Tachykinin NK 1 receptor antagonist co-administration attenuates opioid withdrawal-mediated spinal microglia and astrocyte activation

European Journal of Pharmacology

Volumn 684, Issue 1-3, 2012, Pages 64-70

  Tumati, Suneeta ^a   Largent Milnes, Tally M ^a   Keresztes, Attila I ^a   Yamamoto, Takashi ^b   Vanderah, Todd W ^a,c   Roeske, William R ^a,d   Hruby, Victor J ^b   Varga, Eva V ^a,d  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b University of Arizona   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

^d UNIVERSITY OF ARIZONA   (United States)

Author keywords

Opioid induced hyperalgesia; Spinal glia; Tachykinin NK1 receptor antagonist; Tachykinin NK 1 receptor

Indexed keywords

MORPHINE; N ACETYL LEVO TRYPTOPHAN 3,5 BIS(TRIFLUOROMETHYL)BENZYLESTER; N ACETYLTRYPTOPHAN 3,5 BIS(TRIFLUOROMETHYL)BENZYL ESTER; NEUROKININ 1 RECEPTOR ANTAGONIST; OPIATE; OPIATE AGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL ACTIVATION; CONTROLLED STUDY; COVALENT BOND; GLIA CELL; HYPERALGESIA; IMMUNOREACTIVITY; MALE; MICROGLIA; NOCICEPTION; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; RAT;

ANALGESICS, OPIOID; ANIMALS; ANTIGENS, CD11B; ASTROCYTES; BIOLOGICAL MARKERS; HYPERALGESIA; MALE; MICROGLIA; MORPHINE; NERVE TISSUE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NEUROKININ-1; SPINAL CORD; SUBSTANCE WITHDRAWAL SYNDROME; TRYPTOPHAN; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84860834059     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.03.025     Document Type: Article

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