-
1
-
-
79960202841
-
Type 2 diabetes across generations: From pathophysiology to prevention and management
-
Nolan CJ, Damm P, Prentki M (2011) Type 2 diabetes across generations: From pathophysiology to prevention and management. Lancet 378:169-181.
-
(2011)
Lancet
, vol.378
, pp. 169-181
-
-
Nolan, C.J.1
Damm, P.2
Prentki, M.3
-
2
-
-
79960995107
-
Macrovascular effects and safety issues of therapies for type 2 diabetes
-
Plutzky J (2011) Macrovascular effects and safety issues of therapies for type 2 diabetes. Am J Cardiol 108(3, suppl)25B-32B.
-
(2011)
Am J Cardiol
, vol.108
, Issue.3 SUPPL.
-
-
Plutzky, J.1
-
3
-
-
70349329717
-
Antidiabetic agents and cardiovascular risk in type 2 diabetes
-
Zarich SW (2009) Antidiabetic agents and cardiovascular risk in type 2 diabetes. Nat Rev Endocrinol 5: 500-506.
-
(2009)
Nat Rev Endocrinol
, vol.5
, pp. 500-506
-
-
Zarich, S.W.1
-
4
-
-
79959807374
-
Type 2 diabetes can be prevented with early pharmacological intervention
-
DeFronzo RA, Abdul-Ghani M (2011) Type 2 diabetes can be prevented with early pharmacological intervention. Diabetes Care 34(suppl 2):S202-S209.
-
(2011)
Diabetes Care
, vol.34
, Issue.SUPPL. 2
-
-
DeFronzo, R.A.1
Abdul-Ghani, M.2
-
5
-
-
84860795758
-
Amorfrutins are potent anti-diabetic dietary natural products
-
Weidner C, et al. (2012) Amorfrutins are potent anti-diabetic dietary natural products. Proc Natl Acad Sci USA 109:7257-7262.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 7257-7262
-
-
Weidner, C.1
-
6
-
-
0029016829
-
An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator- Activated receptor gamma (PPAR gamma)
-
Lehmann JM, et al. (1995) An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator- activated receptor gamma (PPAR gamma). J Biol Chem 270:12953-12956.
-
(1995)
J Biol Chem
, vol.270
, pp. 12953-12956
-
-
Lehmann, J.M.1
-
7
-
-
77955657267
-
Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: The missing links. The Claude Bernard Lecture 2009
-
DeFronzo RA (2010) Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: The missing links. The Claude Bernard Lecture 2009. Diabetologia 53: 1270-1287.
-
(2010)
Diabetologia
, vol.53
, pp. 1270-1287
-
-
DeFronzo, R.A.1
-
8
-
-
76049086229
-
PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization
-
Sugii S, et al. (2009) PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization. Proc Natl Acad Sci USA 106:22504-22509.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 22504-22509
-
-
Sugii, S.1
-
9
-
-
34547431645
-
Adipose tissue expandability in the maintenance of metabolic homeostasis
-
Gray SL, Vidal-Puig AJ (2007) Adipose tissue expandability in the maintenance of metabolic homeostasis. Nutr Rev 65:S7-S12.
-
(2007)
Nutr Rev
, vol.65
-
-
Gray, S.L.1
Vidal-Puig, A.J.2
-
10
-
-
34249907880
-
Macrophage PPARgamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones
-
DOI 10.1172/JCI31561
-
Hevener AL, et al. (2007) Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J Clin Invest 117:1658-1669. (Pubitemid 46871350)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.6
, pp. 1658-1669
-
-
Hevener, A.L.1
Olefsky, J.M.2
Reichart, D.3
Nguyen, M.T.A.4
Bandyopadyhay, G.5
Leung, H.-Y.6
Watt, M.J.7
Benner, C.8
Febbraio, M.A.9
Nguyen, A.-K.10
Folian, B.11
Subramaniam, S.12
Gonzalez, F.J.13
Glass, C.K.14
Ricote, M.15
-
11
-
-
79955694276
-
Brain PPAR-γ promotes obesity and is required for the insulin-sensitizing effect of thiazolidinediones
-
Lu M, et al. (2011) Brain PPAR-γ promotes obesity and is required for the insulin-sensitizing effect of thiazolidinediones. Nat Med 17:618-622.
