Future perspectives on brain metastasis management

Progress in Neurological Surgery

Volumn 25, Issue , 2012, Pages 287-308

  Monaco Iii, Edward A ^a   Parry, Phillip V ^a   Grandhi, Ramesh ^a   Niranjan, Ajay ^a   Kano, Hideyuki ^a   Lunsford, L Dade ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BRAIN TUMOR; COMPARATIVE STUDY; FORECASTING; HUMAN; INSTRUMENTATION; METASTASIS; METHODOLOGY; MULTIMODALITY CANCER THERAPY; RADIOSURGERY; SKULL IRRADIATION;

BRAIN NEOPLASMS; COMBINED MODALITY THERAPY; CRANIAL IRRADIATION; FORECASTING; HUMANS; RADIOSURGERY;

EID: 84860793706     PISSN: 00796492     EISSN: 16623924     Source Type: Book Series    
DOI: 10.1159/000331201     Document Type: Article

References (107)

1. Loeffler JS, Patchell RA, Sawaya R: Metastatic brain cancer; in DeVita VT, Hellman S, Rosenberg SA (eds): Cancer: Principles and Practice of Oncology. Philadelphia, Lippincott-Raven, 1997.
2. Minna JD, Pass H: Cancer of lung; in DeVita VT, Hellman S, Rosenberg SA (eds): Cancer: Principles and Practice of Oncology. Philadelphia, Lippincott, 1989, pp 591-705.
3. Sawaya R, Bindal RK: Metastatic brain tumors; in Kaye AH, Laws ER (eds): Brain Tumors: An Encyclopedic Approach. Edinburgh, Churchill Livingstone, 1995, pp 923-946.
4. Wen PY, Loeffler JS: Management of brain metastases. Oncology (Williston Park) 1999;13:941-954, 957-961.
5. Posner JB: Diagnosis and treatment of metastases to the brain. Clin Bull 1974;4:47-57.
6. Harzra T, Mullins GN, Lott S: Management of cerebral metastases from bronchogenic carcinoma. Johns Hopkins Med J 1972;130:377-383.
7. Cairncross JG, Kim JH, Posner JB: Radiation therapy for brain metastases. Ann Neurol 1980;7:529-541.
8. Hendrickson FR: The optimun schedule for palliative radiotherapy for metastatic brain cancer. Int J Radiat Oncol Biol Phys 1977;2:165-168.
9. Komarnicky LT, Phillips TL, Martz K, Asbell S, Isaacson S, Urtasun R: A randomized phase iii protocol for the evaluation of misonidazole combined with radiation in the treatment of patients with brain metastases (RTOG-7916). Int J Radiat Oncol Biol Phys 1991;20:53-58.
10. Phillips TL, Scott CB, Leibel SA, Rotman M, Weigensberg IJ: Results of a randomized comparison of radiotherapy and bromodeoxyuridine with radiotherapy alone for brain metastases: report of RTOG trial 89-05. Int J Radiat Oncol Biol Phys 1995;33:339-348.
11. Sause WT, Crowley JJ, Morantz R, Rotman M, Mowry PA, Bouzaglou A, Borst JR, Selin H: Solitary brain metastasis: results of an RTOG/SWOG protocol evaluation surgery + RT versus RT alone. Am J Clin Oncol 1990;13:427-432.
12. Tsao MN, Lloyd N, Wong R, Chow E, Rakovitch E, Laperriere N: Whole brain radiotherapy for the treatment of multiple brain metastases. Cochrane Database Syst Rev 2006;3:CD003869.
13. Khuntia D, Brown P, Li J, Mehta MP: Whole-brain radiotherapy in the management of brain metastasis. J Clin Oncol 2006;24:1295-1304.
14. Gaspar L, Scott C, Rotman M, Asbell S, Phillips T, Wasserman T, McKenna WG, Byhardt R: Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials. Int J Radiat Oncol Biol Phys 1997;37:745-751.
15. Magilligan DJ Jr, Duvernoy C, Malik G, Lewis JW Jr, Knighton R, Ausman JI: Surgical approach to lung cancer with solitary cerebral metastasis: twenty-five years' experience. Ann Thorac Surg 1986;42:360-364.
16. Sawaya R: Considerations in the diagnosis and management of brain metastases. Oncology (Williston Park) 2001;15:1144-1154, 1157-1148.
