Structural rearrangements of the central region of the morbillivirus attachment protein stalk domain trigger F protein refolding for membrane fusion

Journal of Biological Chemistry

Volumn 287, Issue 20, 2012, Pages 16324-16334

  Ader, Nadine ^a   Brindley, Melinda A ^b   Avila, Mislay ^a   Origgi, Francesco C ^a   Langedijk, Johannes P M ^d   Örvell, Claes ^e   Vandevelde, Marc ^a   Zurbriggen, Andreas ^a   Plemper, Richard K ^b,c   Plattet, Philippe ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CHILDREN'S HEALTHCARE OF ATLANTA   (United States)

^d CRUCELL HOLLAND BV   (Netherlands)

^e KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONAL CHANGE; CROSSLINKS; ECTODOMAIN; INTERMOLECULAR DISULFIDE BOND; MEMBRANE FUSION; PROTEIN REFOLDING; RECEPTOR BINDING; REDUCING CONDITIONS; STRUCTURAL REARRANGEMENT; SUBDOMAIN;

CELL MEMBRANES; COVALENT BONDS; OLIGOMERS;

PROTEINS;

H STALK DOMAIN PROTEIN; UNCLASSIFIED DRUG; VIRUS FUSION PROTEIN;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DISULFIDE BOND; MEASLES VIRUS; MEMBRANE FUSION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CROSS LINKING; PROTEIN ENGINEERING; PROTEIN EXPRESSION; PROTEIN REFOLDING; PROTEIN STRUCTURE; PROTEIN SUBUNIT; RECEPTOR BINDING; SEQUENCE HOMOLOGY; VIRUS STRAIN; VIRUS VIRULENCE;

ANIMALS; CERCOPITHECUS AETHIOPS; HUMANS; MEMBRANE FUSION; MORBILLIVIRUS; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; VERO CELLS; VIRAL FUSION PROTEINS; VIRUS INTERNALIZATION;

MORBILLIVIRUS; PARAMYXOVIRIDAE;

EID: 84860844283     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.342493     Document Type: Article

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