HHV-8 reduces dendritic cell migration through down-regulation of cell-surface CCR6 and CCR7 and cytoskeleton reorganization

Virology Journal

Volumn 9, Issue , 2012, Pages

  Cirone, Mara ^a   Conte, Valeria ^a   Farina, Antonella ^a   Valia, Sandro ^a   Trivedi, Pankaj ^a   Granato, Marisa ^a   Santarelli, Roberta ^a   Frati, Luigi ^a   Faggioni, Alberto ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Chemokine receptors; Chemokines; Dendritic cells.; HHV 8

Indexed keywords

CELL SURFACE RECEPTOR; CHEMOKINE RECEPTOR CCR6; CHEMOKINE RECEPTOR CCR7; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; STAT3 PROTEIN; TUBULIN;

ARTICLE; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; CYTOSKELETON; DENDRITIC CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; INFLAMMATION; LYMPHOID ORGAN; NONHUMAN; RECEPTOR DOWN REGULATION; VIRUS INFECTION;

CELL MOVEMENT; CYTOSKELETON; DENDRITIC CELLS; DOWN-REGULATION; HERPESVIRUS 8, HUMAN; HUMANS; IMMUNE EVASION; RECEPTORS, CCR6; RECEPTORS, CCR7;

HUMAN HERPESVIRUS 8;

EID: 84860830226     PISSN: None     EISSN: 1743422X     Source Type: Journal    
DOI: 10.1186/1743-422X-9-92     Document Type: Article

References (21)