17. Lohr F, Pirzkall A, Hof H, Fleckenstein K, Debus J: Adjuvant treatment of brain metastases. Semin Surg Oncol 2001;20:50-56.
18. Lunsford LD, Niranjan A, Kondziolka D: Oncopolitics: Where does the neurosurgeon fit in the management of brain cancer? Clin Neurosurg 2008;55:35-46.
19. Patchell RA, Tibbs PA, Walsh J W, Dempsey RJ, Maruyama Y, Kryscio RJ, Markesbery WR, Macdonald JS, Young B: A randomized trial of surgery in the treatment of single metastases to the brain. N Engl J Med 1990;322:494-500.
20. Vecht CJ, Haaxma-Reiche H, Noordijk EM, et al: Treatment of single brain metastasis: radiotherapy alone or combined with neurosurgery? Ann Neurol 1993;33:583-590.
21. Mintz AH, Kestle J, Rathbone M P, Gaspar L, Hugenholtz H, Fisher B, Duncan G, Skingley P, Foster G, Levine M: A randomized trial to assess the efficacy of surgery in addition to radiotherapy in patients with a single cerebral metastasis. Cancer 1996;78:1470-1476.
22. Patchell RA, Tibbs PA, Regine WF, Dempsey RJ, Mohiuddin M, Kryscio RJ, Markesbery WR, Foon KA, Young B: Postoperative radiotherapy in the treatment of single metastases to the brain: a randomized trial. JAMA 1998;280:1485-1489.
23. Kim CH, Im YS, Nam DH, Park K, Kim JH, Lee JI: Gamma Knife radiosurgery for ten or more brain metastases. J Korean Neurosurg Soc 2008;44:358-363.
24. Outcomes of cancer treatment for technology assessment and cancer treatment guidelines: American society of clinical oncology. J Clin Oncol 1996;14:671-679.
25. Yancik R, Edwards BK, Yates JW: Assessing the quality of life of cancer patients: practical issues in study implementation. J Psychosoc Oncol 1989;7: 59-74.
26. Wong J, Hird A, Kirou-Mauro A, Napolskikh J, Chow E: Quality of life in brain metastases radiation trials: a literature review. Curr Oncol 2008;15:25-45.
27. Buchanan DR, O'Mara AM, Kelaghan J W, Minasian LM: Quality-of-life assessment in the symptom management trials of the National Cancer Institute-supported community clinical oncology program. J Clin Oncol 2005;23:591-598.
28. Conill C, Verger E, Salamero M: Performance status assessment in cancer patients. Cancer 1990;65:1864-1866.
29. Grieco A, Long CJ: Investigation of the Karnofsky performance status as a measure of quality of life. Health Psychol 1984;3:129-142.
30. Ochs J, Mulhern R, Kun L: Quality-of-life assessment in cancer patients. Am J Clin Oncol 1988;11: 415-421.
31. Chow E, Davis L, Holden L, Tsao M, Danjoux C: Prospective assessment of patient-rated symptoms following whole brain radiotherapy for brain metastases. J Pain Symptom Manage 2005;30:18-23.
32. Gerrard GE, Prestwich RJ, Edwards A, Russon LJ, Richards F, Johnston CF, Kwok-Williams MC: Investigating the palliative efficacy of whole-brain radiotherapy for patients with multiple-brain metastases and poor prognostic features. Clin Oncol (R Coll Radiol) 2003;15:422-428.
33. Scott C, Suh J, Stea B, Nabid A, Hackman J: Improved survival, quality of life, and quality-adjusted survival in breast cancer patients treated with efaproxiral (Efaproxyn) plus whole-brain radiation therapy for brain metastases. Am J Clin Oncol 2007;30:580-587.
34. Sehlen S, Lenk M, Hollenhorst H, Schymura B, Aydemir U, Herschbach P, Duhmke E: Quality of life (QOL) as predictive mediator variable for survival in patients with intracerebral neoplasma during radiotherapy. Onkologie 2003;26:38-43.
35. Regine WF, Scott C, Murray K, Curran W: Neurocognitive outcome in brain metastases patients treated with accelerated-fractionation vs. accelerated-hyperfractionated radiotherapy: an analysis from radiation therapy oncology group study 91-04. Int J Radiat Oncol Biol Phys 2001; 51:711-717.
36. Kondziolka D, Niranjan A, Flickinger JC, Lunsford LD: Radiosurgery with or without whole-brain radiotherapy for brain metastases: the patients' perspective regarding complications. Am J Clin Oncol 2005;28:173-179.
