Familial effects on ischemic stroke the role of sibling kinship, sex, and age of onset

Circulation: Cardiovascular Genetics

Volumn 5, Issue 2, 2012, Pages 226-233

  Kasiman, Katherine ^a,b   Lundholm, Cecilia ^a   Sandin, Sven ^a   Malki, Ninoa ^a   Sparén, Pär ^a   Ingelsson, Erik ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Epidemiology; Family history; Heritability; Ischemic stroke; Sex

Indexed keywords

ADULT; AGED; ARTICLE; BRAIN ISCHEMIA; DISEASE REGISTRY; FAMILY HISTORY; FEMALE; HERITABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PRIORITY JOURNAL; RISK FACTOR; SEX DIFFERENCE; SIBLING;

AGE OF ONSET; AGED; COHORT STUDIES; CONFIDENCE INTERVALS; FEMALE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; PEDIGREE; RISK FACTORS; SEX FACTORS; SIBLINGS; STROKE; SWEDEN;

EID: 84860820236     PISSN: 1942325X     EISSN: 19423268     Source Type: Journal    
DOI: 10.1161/CIRCGENETICS.111.962241     Document Type: Article

References (22)

1. Bak S, Gaist D, Sindrup SH, Skytthe A, Christensen K. Genetic liability in stroke: A long-term follow-up study of Danish twins. Stroke. 2002;33: 769-774. (Pubitemid 34204005)
2. Brass LM, Isaacsohn JL, Merikangas KR, Robinette CD. A study of twins and stroke. Stroke. 1992;23:221-223.
3. Kiely DK, Wolf PA, Cupples LA, Beiser AS, Myers RH. Familial aggregation of stroke. The Framingham study. Stroke. 1993;24: 1366-1371. (Pubitemid 23254641)
4. MacClellan LR, Mitchell BD, Cole JW, Wozniak MA, Stern BJ, Giles WH, Brown DW, Sparks MJ, Kittner SJ. Familial aggregation of ischemic stroke in young women: The Stroke Prevention in Young Women Study. Genet Epidemiol. 2006;30:602-608. (Pubitemid 44630930)
5. Meschia JF, Atkinson EJ, O'Brien PC, Brott TG, Brown RD Jr, Hardy J. Familial clustering of stroke according to proband age at onset of presenting ischemic stroke. Stroke. 2003;34:e89-e91.
6. Meschia JF, Nalls M, Matarin M, Brott TG, Brown RD Jr, Hardy J, Kissela B, Rich SS, Singleton A, Hernandez D, Ferrucci L, Pearce K, Keller M, Worrall BB; Siblings With Ischemic Stroke Study Investigators. Siblings with ischemic stroke study: Results of a genome-wide scan for stroke loci. Stroke. 2011;42:2726-2732.
7. Meschia JF, Singleton A, Nalls MA, Rich SS, Sharma P, Ferrucci L, Matarin M, Hernandez DG, Pearce K, Brott TG, Brown RD Jr, Hardy J, Worrall BB. Genomic risk profiling of ischemic stroke: Results of an international genome-wide association meta-analysis. PLoS One. 2011;6:e23161.
8. Flossmann E, Schulz UG, Rothwell PM. Systematic review of methods and results of studies of the genetic epidemiology of ischemic stroke. Stroke. 2004;35:212-227. (Pubitemid 38057622)
9. Sundquist K, Li X, Hemminki K. Familial risk of ischemic and hemorrhagic stroke: A large-scale study of the Swedish population. Stroke. 2006;37:1668-1673. (Pubitemid 44297710)
10. Diaz JF, Hachinski VC, Pederson LL, Donald A. Aggregation of multiple risk factors for stroke in siblings of patients with brain infarction and transient ischemic attacks. Stroke. 1986;17:1239-1242. (Pubitemid 17008963)
11. Flossmann E, Rothwell PM. Family history of stroke does not predict risk of stroke after transient ischemic attack. Stroke. 2006;37:544-546. (Pubitemid 43732023)
12. Jerrard-Dunne P, Cloud G, Hassan A, Markus HS. Evaluating the genetic component of ischemic stroke subtypes: A family history study. Stroke. 2003;34:1364-1369. (Pubitemid 36693499)
13. Jood K, Ladenvall C, Rosengren A, Blomstrand C, Jern C. Family history in ischemic stroke before 70 years of age: The Sahlgrenska Academy Study on Ischemic Stroke. Stroke. 2005;36:1383-1387. (Pubitemid 40967498)
14. Schulz UG, Flossmann E, Rothwell PM. Heritability of ischemic stroke in relation to age, vascular risk factors, and subtypes of incident stroke in population-based studies. Stroke. 2004;35:819-824. (Pubitemid 38419784)
15. Touzé E, Rothwell PM. Heritability of ischaemic stroke in women compared with men: A genetic epidemiological study. Lancet Neurol. 2007;6:125-133. (Pubitemid 46097526)
16. Touzé E, Rothwell PM. Sex differences in heritability of ischemic stroke: A systematic review and meta-analysis. Stroke. 2008;39:16-23.
17. Wiklund PG, Brown WM, Brott TG, Stegmayr B, Brown RD Jr, Nilsson-Ardnor S, Hardy JA, Kissela BM, Singleton A, Holmberg D, Rich SS, Meschia JF. Lack of aggregation of ischemic stroke subtypes within affected sibling pairs. Neurology. 2007;68:427-431. (Pubitemid 46208745)
18. Appelros P, Terent A. Validation of the Swedish inpatient and causeof-death registers in the context of stroke. Acta Neurol Scand. 2011;123: 289-293.
19. Grambsch PM, Therneau TM. Proportional hazards tests and diagnostics based on weighted residuals. Biometrika. 1994;81:515-526.
20. Feigin VL, Lawes CM, Bennett DA, Anderson CS. Stroke epidemiology: A review of population-based studies of incidence, prevalence, and casefatality in the late 20th century. Lancet Neurol. 2003;2:43-53. (Pubitemid 37443343)
21. Rothwell PM, Coull AJ, Silver LE, Fairhead JF, Giles MF, Lovelock CE, Redgrave JN, Bull LM, Welch SJ, Cuthbertson FC, Binney LE, Gutnikov SA, Anslow P, Banning AP, Mant D, Mehta Z; Oxford Vascular Study. Population-based study of event-rate, incidence, case fatality, and mortality for all acute vascular events in all arterial territories (Oxford Vascular Study). Lancet. 2005;366:1773-1783. (Pubitemid 41642641)
22. Choi JC, Lee JS, Kang SY, Kang JH, Bae JM. Family history and risk for ischemic stroke: Sibling history is more strongly correlated with the disease than parental history. J Neurol Sci. 2009;284:29-32.