1. Immunobiology of dendritic cells. Banchereau J, Breire F, Caux C, Davoust J, Lebecque S, Liu YJ, Puledran B, Palucka K, Annu Rev Immunol 2000 18 767 811 10.1146/annurev.immunol.18.1.767 10837075 (Pubitemid 30365397)
2. Chemokines and dendritic cell traffic. Sozzani S, Allavena P, Vecchi A, Mantovani A, J Clin Immunol 2000 20 151 160 10.1023/A:1006659211340 10941822 (Pubitemid 30485875)
3. Receptor expression and responsiveness of human dendritic cells to a defined set of CC and CXC chemokines. Sozzani S, Luini W, Borsatti A, Polentarutti N, Zhou D, Piemonti L, D'Amico G, Power CA, Wells TN, Gobbi M, Allavena P, Mantovani A, J Immunol 1997 159 1993 2000 9257866 (Pubitemid 127484190)
4. Dendritic cell biology and regulation of dendritic cell trafficking by chemokines. Caux C, Ait-Yahia S, Chemin K, de Bouteiller O, Dieu-Nosjean MC, Homey B, Massacrier C, Vanbervliet B, Zlotnik A, Vicari A, Springer Semin Immunopathol 2000 22 345 369 10.1007/s002810000053 11155441
5. CCL20/CCR6 blockade enhances immunity to RSV by impairing recruitment of DC. Kallal LE, Schaller MA, Lindell DM, Lira SA, Lukacs NW, Eur J Immunol. 2010 40 1042 1052 10.1002/eji.200939778 20101616
6. CCR7 and its ligands: balancing immunity and tolerance. Förster R, Davalos-Misslitz AC, Rot A, Nat Rev Immunol 2008 8 362 371 10.1038/nri2297 18379575 (Pubitemid 351595218)
7. Vaccinia virus impairs directional migration and chemokine receptor switch of human dendritic cells. Humrich JY, Thumann P, Greiner S, Humrich JH, Averbeck M, Schwank C, Kämpgen E, Schuler G, Jenne L, Eur J Immunol 2007 37 954 965 10.1002/eji.200636230 17357104 (Pubitemid 46925333)
8. Controls for lung dendritic cell maturation and migration during respiratory viral infection. Grayson MH, Ramos MS, Rohlfing MM, Kitchens R, Wang HD, Gould A, Agapov E, Holtzman MJ, J Immunol 2007 179 1438 1348 17641009
9. Infection of mature dendritic cells with herpes simplex virus type 1 dramatically reduces lymphoid chemokine-mediated migration. Prechtel AT, Turza NM, Kobelt DJ, Eisemann JI, Coffin RS, McGrath Y, Hacker C, Ju X, Zenke M, Steinkasserer A, J Gen Virol 2005 86 1645 1657 10.1099/vir.0.80852-0 15914842 (Pubitemid 40774765)
10. Human cytomegalovirus inhibits the migration of immature dendritic cells by down-regulating cell-surface CCR1 and CCR5. Varani S, Frascaroli G, Homman-Loudiyi M, Feld S, Landini MP, Söderberg-Nauclér C, J Leukoc Biol 2005 77 219 228 15522919 (Pubitemid 40315056)
11. Impaired lymphoid chemokine-mediated migration due to a block on the chemokine receptor switch in human cytomegalovirus-infected dendritic cells. Moutaftsi M, Brennan P, Spector SA, Tabi Z, J Virol 2004 78 3046 3054 10.1128/JVI.78.6.3046-3054.2004 14990723 (Pubitemid 38314362)
12. AIDS-related malignancies. Boshoff C, Weiss R, Nat Rev Cancer 2002 2 373 382 10.1038/nrc797 12044013 (Pubitemid 37328950)
13. DC-SIGN is a receptor for human herpesvirus 8 on dendritic cells and macrophages. Rappocciolo G, Jenkins FJ, Hensler HR, Piazza P, Jais M, Borowski L, Watkins SC, Rinaldo CR, J Immunol 2006 17 1741 1749 (Pubitemid 43134319)
14. Human herpesvirus 8 (HHV-8) inhibits monocyte differentiation into dendritic cells and impairs their immunostimulatory activity. Cirone M, Lucania G, Bergamo P, Trivedi P, Frati L, Faggioni A, Immunol Lett 2007 113 40 46 10.1016/j.imlet.2007.07.013 17822781 (Pubitemid 47464619)
15. Quantitative analysis of human herpesvirus 8 viral load using a real-time PCR assay. Lallemand F, Desire N, Rozenbaum W, Nicolas JC, Marechal V, J Clin Microbiol 2000 38 1404 1408 10747115 (Pubitemid 30216662)
16. The CC chemokine CCL20 and its receptor CCR6. Schutyser E, Struyf S, Van Damme J, Cytokine Growth Factor Rev 2003 14 409 426 10.1016/S1359-6101(03)00049- 2 12948524 (Pubitemid 37099454)
17. The chemokine receptor switch paradigm and dendritic cell migration: its significance in tumor tissues. Allavena P, Sica A, Vecchi A, Locati M, Sozzani S, Mantovani A, Immunol Rev 2000 177 141 149 10.1034/j.1600-065X.2000.17714.x 11138772
18. Manipulation of dendritic cell function by viruses. Cunningham AL, Donaghy H, Harman AN, Kim M, Turville SG, Curr Opin Microbiol 2010 13 524 529 10.1016/j.mib.2010.06.002 20598938
19. Cytokine production by human herpesvirus 8-infected cells. Hensler HR, Rappocciolo G, Rinaldo CR, Jenkins FJ, J Gen Virol 2009 90 79 83 10.1099/vir.0.006239-0 19088276
20. Infection of dendritic cells with herpes simplex type 1 induces rapid degradation of CYTIP, thereby modulating adhesion and migration. Theodoridis AA, Eich C, Figdor CG, Steinkasserer A, Blood 2011 118 105 115
21. Hyperactivation of STAT3 is involved in abnormal differentiation of dendritic cells in cancer. Nefedova Y, Huang M, Kusmartsev S, Battacharya R, Cheng P, Salup R, Jove R, Gabrilovich D, J. Immunol. 2004 172 464 474 14688356 (Pubitemid 38020502)