37. Herman MA, Tremont-Lukats I, Meyers CA, Trask DD, Froseth C, Renschler MF, Mehta MP: Neurocognitive and functional assessment of patients with brain metastases: a pilot study. Am J Clin Oncol 2003;26:273-279.
38. Brown PD, Asher AL, Farace E: Adjuvant whole brain radiotherapy: strong emotions decide but rational studies are needed. Int J Radiat Oncol Biol Phys 2008;70:1305-1309.
39. Lo SS, Chang EL, Suh JH: Stereotactic radiosurgery with and without whole-brain radiotherapy for newly diagnosed brain metastases. Expert Rev Neurother 2005;5:487-495.
40. Patchell RA, Regine WF, Loeffler JS, Sawaya R, Andrews DW, Chin LS: Radiosurgery plus whole-brain radiation therapy for brain metastases. JAMA 2006;296:2089-2090.
41. Regine WF, Huhn JL, Patchell RA, St Clair WH, Strottmann J, Meigooni A, Sanders M, Young AB: Risk of symptomatic brain tumor recurrence and neurologic deficit after radiosurgery alone in patients with newly diagnosed brain metastases: results and implications. Int J Radiat Oncol Biol Phys 2002;52:333-338.
42. Andrews D W, Scott CB, Sperduto PW, Flanders AE, Gaspar LE, Schell MC, Werner-Wasik M, Demas W, Ryu J, Bahary J P, Souhami L, Rotman M, Mehta MP, Curran WJ Jr: Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial. Lancet 2004;363:1665-1672.
43. Fujii O, Tsujino K, Soejima T, Yoden E, Ichimiya Y, Sugimura K: White matter changes on magnetic resonance imaging following whole-brain radiotherapy for brain metastases. Radiat Med 2006; 24:345-350.
44. Chang EL, Wefel JS, Hess KR, Allen PK, Lang FF, Kornguth DG, Arbuckle RB, Swint JM, Shiu AS, Maor MH, Meyers CA: Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial. Lancet Oncol 2009;10: 1037-1044.
45. Aoyama H, Shirato H, Tago M, Nakagawa K, Toyoda T, Hatano K, Kenjyo M, Oya N, Hirota S, Shioura H, Kunieda E, Inomata T, Hayakawa K, Katoh N, Kobashi G: Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial. JAMA 2006;295:2483-2491.
46. Martins AN, Johnston JS, Henry JM, Stoffel TJ, Di Chiro G: Delayed radiation necrosis of the brain. J Neurosurg 1977;47:336-345.
47. Kjelberg RN: Isoeffective dose parameters for brain necrosis in relation to proton radiosurgical dosime-try; in Szilka G (ed): Stereotactic Cerebral Irradiation Inserm Symposium. Amsterdam, Elsevier Press, 1979, pp 157-166.
48. Williamson R, Kondziolka D, Kanaan H, Lunsford LD, Flickinger JC: Adverse radiation effects after radiosurgery may benefit from oral vitamin E and pentoxifylline therapy: a pilot study. Stereotact Funct Neurosurg 2008;86:359-366.
49. Shaw EG, Coffey RJ, Dinapoli RP: Neurotoxicity of radiosurgery. Semin Radiat Oncol 1995;5:235-245.
50. Shaw E, Scott C, Souhami L, Dinapoli R, Bahary JP, Kline R, Wharam M, Schultz C, Davey P, Loeffler J, Del Rowe J, Marks L, Fisher B, Shin K: Radiosurgery for the treatment of previously irradiated recurrent primary brain tumors and brain metastases: initial report of radiation therapy oncology group protocol (90-05). Int J Radiat Oncol Biol Phys 1996;34:647-654.
51. Shaw E, Scott C, Souhami L, Dinapoli R, Kline R, Loeffler J, Farnan N: Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90-05. Int J Radiat Oncol Biol Phys 2000;47:291-298.
52. Shehata MK, Young B, Reid B, Patchell RA, St Clair W, Sims J, Sanders M, Meigooni A, Mohiuddin M, Regine WF: Stereotatic radiosurgery of 468 brain metastases < or =2 cm: implications for SRS dose and whole brain radiation therapy. Int J Radiat Oncol Biol Phys 2004;59:87-93.
