Inhibition of Src tyrosine kinase and effect on outcomes in a new in vivo model of surgically induced brain injury

Journal of Neurosurgery

Volumn 106, Issue 4, 2007, Pages 680-686

  Jadhav, Vikram ^a   Matchett, Gerald ^a   Hsu, Frank P K ^a   Zhang, John H ^a,b  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LOMA LINDA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Brain edema; Brain injury; Neuroprotection; Rat; Tyrosine kinase inhibitor

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 METHYLPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; EVANS BLUE; IMMUNOGLOBULIN G; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN TYROSINE KINASE; PROTEIN ZO1; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BODY WEIGHT; BRAIN EDEMA; BRAIN INJURY; BRAIN SURGERY; BRAIN WATER; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DRUG INHIBITION; EXTRAVASATION; FRONTAL LOBE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MALE; MORTALITY; NEUROPROTECTION; NONHUMAN; OUTCOME ASSESSMENT; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; WESTERN BLOTTING;

ANIMALS; BRAIN EDEMA; BRAIN INJURIES; DISEASE MODELS, ANIMAL; MALE; NEUROSURGICAL PROCEDURES; PYRAZOLES; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; SRC-FAMILY KINASES; TREATMENT OUTCOME;

EID: 34047203302     PISSN: 00223085     EISSN: 00223085     Source Type: Journal    
DOI: 10.3171/jns.2007.106.4.680     Document Type: Article

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