N-glycan cryptic antigens as active immunological targets in prostate cancer patients

Journal of Proteomics and Bioinformatics

Volumn 5, Issue 4, 2012, Pages 90-95

  Wang, Denong ^a  

^a SRI INTERNATIONAL   (United States)

Author keywords

Autoantibodies; Carbohydrate microarrays; Cryptic antigens; Oligomannose; Prostate cancer; Tumor glycomics

Indexed keywords

AUTOANTIGEN; CARBOHYDRATE ANTIGEN; GLYCAN; IMMUNOGLOBULIN G ANTIBODY; MANNOSE;

ANTIBODY BLOOD LEVEL; ANTIBODY RESPONSE; ANTIGEN DETECTION; ANTIGEN EXPRESSION; ANTIGEN RECOGNITION; ARTICLE; CANCER PATIENT; CARBOHYDRATE ANALYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; MALE; MICROARRAY ANALYSIS; PROSTATE CANCER; PROSTATE HYPERTROPHY; PROTEIN TARGETING;

ALOSINAE; HUMAN IMMUNODEFICIENCY VIRUS 1; SARS CORONAVIRUS;

EID: 84860893082     PISSN: None     EISSN: 0974276X     Source Type: Journal    
DOI: 10.4172/jpb.1000218     Document Type: Article

References (39)

