Correlation of skp2 overexpression to prognosis of patients with nasopharyngeal carcinoma from South China

Chinese Journal of Cancer

Volumn 30, Issue 3, 2011, Pages 204-212

  Xu, Hui Min ^a   Liang, Yi ^a   Chen, Qiong ^a   Wu, Qi Nian ^a   Guo, Yun Miao ^a   Shen, Guo Ping ^a   Zhang, Ru Hua ^a   He, Zhi Wei ^b   Zeng, Yi Xin ^a   Xie, Fang Yun ^a   Kang, Tie Bang ^a  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^b GUANGDONG MEDICAL UNIVERSITY   (China)

Author keywords

Cancer stem cells (CSCS); Nasopharyngeal neoplasm; Prognosis; S phase kinase associated protein 2 (Skp2); Side population (SP)

Indexed keywords

ANTINEOPLASTIC AGENT; S PHASE KINASE ASSOCIATED PROTEIN 2;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER CELL CULTURE; CANCER RADIOTHERAPY; CANCER STAGING; CANCER STEM CELL; CELL RENEWAL; CHEMORADIOTHERAPY; CHINA; COLONY FORMATION; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; NASOPHARYNX CARCINOMA; OVERALL SURVIVAL; PHENOTYPE; PREDICTION; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEX; SIDE POPULATION CELL;

EID: 79954550937     PISSN: 1000467X     EISSN: 1944446X     Source Type: Journal    
DOI: 10.5732/cjc.010.10403     Document Type: Article

References (17)

1. Ji P, Goldin L, Ren H, et al. Skp2 contains a novel cyclln a binding domain that directly protects cyclln a from Inhibition by p27klp1 [J]. J Biol Chem, 2006,281(33):24058-24069.
2. Hershko DD. Oncogenlc properties and prognostic Implications of the ublqultln ligase skp2 In cancer [J]. Cancer, 2008,112(7):1415-1424
3. Reya T, Morrison SJ, Clarke MF, et al. Stem cells, cancer, and cancer stem cells [J]. Nature, 2001,414(6859):105-111
4. Houghton J, Morozov A, Smlrnova I, et al. Stem cells and cancer [J]. Semln Cancer Biol, 2007,17(3):191-203
5. Zhou S, Schuetz JD, Bunting KD, et al. The abc transporter bcrp1/abcg2 Is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype [J]. Nat Med, 2001,7(9):1028-1034
6. Schatton T, Murphy GF, Frank NY, et al. Identification of cells Initiating human melanomas [J]. Nature, 2008,451 (7176):345-349
7. Mani SA, Guo W, Llao MJ, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells [J]. Cell, 2008,133(4):704-715
8. 4 cancer stem cells with metastatic capacity in human colorectal cancer [J]. Cell Stem Cell, 2010,6(6):603-615
9. Glnestier C, Hur MH, Charafe-Jauffret E, et al. Aldhi ¡s a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome [J]. Cell Stem Cell, 2007,1(5):555-567.
10. 4 cells Is associated with poor prognosis In colon carcinoma patients with stage 1Mb [J]. J Transi Med, 2009,7:56
11. Hirschmann-Jax C, Foster AE, Wulf GG, et al. A distinct Side population Of cells with high drug efflux capacity In human tumor cells [J]. Proc Nati Acad Sei USA, 2004,101 (39):14228-14233.
12. Haraguchl N, Utsunomlya T, Inoue H, et al. Characterization of a side population of cancer cells from human gastrointestinal system [J]. Stem Cells, 2006,24(3):506-513
13. Wang J, Guo LP, Chen LZ, et al. Identification of cancer stem cell-like side population cells In human nasopharyngeal carcinoma cell line [J]. Cancer Res, 2007,67(8):3716-3724.
14. Liang Y, Zhong Z, Huang Y, et al. Stem-like cancer cells are inducible by increasing genomic Instability In cancer cells [J]. J Biol Chem, 2010,285(7):4931-4940
15. Lee SH, Lee JK, Jin SM, et al. Expression of cell-cycle regulators (cyclln d1, cyclin e, p27klp1, p57kip2) In papillary thyroid carcinoma [J]. Otolaryngol Head Neck Surg, 2010,142 (3):332-337
16. Fang FM, Chlen CY, Li CF, et al. Effect of S-phase kinase associated protein 2 expression on distant metastasis and survival In nasopharyngeal carcinoma patients [J]. Int J Radiat Oncol Biol Phys, 2009,73(1):202-207
17. Gupta PB, Onder TT, Jiang G, et al. Identification of selective Inhibitors of cancer stem cells by high-throughput screening [J]. Cell, 2009,138(4):645-659.