The protective mechanism for the blood-brain barrier induced by aminoguanidine in surgical brain injury in rats

Cellular and Molecular Neurobiology

Volumn 31, Issue 8, 2011, Pages 1213-1219

  Fan, Di ^a,b   Gu, Yan Ting ^c   Lv, Hui ^d   Tang, Tao ^b   Xu, Zai Hua ^b   Song, Zhen Quan ^b   Tong, Xiao Jie ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b GENERAL HOSPITAL OF NORTHERN THEATER COMMAND   (China)

^c SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^d Shenyang Stomatology Hospital   (China)

Author keywords

Aminoguanidine; BBB; Surgical brain injury; Tight junction

Indexed keywords

AMINOGUANIDINE; ANTIOXIDANT; EVANS BLUE; GLUTATHIONE; INDUCIBLE NITRIC OXIDE SYNTHASE; MALONALDEHYDE; PROTEIN ZO1; TIGHT JUNCTION PROTEIN; GUANIDINE DERIVATIVE; MEMBRANE PROTEIN; PHOSPHOPROTEIN; ZONULA OCCLUDENS-1 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN INJURY; BRAIN TISSUE; CONTROLLED STUDY; CORRELATIONAL STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; EXTRAVASATION; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; SURGICAL BRAIN INJURY; SURGICAL INJURY; TREATMENT DURATION; UPREGULATION; ANIMAL; HUMAN; METABOLISM; PATHOLOGY; PERMEABILITY; PHYSIOLOGY; RANDOMIZATION; SPRAGUE DAWLEY RAT;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN INJURIES; GLUTATHIONE; GUANIDINES; HUMANS; MALE; MALONDIALDEHYDE; MEMBRANE PROTEINS; NITRIC OXIDE SYNTHASE TYPE II; PERMEABILITY; PHOSPHOPROTEINS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84860860482     PISSN: 02724340     EISSN: 15736830     Source Type: Journal    
DOI: 10.1007/s10571-011-9723-0     Document Type: Article

References (28)

