Ultra-structural defects cause low bone matrix stiffness despite high mineralization in osteogenesis imperfecta mice

Bone

Volumn 50, Issue 6, 2012, Pages 1317-1323

  Vanleene, Maximilien ^a   Porter, Alexandra ^a   Guillot, Pascale Valerie ^a   Boyde, Alan ^b   Oyen, Michelle ^c   Shefelbine, Sandra ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Bone matrix; Mineralization; Mouse model; Osteogenesis imperfecta; Stiffness

Indexed keywords

APATITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE DENSITY; BONE MATRIX; BONE MINERALIZATION; CONTROLLED STUDY; ELASTICITY; ELECTRON MICROSCOPY; MOUSE; MUSCULOSKELETAL STIFFNESS; NONHUMAN; OSTEOGENESIS IMPERFECTA; QUANTITATIVE BACKSCATTERED ELECTRON MICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE; YOUNG MODULUS;

ANIMALS; APATITES; BIOMECHANICS; BONE DENSITY; BONE MATRIX; CRYSTALLIZATION; DISEASE MODELS, ANIMAL; ELASTIC MODULUS; FEMALE; MALE; MICE; MICE, MUTANT STRAINS; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, ELECTRON, TRANSMISSION; OSTEOGENESIS IMPERFECTA; STRESS, MECHANICAL;

EID: 84860840663     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2012.03.007     Document Type: Article

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