53. Chin LS, Levy ML, Rabb CH, Chandrasoma PT, Zee CS, Apuzzo MJ: Principles and pitfalls of image directed stereotactic biopsy of brain lesions; in Thomas DGT (ed): Stereotactic and Image Directed Surgery of Brain Tumours. Edinburgh, Churchill Livingstone, 1993, pp 49-63.
54. Lunsford LD: Diagnosis and treatment of mass lesions using the leksell stereotactic system; in Lunsford LD (ed): Modern Stereotactic Neurosurgery. Boston, Nijhoff, 1988, pp 45-168.
55. Chao ST, Suh JH, Raja S, Lee SY, Barnett G: The sensitivity and specificity of fdg pet in distinguishing recurrent brain tumor from radionecrosis in patients treated with stereotactic radiosurgery. Int J Cancer 2001;96:191-197.
56. Tsuyuguchi N, Sunada I, Iwai Y, Yamanaka K, Tanaka K, Takami T, Otsuka Y, Sakamoto S, Ohata K, Goto T, Hara M: Methionine positron emission tomography of recurrent metastatic brain tumor and radiation necrosis after stereotactic radiosur-gery: is a differential diagnosis possible? J Neurosurg 2003;98:1056-1064.
57. Dequesada IM, Quisling RG, Yachnis A, Friedman WA: Can standard magnetic resonance imaging reliably distinguish recurrent tumor from radiation necrosis after radiosurgery for brain metastases? A radiographic-pathological study. Neurosurgery 2008;63:898-903.
58. Kano H, Kondziolka D, Lobato-Polo J, Zorro O, Flickinger JC, Lunsford LD: T1/t2 matching to differentiate tumor growth from radiation effects after stereotactic radiosurgery. Neurosurgery 2010;66: 486-491.
59. Deutsch M, Parsons JA, Mercado R Jr: Radiotherapy for intracranial metastases. Cancer 1974;34:1607-1611.
60. Theodore WH, Gendelman S: Meningeal carcino-matosis. Arch Neurol 1981;38:696-699.
61. Horton J, Baxter DH, Olson KB: The management of metastases to the brain by irradiation and corti-costeroids. Am J Roentgenol Radium Ther Nucl Med 1971;111:334-336.
62. Markesbery WR, Brooks WH, Gupta GD, Young AB: Treatment for patients with cerebral metastases. Arch Neurol 1978;35:754-756.
63. Leksell L: Stereotactic radiosurgery. J Neurol Neurosurg Psychiatry 1983;46:797-803.
64. Lindquist C: Gamma knife surgery for recurrent solitary metastasis of a cerebral hypernephroma: case report. Neurosurgery 1989;25:802-804.
65. Linskey ME, Andrews D W, Asher AL, et al: The role of stereotactic radiosurgery in the management of patients with newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncol 2010;96:45-68.
66. Kondziolka D, Patel A, Lunsford LD, Kassam A, Flickinger JC: Stereotactic radiosurgery plus whole brain radiotherapy versus radiotherapy alone for patients with multiple brain metastases. Int J Radiat Oncol Biol Phys 1999;45:427-434.
67. Varlotto JM, Flickinger JC, Niranjan A, Bhatnagar A, Kondziolka D, Lunsford LD: The impact of whole-brain radiation therapy on the long-term control and morbidity of patients surviving more than one year after Gamma Knife radiosurgery for brain metastases. Int J Radiat Oncol Biol Phys 2005;62:1125-1132.
68. Li B, Yu J, Suntharalingam M, Kennedy AS, Amin PP, Chen Z, Yin R, Guo S, Han T, Wang Y, Yu N, Song G, Wang L: Comparison of three treatment options for single brain metastasis from lung cancer. Int J Cancer 2000;90:37-45.
69. Wang LG, Guo Y, Zhang X, Song SJ, Xia JL, Fan FY, Shi M, Wei LC: Brain metastasis: experience of the Xi-Jing Hospital. Stereotact Funct Neurosurg 2002; 78:70-83.
70. Combs SE, Schulz-Ertner D, Thilmann C, Edler L, Debus J: Treatment of cerebral metastases from breast cancer with stereotactic radiosurgery. Strahlenther Onkol 2004;180:590-596.
71. Hoffman R, Sneed PK, McDermott M W, Chang S, Lamborn KR, Park E, Wara WM, Larson DA: Radiosurgery for brain metastases from primary lung carcinoma. Cancer J 2001;7:121-131.