1. Abbott NJ, Patabendige AA, Dolman DE, Yusof SR, Begley DJ (2010) Structure and function of the blood-brain barrier. Neurobiol Dis 37(1):13-25
2. Blyth BJ, Farhavar A, Gee C, Hawthorn B, He H, Nayak A, Stöcklein V, Bazarian JJ (2009) Validation of serum markers for blood- brain barrier disruption in traumatic brain injury. J Neurotrauma 26(9):1497-1507
3. Chowdhury P, Soulsby ME, Scott JL (2009) Effects of aminoguanidine on tissue oxidative stress induced by hindlimb unloading in rats. Ann Clin Lab Sci 39(1):64-70
4. Di Naso FC, Forgiarini LA Jr, Forgiarini LF, Porawski M, Dias AS, Marroni NA (2010) Aminoguanidine reduces oxidative stress and structural lung changes in experimental diabetes mellitus. J Bras Pneumol 36(4):485-489
5. Di F, Yan-Ting G, Hui L, Tao T, Zai-Hua X, Xue-Ying S, Hong-Li X, Yun-Jie W (2008) Role of aminoguanidine in brain protection in surgical brain injury in rat. Neurosci Lett 448(2):204-207
6. Fanning AS, Anderson JM (2009) Zonula occludens-1 and -2 are cytosolic scaffolds that regulate the assembly of cellular junctions. Ann N Y Acad Sci 1165:113-120
7. Furuse M (2010) Molecular basis of the core structure of tight junctions. Cold Spring Harb Perspect Biol 2(1):a002907
8. Guan Y, Watson AJ, Marchiando AM, Bradford EM, Shen L, Turner JR, Montrose MH (2011) Redistribution of the tight junction protein ZO-1 during physiologic shedding of mouse intestinal epithelial cells. Am J Physiol Cell Physiol 300(6):C1404-C1414
9. Gül N, Bögels M, Grewal S, van der Meer AJ, Baldeon Rojas L, Fluitsma DM, van den Tol MP, Hoeben KA, van Marle J, de Vries HE, Beelen RH, van Egmond M (2011) Surgery-induced reactive oxygen species enhance colon carcinoma cell binding by disrupting the liver endothelial cell lining. Gut [Epub ahead of print]
10. Haorah J, Schall K, Ramirez SH, Persidsky Y (2008) Activation of protein tyrosine kinases and matrix metalloproteinases causes blood-brain barrier injury: novel mechanism for neurodegeneration associated with alcohol abuse. Glia 56(1):78-88
11. Harhaj NS, Antonetti DA (2004) Regulation of tight junctions and loss of barrier function in pathophysiology. Int J Biochem Cell Biol 36(7):1206-1237
12. Huppert J, Closhen D, Croxford A, White R, Kulig P, Pietrowski E, Bechmann I, Becher B, Luhmann HJ, Waisman A, Kuhlmann CR (2010) Cellular mechanisms of IL-17-induced blood-brain barrier disruption. FASEB J 24(4):1023-1034
13. Jadhav V, Matchett G, Hsu FP, Zhang JH (2007) Inhibition of Src tyrosine kinase and effect on outcomes in a new in vivo model of surgically induced brain injury. J Neurosurg 106:680-686
14. Jadhav V, Ostrowski RP, Tong W, Matus B, Chang C, Zhang JH (2010) Hyperbaric oxygen preconditioning reduces postoperative brain edema and improves neurological outcomes after surgical brain injury. Acta Neurochir Suppl 106:217-220
15. Jiao H, Wang Z, Liu Y, Wang P, Xue Y (2011) Specific role of tight junction proteins claudin-5, occludin, and ZO-1 of the blood- brain barrier in a focal cerebral ischemic insult. J Mol Neurosci44(2):130-139
16. Korhonen R, Lahti A, Kankaanranta H, Moilanen E (2005) Nitric oxide production and signaling in inflammation. Curr Drug Targets Inflamm Allergy 4(4):471-479
17. Lee NP, Cheng CY (2003) Regulation of sertoli cell tight junction dynamics in the rat testis via the nitric oxide synthase/soluble guanylate cyclase/30,50-cyclic guanosine monophosphate/protein kinase G signaling pathway: an in vitro study. Endocrinology 144(7):3114-3129
18. Lee NP, Cheng CY (2004) Nitric oxide/nitric oxide synthase, spermatogenesis, and tight junction dynamics. Biol Reprod 70(2):267-276
19. Lee NPY, Yeung WSB, Luk JM (2007) Junction interaction in the seminiferous epithelium: regulatory roles of connexin-based gap junction. Front Biosci 12:1552-1562
20. Lo W, Bravo T, Jadhav V, Titova E, Zhang JH, Tang J (2007) NADPH oxidase inhibition improves neurological outcomes in surgically-induced brain injury. Neurosci Lett 414(3):228-232
21. Pluta RM, Rak R, Wink DA, Woodward JJ, Khaldi A, Oldfield EH, Watson JC (2001) Effects of nitric oxide on reactive oxygen species production and infarction size after brain reperfusion injury. Neurosurgery 48(4):884-892
22. Polat A, Parlakpinar H, Tasdemir S, Colak C, Vardi N, Ucar M, Emre MH, Acet A (2006) Protective role of aminoguanidine on gentamicin-induced acute renal failure in rats. Acta Histochem 108(5):365-371
23. Pottiez G, Flahaut C, Cecchelli R, Karamanos Y (2009) Understanding the blood-brain barrier using gene and protein expression profiling technologies. Brain Res Rev 62(1):83-98
24. Pun PB, Lu J, Moochhala S (2009) Involvement of ROS in BBB dysfunction. Free Radic Res 43(4):348-364
25. Schreibelt G, Musters RJP, Reijerkerk A, de Groot LR, van der Pol SMA, Hendrikx EML, Döpp ED, Dijkstra CD, Drukarch B, de Vries HE (2006) Lipoic acid affects cellular migration into the central nervous system and stabilizes blood-brain barrier integrity. J Immunol 177(4):2630-2637
26. Sun M, Zhao Y, Gu Y, Xu C (2010) Neuroprotective actions of aminoguanidine involve reduced the activation of calpain and caspase-3 in a rat model of stroke. Neurochem Int 56(4):634-641
27. Vermeulen NPE, Baldew GS (1992) The role of lipid peroxidation in the nephrotoxicity of cisplatin. Biochem Pharmacol 44:1193-1199
28. Yeh DY, Feng NH, Chen CF, Lin HI, Wang D (2008) Inducible nitric oxide synthase expressions in different lung injury models and the protective effect of aminoguanidine. Transplant Proc 40(7):2178-2181