Highly efficient method of preparing human catalytic antibody light chains and their biological characteristics

FASEB Journal

Volumn 26, Issue 4, 2012, Pages 1607-1615

  Hifumi, Emi ^a,c   Honjo, Eijiro ^a,c   Fujimoto, Naoko ^a,c   Arakawa, Mitsue ^a,c   Nishizono, Akira ^b,c   Uda, Taizo ^a,c  

^a OITA UNIVERSITY   (Japan)

^b OITA UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Germline gene; Infection; Rabies virus

Indexed keywords

ASPARTIC ACID; CATALYTIC ANTIBODY; DNA; DNA FRAGMENT; HISTIDINE; SERINE; SERINE PROTEINASE; SYNTHETIC PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLONE; CONTROLLED STUDY; DNA LIBRARY; DRUG EFFICACY; ESCHERICHIA COLI; GENE EXPRESSION; GERM LINE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; INOCULATION; LETHALITY; LIGHT CHAIN; MOLECULAR CLONING; MOUSE; NONHUMAN; NORMAL HUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROCEDURES; PURIFICATION; RABIES VIRUS; SURVIVAL RATE; VIRUS INFECTIVITY; VIRUS INHIBITION;

ALGORITHMS; AMINO ACID SEQUENCE; ANIMALS; ANIMALS, SUCKLING; ANTIBODIES, CATALYTIC; DNA; GERM CELLS; HUMANS; IMMUNOGLOBULIN LIGHT CHAINS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; POLYMERASE CHAIN REACTION; PROTEIN CONFORMATION; RABIES VIRUS; SEQUENCE ALIGNMENT; SURVIVAL RATE;

ESCHERICHIA COLI; MUS; RABIES VIRUS;

EID: 84860903184     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.11-195339     Document Type: Article

References (27)