72. Jawahar A, Willis BK, Smith DR, Ampil F, Datta R, Nanda A: Gamma Knife radiosurgery for brain metastases: do patients benefit from adjuvant external-beam radiotherapy? An 18-month comparative analysis. Stereotact Funct Neurosurg 2002;79:262-271.
73. Pirzkall A, Debus J, Lohr F, Fuss M, Rhein B, Engenhart-Cabillic R, Wannenmacher M: Radiosurgery alone or in combination with whole-brain radiotherapy for brain metastases. J Clin Oncol 1998;16:3563-3569.
74. Sneed PK, Suh JH, Goetsch SJ, Sanghavi SN, Chappell R, Buatti JM, Regine WF, Weltman E, King VJ, Breneman JC, Sperduto P W, Mehta MP: A multi-institutional review of radiosurgery alone vs. radiosurgery with whole brain radiotherapy as the initial management of brain metastases. Int J Radiat Oncol Biol Phys 2002;53:519-526.
75. Rades D, Pluemer A, Veninga T, Hanssens P, Dunst J, Schild SE: Whole-brain radiotherapy versus ste-reotactic radiosurgery for patients in recursive partitioning analysis classes 1 and 2 with 1 to 3 brain metastases. Cancer 2007;110:2285-2292.
76. Kocher M, Maarouf M, Bendel M, Voges J, Muller R P, Sturm V: Linac radiosurgery versus whole brain radiotherapy for brain metastases: a survival comparison based on the RTOG recursive partitioning analysis. Strahlenther Onkol 2004;180:263-267.
77. Muacevic A, Wowra B, Siefert A, Tonn JC, Steiger HJ, Kreth FW: Microsurgery plus whole brain irradiation versus Gamma Knife surgery alone for treatment of single metastases to the brain: a randomized controlled multicentre phase III trial. J Neurooncol 2008;87:299-307.
78. Muacevic A, Kreth F W, Horstmann GA, Schmid-Elsaesser R, Wowra B, Steiger HJ, Reulen HJ: Surgery and radiotherapy compared with Gamma Knife radiosurgery in the treatment of solitary cerebral metastases of small diameter. J Neurosurg 1999;91:35-43.
79. Rades D, Bohlen G, Pluemer A, Veninga T, Hanssens P, Dunst J, Schild SE: Stereotactic radiosurgery alone versus resection plus whole-brain radiotherapy for 1 or 2 brain metastases in recursive partitioning analysis class 1 and 2 patients. Cancer 2007;109: 2515-2521.
80. Shinoura N, Yamada R, Okamoto K, Nakamura O, Shitara N: Local recurrence of metastatic brain tumor after stereotactic radiosurgery or surgery plus radiation. J Neurooncol 2002;60:71-77.
81. Halliday D, Resnick R, Walker J: Fundamentals of Physics, ed 7. New York, Wiley, 2004.
82. Sisterson J: Particle therapy co-operative group (PTCOG). Particles Newslett 2005;35.
83. Chen CC, Chapman P, Petit J, Loeffler J: Proton radiosurgery in neurosurgery. Neurosurg Focus 2007;23:E5.
84. Bova FJ: Radiation physics. Neurosurg Clin N Am 1990;1:909-931.
85. Serizawa T: Radiosurgery for metastatic brain tumors. Int J Clin Oncol 2009;14:289-298.
86. Ulm AJ, Friedman WA, Bova FJ, Bradshaw P, Amdur RJ, Mendenhall WM: Linear accelerator radiosur-gery in the treatment of brain metastases. Neurosurgery 2004;55:1076-1085.
87. Rahman M, Murad GJ, Bova F, Friedman WA, Mocco J: Stereotactic radiosurgery and the linear accelerator: accelerating electrons in neurosurgery. Neurosurg Focus 2009;27:E13.
88. Lunsford LD, Flickinger J, Lindner G, Maitz A: Stereotactic radiosurgery of the brain using the first United States 201 cobalt-60 source Gamma Knife. Neurosurgery 1989;24:151-159.
89. Sanoff HK, Sargent DJ, Campbell ME, Morton RF, Fuchs CS, Ramanathan RK, Williamson SK, Findlay B P, Pitot HC, Goldberg RM: Five-year data and prognostic factor analysis of oxaliplatin and irinote-can combinations for advanced colorectal cancer: N9741. J Clin Oncol 2008;26:5721-5727.
