-
1
-
-
11444267243
-
Evaluation of the safety and immunogenicity of synthetic Aβ42 (AN1792) in patients with AD
-
Bayer AJ, Bullock R, Jones RW, Wilkinson D, Paterson KR, Jenkins L, Millais SB, Donoghue S (2005) Evaluation of the safety and immunogenicity of synthetic Abeta42 (AN1792) in patients with AD. Neurology 64:94-101 (Pubitemid 40082943)
-
(2005)
Neurology
, vol.64
, Issue.1
, pp. 94-101
-
-
Bayer, A.J.1
Bullock, R.2
Jones, R.W.3
Wilkinson, D.4
Paterson, K.R.5
Jenkins, L.6
Millais, S.B.7
Donoghue, S.8
-
2
-
-
0028875452
-
Recent developments in retro peptides and proteins - An ongoing topochemical exploration
-
Chorev M, Goodman M (1995) Recent developments in retro peptides and proteins - an ongoing topochemical exploration. Trends Biotechnol 13:438-445
-
(1995)
Trends Biotechnol
, vol.13
, pp. 438-445
-
-
Chorev, M.1
Goodman, M.2
-
3
-
-
0037155581
-
Brain to plasma amyloid-β efflux: A measure of brain amyloid burden in a mouse model of Alzheimer's disease
-
DOI 10.1126/science.1067568
-
Demattos RB, Bales KR, Cummins DJ, Paul SM, Holtzman DM (2002) Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease. Science 295:2264-2267 (Pubitemid 34258840)
-
(2002)
Science
, vol.295
, Issue.5563
, pp. 2264-2267
-
-
DeMattos, R.B.1
Bales, K.R.2
Cummins, D.J.3
Paul, S.M.4
Holtzman, D.M.5
-
4
-
-
0027167443
-
A comparison of the immunogenicity of a pair of enantiomeric proteins
-
Dintzis HM, Symer DE, Dintzis RZ, Zawadzke LE, Berg JM (1993) A comparison of the immunogenicity of a pair of enantiomeric proteins. Proteins 16:306-308 (Pubitemid 23183306)
-
(1993)
Proteins: Structure, Function and Genetics
, vol.16
, Issue.3
, pp. 306-308
-
-
Dintzis, H.M.1
Symer, D.E.2
Dintzis, R.Z.3
Zawadzke, L.E.4
Berg, J.M.5
-
5
-
-
0342378184
-
On the immunogenic properties of retro-inverso peptides. Total retro- inversion of T-cell epitopes causes a loss of binding to MHC II molecules
-
DOI 10.1016/S0161-5890(97)00004-7, PII S0161589097000047
-
Herve M, Maillere B, Mourier G, Texier C, Leroy S, Menez A (1997) On the immunogenic properties of retro-inverso peptides. Total retro-inversion of T-cell epitopes causes a loss of binding to MHC II molecules. Mol Immunol 34:157-163 (Pubitemid 27242697)
-
(1997)
Molecular Immunology
, vol.34
, Issue.2
, pp. 157-163
-
-
Herve, M.1
Maillere, B.2
Mourier, G.3
Texier, C.4
Leroy, S.5
Menez, A.6
-
6
-
-
0031914718
-
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
-
DOI 10.1038/nm0198-097
-
Holcomb L, Gordon MN, McGowan E, Yu X, Benkovic S, Jantzen P, Wright K, Saad I, Mueller R, Morgan D, Sanders S, Zehr C, O'campo K, Hardy J, Prada CM, Eckman C, Younkin S, Hsiao K, Duff K (1998) Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat Med 4:97-100 (Pubitemid 28133087)
-
(1998)
Nature Medicine
, vol.4
, Issue.1
, pp. 97-100
-
-
Holcomb, L.1
Gordon, M.N.2
Mcgowan, E.3
Yu, X.4
Benkovic, S.5
Jantzen, P.6
Wright, K.7
Saad, I.8
Mueller, R.9
Morgan, D.10
Sanders, S.11
Zehr, C.12
O'Campo, K.13
Hardy, J.14
Prada, C.-M.15
Eckman, C.16
Younkin, S.17
Hsiao, K.18
Duff, K.19
-
7
-
-
0029742199
-
Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice
-
DOI 10.1126/science.274.5284.99
-
Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G (1996) Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 274: 99-102 (Pubitemid 26332733)
-
(1996)
Science
, vol.274
, Issue.5284
, pp. 99-102
-
-
Hsiao, K.1
Chapman, P.2
Nilsen, S.3
Eckman, C.4
Harigaya, Y.5
Younkin, S.6
Yang, F.7
Cole, G.8
-
8
-
-
0035863055
-
Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease
-