-
(2011)
Nat Med
, vol.17
, pp. 618-622
-
-
Lu, M.1
-
12
-
-
77955285732
-
Rosiglitazone revisited: An updated meta-analysis of risk for myocardial infarction and cardiovascular mortality
-
Nissen SE, Wolski K (2010) Rosiglitazone revisited: An updated meta-analysis of risk for myocardial infarction and cardiovascular mortality. Arch Intern Med 170: 1191-1201.
-
(2010)
Arch Intern Med
, vol.170
, pp. 1191-1201
-
-
Nissen, S.E.1
Wolski, K.2
-
13
-
-
63849148589
-
Safety and tolerability of pioglitazone in high-risk patients with type 2 diabetes: An overview of data from PROactive
-
PROactive Investigators
-
Dormandy J, Bhattacharya M, van Troostenburg de Bruyn AR; PROactive Investigators (2009) Safety and tolerability of pioglitazone in high-risk patients with type 2 diabetes: An overview of data from PROactive. Drug Saf 32:187-202.
-
(2009)
Drug Saf
, vol.32
, pp. 187-202
-
-
Dormandy, J.1
Bhattacharya, M.2
Van Troostenburg De Bruyn, A.R.3
-
14
-
-
79951716557
-
Type 2 diabetes: Uses of thiazolidinediones and insulin
-
Bloomgarden ZT (2011) Type 2 diabetes: Uses of thiazolidinediones and insulin. Diabetes Care 34:e11-e16.
-
(2011)
Diabetes Care
, vol.34
-
-
Bloomgarden, Z.T.1
-
15
-
-
77952492038
-
Discovery and development of selective PPAR gamma modulators as safe and effective antidiabetic agents
-
Doshi LS, Brahma MK, Bahirat UA, Dixit AV, Nemmani KV (2010) Discovery and development of selective PPAR gamma modulators as safe and effective antidiabetic agents. Expert Opin Investig Drugs 19: 489-512.
-
(2010)
Expert Opin Investig Drugs
, vol.19
, pp. 489-512
-
-
Doshi, L.S.1
Brahma, M.K.2
Bahirat, U.A.3
Dixit, A.V.4
Nemmani, K.V.5
-
16
-
-
2642557181
-
A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity
-
DOI 10.1016/S1097-2765(01)00353-7
-
Rocchi S, et al. (2001) A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity. Mol Cell 8:737-747. (Pubitemid 33030208)
-
(2001)
Molecular Cell
, vol.8
, Issue.4
, pp. 737-747
-
-
Rocchi, S.1
Picard, F.2
Vamecq, J.3
Gelman, L.4
Potier, N.5
Zeyer, D.6
Dubuquoy, L.7
Bac, P.8
Champy, M.-F.9
Plunket, K.D.10
Leesnitzer, L.M.11
Blanchard, S.G.12
Desreumaux, P.13
Moras, D.14
Renaud, J.-P.15
Auwerx, J.16
-
17
-
-
35748941359
-
S 26948: A new specific peroxisome proliferator-activated receptor gamma modulator with potent antidiabetes and antiatherogenic effects
-
DOI 10.2337/db06-1734
-
Carmona MC, et al. (2007) S 26948, a new specific PPARγ modulator (SPPARM) with potent antidiabetic and antiatherogenic effects. Diabetes 56:2797-2808. (Pubitemid 350044924)
-
(2007)
Diabetes
, vol.56
, Issue.11
, pp. 2797-2808
-
-
Carmona, M.C.1
Louche, K.2
Lefebvre, B.3
Pilon, A.4
Hennuyer, N.5
Audinot-Bouchez, V.6
Fievet, C.7
Torpier, G.8
Formstecher, P.9
Renard, P.10
Lefebvre, P.11
Dacquet, C.12
Staels, B.13
Casteilla, L.14
Penicaud, L.15
-
18
-
-
33750580948
-
Halofenate is a selective peroxisome proliferator-activated receptor{gamma} modulator with antidiabetic activity
-
DOI 10.2337/db06-0618
-
Allen T, et al. (2006) Halofenate is a selective peroxisome proliferator-activated receptor gamma modulator with antidiabetic activity. Diabetes 55:2523-2533. (Pubitemid 44871152)
-
(2006)
Diabetes
, vol.55
, Issue.9
, pp. 2523-2533
-
-
Allen, T.1
Zhang, F.2
Moodie, S.A.3
Clemens, L.E.4
Smith, A.5
Gregoire, F.6
Bell, A.7
Muscat, G.E.O.8
Gustafson, T.A.9
-
19
-
-
77951865861
-
Proteasomal degradation of retinoid X receptor alpha reprograms transcriptional activity of PPARgamma in obese mice and humans
-
Lefebvre B, et al. (2010) Proteasomal degradation of retinoid X receptor alpha reprograms transcriptional activity of PPARgamma in obese mice and humans. J Clin Invest 120:1454-1468.