90. Kondziolka D, Martin JJ, Flickinger JC, Friedland DM, Brufsky AM, Baar J, Agarwala S, Kirkwood JM, Lunsford LD: Long-term survivors after Gamma Knife radiosurgery for brain metastases. Cancer 2005;104:2784-2791.
91. Chu FC, Hilaris BB: Value of radiation therapy in the management of intracranial metastases. Cancer 1961;14:577-581.
92. Chao JH, Phillips R, Nickson JJ: Roentgen-ray therapy of cerebral metastases. Cancer 1954;7:682-689.
93. Sneed PK, Lamborn KR, Forstner JM, McDermott M W, Chang S, Park E, Gutin PH, Phillips TL, Wara WM, Larson DA: Radiosurgery for brain metastases: Is whole brain radiotherapy necessary? Int J Radiat Oncol Biol Phys 1999;43:549-558.
94. Hazuka MB, Kinzie JJ: Brain metastases: results and effects of re-irradiation. Int J Radiat Oncol Biol Phys 1988;15:433-437.
95. Wong W W, Schild SE, Sawyer TE, Shaw EG: Analysis of outcome in patients reirradiated for brain metastases. Int J Radiat Oncol Biol Phys 1996;34:585-590.
96. Chao ST, Barnett GH, Vogelbaum MA, Angelov L, Weil RJ, Neyman G, Reuther AM, Suh JH: Salvage stereotactic radiosurgery effectively treats recurrences from whole-brain radiation therapy. Cancer 2008;113:2198-2204.
97. Noel G, Proudhom MA, Valery CA, et al: Radiosurgery for re-irradiation of brain metastasis: results in 54 patients. Radiother Oncol 2001;60:61-67.
98. Mathieu D, Kondziolka D, Flickinger JC, Fortin D, Kenny B, Michaud K, Mongia S, Niranjan A, Lunsford LD: Tumor bed radiosurgery after resection of cerebral metastases. Neurosurgery 2008;62: 817-823.
99. Soltys SG, Adler JR, Lipani JD, Jackson PS, Choi CY, Puataweepong P, White S, Gibbs IC, Chang SD: Stereotactic radiosurgery of the postoperative resection cavity for brain metastases. Int J Radiat Oncol Biol Phys 2008;70:187-193.
100. Karlovits BJ, Quigley MR, Karlovits SM, Miller L, Johnson M, Gayou O, Fuhrer R: Stereotactic radio-surgery boost to the resection bed for oligometa-static brain disease: challenging the tradition of adjuvant whole-brain radiotherapy. Neurosurg Focus 2009;27:E7.
101. Jagannathan J, Yen C P, Ray DK, Schlesinger D, Oskouian RJ, Pouratian N, Shaffrey ME, Larner J, Sheehan JP: Gamma knife radiosurgery to the surgical cavity following resection of brain metastases. J Neurosurg 2009;111:431-438.
102. DeAngelis LM, Mandell LR, Thaler HT, Kimmel D W, Galicich JH, Fuks Z, Posner JB: The role of postoperative radiotherapy after resection of single brain metastases. Neurosurgery 1989;24:798-805.
103. Quigley MR, Fuhrer R, Karlovits S, Karlovits B, Johnson M: Single session stereotactic radiosurgery boost to the post-operative site in lieu of whole brain radiation in metastatic brain disease. J Neurooncol 2008;87:327-332.
104. Noordijk EM, Vecht CJ, Haaxma-Reiche H, et al.: The choice of treatment of single brain metastasis should be based on extracranial tumor activity and age. Int J Radiat Oncol Biol Phys 1994;29:711-717.
105. Bindal AK, Bindal RK, Hess KR, Shiu A, Hassenbusch SJ, Shi WM, Sawaya R: Surgery versus radiosurgery in the treatment of brain metastasis. J Neurosurg 1996;84:748-754.
106. Bindal RK, Sawaya R, Leavens ME, Lee JJ: Surgical treatment of multiple brain metastases. J Neurosurg 1993;79:210-216.
107. Hwang S W, Abozed MM, Hale A, Eisenberg RL, Dvorak T, Yao K, Pfannl R, Mignano J, Zhu JJ, Price LL, Strauss GM, Wu JK: Adjuvant gamma knife radiosurgery following surgical resection of brain metastases: a 9-year retrospective cohort study. J Neurooncol 2010;98:77-82.