharyngeal carcinoma. Med Oncol 2011;2011:8.
36. Lee AW, Tung SY, Ngan RK, et al. Factors contributing to the efficacy of concurrent-adjuvant chemotherapy for locoregionally advanced nasopharyngeal carcinoma: combined analyses of NPC-9901 and NPC-9902 Trials. Eur J Cancer 2011;47:656-66.