Kawarabayashi T, Younkin LH, Saido TC, Shoji M, Ashe KH, Younkin SG (2001) Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J Neurosci 21:372-381 (Pubitemid 32107428)
-
(2001)
Journal of Neuroscience
, vol.21
, Issue.2
, pp. 372-381
-
-
Kawarabayashi, T.1
Younkin, L.H.2
Saido, T.C.3
Shoji, M.4
Ashe, K.H.5
Younkin, S.G.6
-
9
-
-
0037088956
-
Behavioral characterization of the Tg2576 transgenic model of Alzheimer's disease through 19 months
-
DOI 10.1016/S0031-9384(02)00639-X, PII S003193840200639X
-
King DL, Arendash GW (2002) Behavioral characterization of the Tg2576 transgenic model of Alzheimer's disease through 19 months. Physiol Behav 75:627-642 (Pubitemid 34521825)
-
(2002)
Physiology and Behavior
, vol.75
, Issue.5
, pp. 627-642
-
-
King, D.L.1
Arendash, G.W.2
-
10
-
-
33747484171
-
N-methylated peptide inhibitors of β-amyloid aggregation and toxicity. Optimization of the inhibitor structure
-
DOI 10.1021/bi060837s
-
Kokkoni N, Stott K, Amijee H, Mason JM, Doig AJ (2006) N-methylated peptide inhibitors of beta-amyloid aggregation and toxicity. Optimization of the inhibitor structure. Biochemistry 45:9906-9918 (Pubitemid 44257436)
-
(2006)
Biochemistry
, vol.45
, Issue.32
, pp. 9906-9918
-
-
Kokkoni, N.1
Stott, K.2
Amijee, H.3
Mason, J.M.4
Doig, A.J.5
-
11
-
-
0037223101
-
Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to β-amyloid
-
Matsuoka Y, Saito M, Lafrancois J, Gaynor K, Olm V, Wang L, Casey E, Lu Y, Shiratori C, Lemere C, Duff K (2003) Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to betaamyloid. J Neurosci 23:29-33 (Pubitemid 36050401)
-
(2003)
Journal of Neuroscience
, vol.23
, Issue.1
, pp. 29-33
-
-
Matsuoka, Y.1
Saito, M.2
LaFrancois, J.3
Saito, M.4
Gaynor, K.5
Olm, V.6
Wang, L.7
Casey, E.8
Lu, Y.9
Shiratori, C.10
Lemere, C.11
Duff, K.12
-
12
-
-
44649110724
-
Amyloid, Hyperactivity, and Metabolism: Theoretical Comment on Vloeberghs et al. (2008)
-
DOI 10.1037/0735-7044.122.3.730, PII S0735704408601068
-
Morgan D, Gordon MN (2008) Amyloid, hyperactivity, metabolism: theoretical comment on Vloeberghs et al. (2008). Behav Neurosci 122:730-732 (Pubitemid 351787852)
-
(2008)
Behavioral Neuroscience
, vol.122
, Issue.3
, pp. 730-732
-
-
Morgan, D.1
Gordon, M.N.2
-
13
-
-
10744230547
-
Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization
-
Orgogozo JM, Gilman S, Dartigues JF, Laurent B, Puel M, Kirby LC, Jouanny P, Dubois B, Eisner L, Flitman S, Michel BF, Boada M, Frank A, Hock C (2003) Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization. Neurology 61:46-54 (Pubitemid 36818745)
-
(2003)
Neurology
, vol.61
, Issue.1
, pp. 46-54
-
-
Orgogozo, J.-M.1
Gilman, S.2
Dartigues, J.-F.3
Laurent, B.4
Puel, M.5
Kirby, L.C.6
Jouanny, P.7
Dubois, B.8
Eisner, L.9
Flitman, S.10
Michel, B.F.11
Boada, M.12
Frank, A.13
Hock, C.14
-
14
-
-
34948888151
-
Clearance of amyloid-β by circulating lipoprotein receptors
-
DOI 10.1038/nm1635, PII NM1635
-
Sagare A, Deane R, Bell RD, Johnson B, Hamm K, Pendu R, Marky A, Lenting PJ, Wu Z, Zarcone T, Goate A, Mayo K, Perlmutter D, Coma M, Zhong Z, Zlokovic BV (2007) Clearance of amyloid-beta by circulating lipoprotein receptors. Nat Med 13:1029-1031 (Pubitemid 47517512)
-
(2007)
Nature Medicine
, vol.13
, Issue.9
, pp. 1029-1031
-
-
Sagare, A.1
Deane, R.2
Bell, R.D.3
Johnson, B.4
Hamm, K.5
Pendu, R.6
Marky, A.7
Lenting, P.J.8
Wu, Z.9
Zarcone, T.10
Goate, A.11
Mayo, K.12
Perlmutter, D.13
Coma, M.14
Zhong, Z.15
Zlokovic, B.V.16
-
15
-
-
0029784838
-
Amyloid β-protein and the genetics of Alzheimer's disease
-
Selkoe DJ (1996) Amyloid beta-protein and the genetics of Alzheimer's disease. J Biol Chem 271:18295-18298 (Pubitemid 26322675)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.31