1. Prakash S, Robbins PW (2000) Glycotyping of prostate specific antigen. Glycobiology 10: 173-176.
2. Peracaula R, Tabares G, Royle L, Harvey DJ, Dwek RA, et al. (2003) Altered glycosylation pattern allows the distinction between prostate-specific antigen (PSA) from normal and tumor origins. Glycobiology 13: 457-470.
3. Ohyama C, Hosono M, Nitta K, Oh-eda M, Yoshikawa K, et al. (2004) Carbohydrate structure and differential binding of prostate specific antigen to Maackia amurensis lectin between prostate cancer and benign prostate hypertrophy. Glycobiology 14: 671-679.
4. Palma AS, Liu Y, Childs RA, Herbert C, Wang D, et al. (2011) The human epithelial carcinoma antigen recognized by monoclonal antibody AE3 is expressed on a sulfoglycolipid in addition to neoplastic mucins. Biochem Biophys Res Commun 408: 548-552.
5. Abel PD, Marsh C, Henderson D, Leathem A, Powell PH, et al. (1987) Detection of blood group antigens in frozen sections of prostatic epithelium. Br J Urol 59: 430-435.
6. Satoh M, Fukushi Y, Kawamura S, Ohyama C, Saito S, et al. (1992) Glycolipid expression in prostatic tissue and analysis of the antigen recognized by antiprostatic monoclonal antibody APG1. Urol Int. 48: 20-24.
7. Moriyama H, Nakano H, Igawa M, Nihira H (1987) T antigen expression in benign hyperplasia and adenocarcinoma of the prostate. Urol Int 42: 120-123.
8. Ghazizadeh M, Kagawa S, Izumi K, Kurokawa K (1984) Immunohistochemical localization of T antigen-like substance in benign hyperplasia and adenocarcinoma of the prostate. J Urol 132: 1127-1130.
9. Zhang S, Zhang HS, Reuter VE, Slovin SF, Scher HI, et al. (1998) Expression of potential target antigens for immunotherapy on primary and metastatic prostate cancers. Clin Cancer Res 4: 295-302.
10. Chandrasekaran EV, Xue J, Xia J, Chawda R, Piskorz C, et al. (2005) Analysis of the specificity of sialyltransferases toward mucin core 2, globo, and related structures. identification of the sialylation sequence and the effects of sulfate, fucose, methyl, and fluoro substituents of the carbohydrate chain in the biosynthesis of selectin and siglec ligands, and novel sialylation by cloned alpha2,3(O)sialyltransferase. Biochemistry 44: 15619-15635.
11. Abel PD, Cornell C, Buamah PK, Williams G (1987) Assessment of serum CA 19.9 as a tumour marker in patients with carcinoma of the bladder and prostate. Br J Urol 59: 427-429.
12. Jorgensen T, Berner A, Kaalhus O, Tveter KJ, Danielsen HE, et al. (1995) Upregulation of the oligosaccharide sialyl LewisX: a new prognostic parameter in metastatic prostate cancer. Cancer Res 55: 1817-1819.
13. Wandall HH, Blixt O, Tarp MA, Pedersen JW, Bennett EP, et al. (2010) Cancer biomarkers defined by autoantibody signatures to aberrant O-glycopeptide epitopes. Cancer Res 70: 1306-1313.
14. Blixt O, Bueti D, Burford B, Allen D, Julien S, et al. (2011) Autoantibodies to aberrantly glycosylated MUC1 in early stage breast cancer are associated with a better prognosis. Breast Cancer Res 13: R25.
15. Padler-Karavani V, Hurtado-Ziola N, Pu M, Yu H, Huang S, et al. (2011) Human xeno-autoantibodies against a non-human sialic acid serve as novel serum biomarkers and immunotherapeutics in cancer. Cancer Res. 71: 3352-3363.
16. Wang D, Herzenberg LA, Peehl D, Herzenberg LA (2011) Prostate cancer glycan markers and auto-antibody signatures. Assigned to The Board of Trustees of the Leland Stanford Junior University, U.S. Patent No. 7,981,625. July 19, 2011.
17. Lange T, Ullrich S, Muller I, Nentwich MF, Stubke K, et al. (2012) Human prostate cancer in a clinically relevant xenograft mouse model: identification of beta(1,6)-branched oligosaccharides as a marker of tumor progression. Clin Cancer Res 18: 1384.
18. Handerson T, Pawelek JM (2003) Beta1,6-branched oligosaccharides and coarse vesicles: a common, pervasive phenotype in melanoma and other human cancers. Cancer Res 63: 5363-5369.
19. Trkola A, Purtscher M, Muster T, Ballaun C, Buchacher A, et al. (1996) Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1. J Virol 70: 1100-1108.
20. Scanlan CN, Pantophlet R, Wormald MR, Ollmann Saphire E, Stanfield R et al. (2002) The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1-->2 mannose residues on the outer face of gp120. J Virol 76: 7306-7321.
21. Wang D, Lu J (2004) Glycan arrays lead to the discovery of autoimmunogenic activity of SARS-CoV. Physiol Genomics 18: 245-248.
22. Wang D, Herzenberg LA (2011) Glycan markers and auto-antibody signatures in HIV-1 and HIV-1-associated malignancies. Assignee: The Board of Trustees of the Leland Stanford Junior University, Patent application No. 20110177090, Files Jan 19, 2011.
23. Sanders RW, Venturi M, Schiffner L, Kalyanaraman R, Katinger H, et al. (2002) The mannose-dependent epitope for neutralizing antibody 2G12 on human immunodeficiency virus type 1 glycoprotein gp120. J Virol 76: 7293-7305.
24. Wang D, Newsom-Davis TE, Steinman L, Chen PF, Wang LX, et al. (2009) Enhanced immune recognition of cryptic glycan markers in human tumors. Cancer Res 69: 2018-2025.
25. Wang LX, Ni J, Singh S, Li H (2004) Binding of high-mannose-type oligosaccharides and synthetic oligomannose clusters to human antibody 2G12: implications for HIV-1 vaccine design. Chem Biol 11: 127-134.
26. Wang LX (2006) Toward oligosaccharide-and glycopeptide-based HIV vaccines. Curr Opin Drug Discov Devel 9: 194-206.
27. Ni J, Song H, Wang Y, Stamatos NM, Wang LX (2006) Toward a carbohydratebased HIV-1 vaccine: synthesis and immunological studies of oligomannosecontaining glycoconjugates. Bioconjug Chem 17: 493-500.
28. Li H, Wang LX (2004) Design and synthesis of a template-assembled oligomannose cluster as an epitope mimic for human HIV-neutralizing antibody 2G12. Org Biomol Chem 2: 483-488.
29. Wang D, Herzenberg LA, Steinman L (2005) A lipid-based microarray and methods of use thereof. PCT International application No. PCT/US2006/011544, claiming benefit of U.S. Provisional Application No. 60/664,251.
30. Wang D, Liu S, Trummer BJ, Deng C, Wang A (2002) Carbohydrate microarrays for the recognition of cross-reactive molecular markers of microbes and host cells. Nat Biotechnol 20: 275-281.
31. Liu Y, Childs RA, Palma AS, Campanero-Rhodes MA, Stoll MS, et al. (2012) Neoglycolipid-based oligosaccharide microarray system: preparation of NGLs and their noncovalent immobilization on nitrocellulose-coated glass slides for microarray analyses. Methods Mol Biol 808: 117-136.
32. Wang D (2012) Carbohydrate antigen microarrays. Methods Mol Biol 808: 241-249.
33. Wang D, Kabat EA (1998) Antibodies, Specificity. In: Encyclopedia of Immunology, Edn. Second (ed. Delves & Roitt) 148-154.
34. Wang D, Wells SM, Stall AM, Kabat EA (1994) Reaction of germinal centers in the T-cell-independent response to the bacterial polysaccharide alpha(1-->6) dextran. Proc Natl Acad Sci U S A 91: 2502-2506.
35. Wang D, Liao J, Mitra D, Akolkar PN, Gruezo F (1991) The repertoire of antibodies to a single antigenic determinant. Mol Immunol 28: 1387-1397.
36. Seidl KJ, MacKenzie JD, Wang D, Kantor AB, Kabat EA, et al. (1997) Recurrent identical rearrangement and repeated expression of identical heavy and light chains in single anti-phosphatidylcholine B cells. Ann N Y Acad Sci 815: 484-488.
37. Seidl KJ, MacKenzie JD, Wang D, Kantor AB, Kabat EA, et al. (1997) Frequent occurrence of identical heavy and light chain Ig rearrangements. Int Immunol 9: 689-702.
38. Smith K, Garman L, Wrammert J, Zheng NY, Capra JD, et al. (2009) Rapid generation of fully human monoclonal antibodies specific to a vaccinating antigen. Nat Protoc 4: 372-384.
39. Lau KS, Dennis JW (2008) N-Glycans in cancer progression. Glycobiology 18: 750-760.