Apoptotic cells can deliver chemotherapeutics to engulfing macrophages and suppress inflammatory cytokine production

Journal of Biological Chemistry

Volumn 287, Issue 19, 2012, Pages 16029-16036

  Perez, Beatriz ^a,b   Paquette, Nicholas ^a   Païdassi, Helena ^a,c   Zhai, Bo ^a,d   White, Kristin ^a   Skvirsky, Rachel ^b   Lacy Hulbert, Adam ^a   Stuart, Lynda M ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF MASSACHUSETTS BOSTON   (United States)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTINOMYCIN D; ANTI-TUMORS; APOPTOTIC; APOPTOTIC CELLS; CASPASES; CELL LINES; CELL-CELL CONTACT; CHEMOTHERAPEUTIC AGENTS; CYTOKINE PRODUCTION; CYTOTOXIC DRUGS; DIFFERENT MECHANISMS; ETOPOSIDE; JURKAT CELL; PRIMARY CELLS; TROJAN HORSE;

ANTIGEN-ANTIBODY REACTIONS; CELL CULTURE; CELL DEATH; DRUG THERAPY;

MACROPHAGES;

CASPASE; DACTINOMYCIN; ETOPOSIDE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CONTACT; CHEMOTHERAPY; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REPRESSION; LEUKEMIA CELL LINE; MACROPHAGE; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN INTERACTION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL COMMUNICATION; CELL LINE; COCULTURE TECHNIQUES; CYTOKINES; DACTINOMYCIN; ETOPOSIDE; FLOW CYTOMETRY; HUMANS; INFLAMMATION MEDIATORS; JURKAT CELLS; LIPOPOLYSACCHARIDES; MACROPHAGES; PHAGOCYTOSIS; TUMOR NECROSIS FACTOR-ALPHA;

EQUIDAE;

EID: 84860866631     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.340489     Document Type: Article

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