, pp. 18295-18298
-
-
Selkoe, D.J.1
-
16
-
-
0034884382
-
Immunization with a nontoxic/nonfibrillar amyloid-β homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice
-
Sigurdsson EM, Scholtzova H, Mehta PD, Frangione B, Wisniewski T (2001) Immunization with a nontoxic/nonfibrillar amyloidbeta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice. Am J Pathol 159:439-447 (Pubitemid 32751074)
-
(2001)
American Journal of Pathology
, vol.159
, Issue.2
, pp. 439-447
-
-
Sigurdsson, E.M.1
Scholtzova, H.2
Mehta, P.D.3
Frangione, B.4
Wisniewski, T.5
-
17
-
-
0035433962
-
Alzheimer's disease and Aβ toxicity: From top to bottom
-
DOI 10.1038/35086072
-
Small DH, Mok SS, Bornstein JC (2001) Alzheimer's disease and Abeta toxicity: from top to bottom. Nat Rev Neurosci 2:595-598 (Pubitemid 33679833)
-
(2001)
Nature Reviews Neuroscience
, vol.2
, Issue.8
, pp. 595-598
-
-
Small, D.H.1
Mok, S.S.2
Bornstein, J.C.3
-
18
-
-
0031873102
-
β-Sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: Implications for Alzheimer's therapy
-
DOI 10.1038/nm0798-822
-
Soto C, Sigurdsson EM, Morelli L, Kumar RA, Castano EM, Frangione B (1998) Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy. Nat Med 4:822-826 (Pubitemid 28331024)
-
(1998)
Nature Medicine
, vol.4
, Issue.7
, pp. 822-826
-
-
Soto, C.1
Sigurdsson, E.M.2
Morelli, L.3
Kumar, R.A.4
Castano, E.M.5
Frangione, B.6
-
19
-
-
0033973997
-
In vitro evidence that β-amyloid peptide 1-40 diffuses across the blood-brain barrier and affects its permeability
-
Strazielle N, Ghersi-Egea JF, Ghiso J, Dehouck MP, Frangione B, Patlak C, Fenstermacher J, Gorevic P (2000) In vitro evidence that beta-amyloid peptide 1-40 diffuses across the blood-brain barrier and affects its permeability. J Neuropathol Exp Neurol 59:29-38 (Pubitemid 30069223)
-
(2000)
Journal of Neuropathology and Experimental Neurology
, vol.59
, Issue.1
, pp. 29-38
-
-
Strazielle, N.1
Ghersi-Egea, J.-F.2
Ghiso, J.3
Dehouck, M.-P.4
Frangione, B.5
Patlak, C.6
Fenstermacher, J.7
Gorevic, P.8
-
21
-
-
0030953792
-
Controlling amyloid β-peptide fibril formation with protease-stable ligand
-
DOI 10.1074/jbc.272.19.12601
-
Tjernberg LO, Lilliehook C, Callaway DJ, Naslund J, Hahne S, Thyberg J, Terenius L, Nordstedt C (1997) Controlling amyloid beta-peptide fibril formation with protease-stable ligands. J Biol Chem 272:12601-12605 (Pubitemid 27203354)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.19
, pp. 12601-12605
-
-
Tjernberg, L.O.1
Lilliehook, C.2
Callaway, D.J.E.3
Naslund, J.4
Hahne, S.5
Thyberg, J.6
Terenius, L.7
Nordstedt, C.8
-
22
-
-
0029994633
-
Arrest of β-amyloid fibril formation by a pentapeptide ligand
-
DOI 10.1074/jbc.271.15.8545
-
Tjernberg LO, Näslund J, Lindqvist F, Johansson J, Karlström AR, Thyberg J, Terenius L, Nordstedt C (1996) Arrest of betaamyloid fibril formation by a pentapeptide ligand. J Biol Chem 271(15):8545-8548 (Pubitemid 26123269)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.15
, pp. 8545-8548
-
-
Tjernberg, L.O.1
Naslundt, J.2
Lindqvist, F.3
Johansson, J.4
Karlstrom, A.R.5
Thyberg, J.6
Tereniust, L.7
Nordstedt, C.8
-
23
-
-
12244305529
-
Multiple-peptide conjugates for binding β-amyloid plaques of Alzheimer's disease
-
DOI 10.1021/bc025526i
-
Zhang G, Leibowitz MJ, Sinko PJ, Stein S (2003) Multiple-peptide conjugates for binding beta-amyloid plaques of Alzheimer's disease. Bioconjugate Chem 14:86-92 (Pubitemid 36169021)
-
(2003)
Bioconjugate Chemistry
, vol.14
, Issue.1
, pp. 86-92
-
-
Zhang, G.1
Leibowitz, M.J.2
Sinko, P.J.3
Stein, S.4
|