1. Lerner, R. A., Benkovic, S. J., and Schultz, P. G. (1991) At the crossroads of chemistry and immunology: catalytic antibodies. Science 252, 659-667 (Pubitemid 21916986)
2. Mei, S., Mody, B., Eklund, S. H., and Paul, S. (1991) Vasoactive intestinal peptide hydrolysis by antibody light chains (Communication). J. Biol. Chem. 266, 15571-15574 (Pubitemid 21907689)
3. Shuster, A. M., Gololobov, G. V., Kvashuk, O. A., Bogomolova, A. E., Smirnov, I. V., and Gabibov, A. G. (1992) DNA hydrolyzing autoantibodies. Science 256, 665-667
4. Hifumi, E., Mitsuda, Y., Ohara, K., and Uda, T. (2002) Targeted destruction of the HIV-1 coat protein gp41 by a catalytic antibody light chain. J. Immunol. Methods 269, 283-298
5. Paul, S., Karle, S., Planque, S., Taguchi, H., Nishiyama, Y., Handy, B., Salas, M., Edmundson, A., and Hanson, A. (2004) Naturally occurring proteolytic antibodies: selective immunoglobulin M-catalyzed hydrolysis of HIV gp120. J. Biol. Chem. 279, 39611-39619 (Pubitemid 39258228)
6. Lacroix-Desmazes, S., Moreau, A., Sooryanarayana, Bonnemain, C., Stieltjes, N., Pashov, A., Sultan, Y., Hoebeke, J., Kazatchkine, M. D., and Kaveri, S. V. (1999) Catalytic activity of antibodies against factor VIII in patients with hemophilia A. Nat. Med. 5, 1044-10470
7. Hifumi, E., Morihara, F., Hatiuchi, K., Okuda, T., Nishizono, A., and Uda, T. (2008) Catalytic features and eradication ability of antibody light-chain UA15-L against. Helicobacter pylori. J. Biol. Chem. 283, 899-907
8. Gololobov, G., Sun, M., and Paul, S. (1999) Innate antibody catalysis. Mol. Immunol. 36, 1215-1222 (Pubitemid 30137202)
9. Hifumi, E., Higashi, K., and Uda, T. (2010) Catalytic digestion of human tumor necrosis factor-α by antibody heavy chain. FEBS J. 277, 3823-3832
10. Uda, T., and Hifumi, E. (2004) Super catalytic antibody and antigenase. J. Biosci. Bioeng. 97, 143-152 (Pubitemid 38457109)
11. Ramsland, R. A., Terzyan, S. S., Cloud, G., Bourne, C. R., Farrugia, W., Tribbick, G., Geysen, H. M., Moomaw, C. R., Slaughter, C. A., and Edmundson, A. B. (2006) Crystal structure of a glycosylated Fab from an IgM cryoglobulin with properties of a natural proteolytic antibody. Biochem. J. 396, 473-481
12. Anchin, J. M., Mandal, C., Culberson, C., Subramaniam, S., and Linthicum, D. S. (1994) Computer-aided molecular modeling of the binding site architecture for eight monoclonal antibodies that bind a high potency guanidine sweetener. J. Mol. Graph. 12, 257-266
13. Smith, J., Yager, P., and Baer, G. (1973) A rapid reproducible test for determining rabies neutralizing antibody. Bull. World. Health. Org. 48, 535-541
14. Matsumoto, T., Yamada, K., Noguchi, K., Nakajima, K., Takada, K., Khawplod, P., and Nishizono, A. (2010) Isolation and characterization of novel human monoclonal antibodies possessing neutralizing ability against rabies virus. Microbiol. Immunol. 54, 673-683
15. Hatiuchi, K., Hifumi, E., Mitsuda, Y., and Uda, T. (2003) Endopeptidase character of monoclonal antibody i41-7 subunits. Immunol. Lett. 86, 249-257 (Pubitemid 36428684)
16. Mitsuda, Y., Hifumi, E., Tsuruhata, K., Fujinami, H., Yamamoto, N., and Uda, T. (2004) Catalytic antibody light chain capable of cleaving a chemokine receptor CCR-5 peptide with a high reaction rate constant. Biotechnol. Bioeng. 86, 217-225 (Pubitemid 38419634)
17. Lautner-Rieske, A., Huber, C., Meindl, A., Pargent, W., Schäble, K. F., Thiebe, R., Zocher, I., and Zachau, H. G. (1992) The human immunoglobulin kappa locus. Characterization of the duplicated A regions. Eur. J. Immunol. 22, 1023-1029
18. Gao, Q. S., Sun, M., Tyutyukova, S., Webster, D., Rees, A., Tramontano, A., Massey, R. J., and Paul, S. (1994) Molecular cloning of a proteolytic antibody light chain. J. Biol. Chem. 269, 32389-32393
19. Hifumi, E., Okamoto, Y., and Uda, T. (2000) How and why 41S-2 antibody subunits acquire the ability to catalyze decomposition of the conserved sequence of gp41 of HIV-1. Biochem. Biotechnol. 83, 209-220 (Pubitemid 30337389)
20. Sun, M., Gao, Q. S., Li, L., and Paul, S. (1994) Proteolytic activity of an antibody light chain. J. Immunol. 153, 5121-5126 (Pubitemid 24356142)
21. Okochi, N., Kato-Murai, M., Kadonosono, T., and Ueda, M. (2007) Design of a serine protease-like catalytic triad on an antibody light chain displayed on the yeast cell surface. Appl. Microbiol. Biotech. 77, 597-603 (Pubitemid 350125512)
22. Gao, Q. S., Sun, M., Rees, A. R., and Paul, S. (1995) Site-directed mutagenesis of proteolytic antibody light chain. J. Mol. Biol. 253, 658-664
23. Kolesnikov, A. V., Kozyr, A. V., Alexandrova, E. S., Koralewski, F., Demin, A. V., Titov, M. I., Avalle, B., Tramontano, A., Paul, S., Thomas, D., Gabibov, A. G., and Friboulet, A. (2000) Enzyme mimicry by the antiidiotypic antibody approach. Proc. Natl. Acad. Sci. U. S. A. 97, 13526-13531
24. Hollfelder, F., Kirby, A. J., Tawfik, D. S. (1996) Off the shelf proteins that rival tailor-made antibodies as catalysts. Nature 383, 60-63 (Pubitemid 26296457)
25. Sharma, V., Heriot, W., Trisler, K., and Smider, V. (2009) A human germ line antibody light chain with hydrolytic properties associated its multimerization status. J. Biol. Chem. 284, 33079-33087
26. Planque, S., Nishiyama, Y., Taguchi, H., Salas, M., Hanson, C., and Paul, S. (2008) Catalytic antibodies to HIV: physiological role and potential clinical utility. Autoimmun. Rev. 7, 473-479
27. Paul, S., Planque, S., and Nishiyama, Y. (2010) Immunological origin and functional properties of catalytic autoantibodies to amyloid peptide. J. Clin. Immunol. 30, S43-S49