-
(2010)
J Clin Invest
, vol.120
, pp. 1454-1468
-
-
Lefebvre, B.1
-
20
-
-
80053131732
-
Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation
-
Choi JH, et al. (2011) Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation. Nature 477:477-481.
-
(2011)
Nature
, vol.477
, pp. 477-481
-
-
Choi, J.H.1
-
21
-
-
84863012459
-
Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones
-
Dutchak PA, et al. (2012) Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones. Cell 148:556-567.
-
(2012)
Cell
, vol.148
, pp. 556-567
-
-
Dutchak, P.A.1
-
22
-
-
84859157277
-
Roles of PPARs in NAFLD: Potential therapeutic targets
-
Tailleux A, Wouters K, Staels B (2011) Roles of PPARs in NAFLD: Potential therapeutic targets. Biochim Biophys Acta 1821:809-818.
-
(2011)
Biochim Biophys Acta
, vol.1821
, pp. 809-818
-
-
Tailleux, A.1
Wouters, K.2
Staels, B.3
-
23
-
-
81055144760
-
Adipocyte NCoR knockout decreases PPARγ phosphorylation and enhances PPARγ activity and insulin sensitivity
-
Li P, et al. (2011) Adipocyte NCoR knockout decreases PPARγ phosphorylation and enhances PPARγ activity and insulin sensitivity. Cell 147:815-826.
-
(2011)
Cell
, vol.147
, pp. 815-826
-
-
Li, P.1
-
24
-
-
25144441178
-
Fluid retention mediated by renal PPAR-gamma
-
Staels B (2005) Fluid retention mediated by renal PPAR-gamma. Cell Metab 2:77-78.
-
(2005)
Cell Metab
, vol.2
, pp. 77-78
-
-
Staels, B.1
-
25
-
-
56049115334
-
Phenolic constituents of Amorpha fruticosa that inhibit NF-kappaB activation and related gene expression
-
Dat NT, et al. (2008) Phenolic constituents of Amorpha fruticosa that inhibit NF-kappaB activation and related gene expression. J Nat Prod 71:1696-1700.
-
(2008)
J Nat Prod
, vol.71
, pp. 1696-1700
-
-
Dat, N.T.1
-
27
-
-
0942276510
-
Identification of a novel mitochondrial protein ("mitoNEET") cross-linked specifically by a thiazolidinedione photoprobe
-
Colca JR, et al. (2004) Identification of a novel mitochondrial protein ("mitoNEET") cross-linked specifically by a thiazolidinedione photoprobe. Am J Physiol Endocrinol Metab 286:E252-E260. (Pubitemid 38140317)
-
(2004)
American Journal of Physiology - Endocrinology and Metabolism
, vol.286
, Issue.2
-
-
Colca, J.R.1
McDonald, W.G.2
Waldon, D.J.3
Leone, J.W.4
Lull, J.M.5
Bannow, C.A.6
Lund, E.T.7
Mathews, W.R.8
|